2,2-Diisopropyl-<1,3>-dithian | 5849-29-6

• 分子结构分类: 有机化合物 - 有机硫化合物 - 硫代缩醛
• 英文名称: 2,2-Diisopropyl-<1,3>-dithian
• 英文别名: 2,2-Diisopropyl-1,3-dithian；2,2-Di(propan-2-yl)-1,3-dithiane
• CAS: 5849-29-6
• 化学式: C₁₀H₂₀S₂
• 分子量: 204.401
• InChiKey: NETBVCGISAFKON-UHFFFAOYSA-N

物化性质

• 沸点：
  268.3±23.0 °C(predicted)
• 密度：
  0.982±0.06 g/cm3(Temp: 20 °C; Press: 760 Torr)(predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  4.3
• 重原子数：
  12
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  50.6
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  1,3-丙二硫醇 、 2,4-二甲基-3-戊酮 在 Preyssler-type heteropolyacid 作用下， 以 氯仿 为溶剂， 反应 0.75h， 以87%的产率得到2,2-Diisopropyl-<1,3>-dithian
  参考文献：
  名称：

  Preyssler-type heteropoly acid: A new, mild and efficient catalyst for protection of carbonyl compounds

  摘要：

  Preyssler-type heteropoly acid is introduced as a new, mild and efficient catalyst for protection of a variety of carbonyl compounds with 1,3-propane dithiol. (C) 2010 Mohammad Rahimizadeh. Published by Elsevier B.V. on behalf of Chinese Chemical Society. All rights reserved.

  DOI：

  10.1016/j.cclet.2010.10.052

文献信息

• AMINOTHIAZINE OR AMINOOXAZINE DERIVATIVE HAVING AMINO LINKER
  申请人：Masui Moriyasu

  公开号：US20120238557A1

  公开（公告）日：2012-09-20

  The present invention provide a medicament for treating the diseases induced by production, secretion or deposition of amyloid-β proteins, for example, a compound of the following formula (I) wherein R 1 , R 2a , R 2b , R 3 , R 4 , R 5 , X, L 1 , L 2 , A, ring B and the dotted line are defined in the specification, its pharmaceutically acceptable salt or a solvate thereof.

  本发明提供了一种治疗由淀粉样蛋白β的产生、分泌或沉积引起的疾病的药物，例如以下式(I)的化合物，其中R1、R2a、R2b、R3、R4、R5、X、L1、L2、A、环B和虚线在规范中有定义，其药学上可接受的盐或溶剂化合物。
• FUSED HETEROCYCLIC COMPOUND HAVING AMINO GROUP
  申请人：Yoshida Syuhei

  公开号：US20120245155A1

  公开（公告）日：2012-09-27

  The present invention provides, for example, a compound mentioned below as a medicament for treating or preventing the diseases induced by production, secretion or deposition of amyloid-βproteins. A compound of the formula (I): wherein R 1 , R 2a , R 2b , R 3 , R 4 , R 5a , R 5b , R 6a , R 6b , X, Y, Z, ring A and the dashed lines are defined in the specification, its pharmaceutically acceptable salt or a solvate thereof.

  本发明提供了一个如下所述的化合物作为治疗或预防由淀粉样β蛋白的产生、分泌或沉积引起的疾病的药物。式（I）的化合物：其中R1、R2a、R2b、R3、R4、R5a、R5b、R6a、R6b、X、Y、Z、环A和虚线在说明书中定义，其药用可接受的盐或其溶剂化合物。
• FUSED AMINODIHYDROPYRIMIDINE DERIVATIVE
  申请人：Masui Moriyasu

  公开号：US20130210839A1

  公开（公告）日：2013-08-15

  The present invention provides, for example, the following compound: wherein ring A is a substituted or unsubstituted carbocycle or a substituted or unsubstituted heterocycle, X 1 —X 2 ═X 3 is CR 5 —CR 6 ═CR 7 , N—CR 6 ═CR 7 , CR 5 —N═CR 7 or CR 5 —CR 6 ═N, R 1 is substituted or unsubstituted alkyl, substituted or unsubstituted alkenyl or the like, R 2a and R 2b are each independently hydrogen, substituted or unsubstituted alkyl or the like, R 4a , R 4b , R 5 , R 6 and R 7 are each independently hydrogen, halogen, hydroxy, substituted or unsubstituted alkyl or the like, its pharmaceutically acceptable salt or a solvate thereof having an effect of inhibiting amyloid β production, especially a BACE1 inhibitory activity, and useful as a medicament for treating diseases induced by production, secretion or deposition of amyloid β proteins.

  本发明提供了如下化合物：其中环A是取代或未取代的碳环或取代或未取代的杂环，X1—X2═X3为CR5—CR6═CR7，N—CR6═CR7，CR5—N═CR7或CR5—CR6═N，R1为取代或未取代的烷基，取代或未取代的烯基等，R2a和R2b各自独立为氢，取代或未取代的烷基等，R4a，R4b，R5，R6和R7各自独立为氢，卤素，羟基，取代或未取代的烷基等，其药学上可接受的盐或其溶剂化合物具有抑制淀粉样蛋白β产生的作用，特别是BACE1抑制活性，并可用作治疗由淀粉样蛋白β蛋白产生、分泌或沉积引起的疾病的药物。
• NAPHTHYRIDINE DERIVATIVE
  申请人：Mitsuoka Yasunori

  公开号：US20130217705A1

  公开（公告）日：2013-08-22

  The present invention provides, for example, the following compound: wherein ring Z is pyridine or a carbocycle, each of which is substituted or unsubstituted, ring A is a carbocycle or a heterocycle, each of which is substituted or unsubstituted, R 1 is substituted or unsubstituted alkyl or the like, R 2a , R 2b , R 4a and R 4b are each independently hydrogen or substituted or unsubstituted alkyl or the like, its pharmaceutically acceptable salt or a solvate thereof having an effect of inhibiting amyloid β production, especially a BACE1 inhibitory activity, and useful as a medicament for treating diseases induced by production, secretion or deposition of amyloid β proteins.

  本发明提供了以下化合物：其中环Z是吡啶或碳环，每个都是取代或未取代的，环A是碳环或杂环，每个都是取代或未取代的，R1是取代或未取代的烷基或类似物，R2a、R2b、R4a和R4b分别独立地是氢或取代或未取代的烷基或类似物，其药学上可接受的盐或其溶剂化合物具有抑制淀粉样蛋白β产生的作用，特别是BACE1抑制活性，并且作为治疗由淀粉样蛋白β蛋白的产生、分泌或沉积引起的疾病的药物而有用。
• 4-AMINO-1,3-THIAZINE OR OXAZINE DERIVATIVE
  申请人：Suzuki Shinji

  公开号：US20120258961A1

  公开（公告）日：2012-10-11

  The present invention provide a medicament for treating the diseases induced by production, secretion or deposition of amyloid-β proteins, for example, a compound of the following formula (I) wherein R 1 , R 2a , R 2b , R 3a , R 3b , R 4a , R 4b , ring A, Y and the dotted line are defined in the specification, its pharmaceutically acceptable salt or a solvate thereof.

  本发明提供了一种用于治疗由淀粉样蛋白β的产生、分泌或沉积引起的疾病的药物，例如，以下式(I)的化合物，其中R1、R2a、R2b、R3a、R3b、R4a、R4b、环A、Y和点线在规范中定义，其药学上可接受的盐或溶剂化物。