4-bromo-2-[(6,7-dimethoxy-3,4-dihydroisoquinolin-2(1H)-yl)methyl]phenol | 1022010-93-0

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 异喹啉及其衍生物
• 英文名称: 4-bromo-2-[(6,7-dimethoxy-3,4-dihydroisoquinolin-2(1H)-yl)methyl]phenol
• 英文别名: 4-bromo-2-[(6,7-dimethoxy-3,4-dihydro-1H-isoquinolin-2-yl)methyl]phenol
• CAS: 1022010-93-0
• 化学式: C₁₈H₂₀BrNO₃
• 分子量: 378.266
• InChiKey: OXFXWAARWGCHIQ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.6
• 重原子数：
  23
• 可旋转键数：
  4
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  41.9
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  6,7-二甲氧基-3,4-二氢异喹啉 、 5-溴-2-羟基苯甲醇 以 邻二甲苯 为溶剂， 以49%的产率得到4-bromo-2-[(6,7-dimethoxy-3,4-dihydroisoquinolin-2(1H)-yl)methyl]phenol
  参考文献：
  名称：

  Reactions of 6,7-dimethoxy- 3,4-dihydroisoquinoline with o-quinone methides

  摘要：

  Products of heterocyclization, 9,10-dimethoxy-12,13-dihydro-7aH,15H-naphtho[1',2':5,6][1,3]oxazino[2,3-a]isoquinolines, were isolated on condensing 6,7-dimethoxy-3,4-dihydroisoquinoline with 1-dimethylaminomethyl-2-naphthols. In the case of o-hydroxybenzyl alcohols products of a Michael aza reaction, 2-[(6,7-dimethoxy-3,4-dihydroisoquinolin-2(1H)-yl)methyl]phenols were obtained.

  DOI：

  10.1007/s10593-011-0845-6

文献信息

• Reactions of 6,7-dimethoxy- 3,4-dihydroisoquinoline with o-quinone methides
  作者：V. A. Osyanin、E. A. Ivleva、D. V. Osipov、Yu. N. Klimochkin

  DOI：10.1007/s10593-011-0845-6

  日期：2011.10

  Products of heterocyclization, 9,10-dimethoxy-12,13-dihydro-7aH,15H-naphtho[1',2':5,6][1,3]oxazino[2,3-a]isoquinolines, were isolated on condensing 6,7-dimethoxy-3,4-dihydroisoquinoline with 1-dimethylaminomethyl-2-naphthols. In the case of o-hydroxybenzyl alcohols products of a Michael aza reaction, 2-[(6,7-dimethoxy-3,4-dihydroisoquinolin-2(1H)-yl)methyl]phenols were obtained.