2,2-diisopropyl-[1,3]dithiolane | 6008-77-1

• 分子结构分类: 有机化合物 - 有机硫化合物 - 硫代缩醛
• 英文名称: 2,2-diisopropyl-[1,3]dithiolane
• 英文别名: 2,2-Diisopropyl-[1,3]dithiolan；2,2-Di(propan-2-yl)-1,3-dithiolane
• CAS: 6008-77-1
• 化学式: C₉H₁₈S₂
• 分子量: 190.374
• InChiKey: UFWUOAQZTXJGQU-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.9
• 重原子数：
  11
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  50.6
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  dimethylsulfide dibromide 、 2,2-diisopropyl-[1,3]dithiolane 、 水 以70%的产率得到
  参考文献：
  名称：

  OLAH G. A.; VANKAR Y. D.; ARVANAGHI M.; SURVA PRAKASH G. K., SYNTHESIS, 1979, NO 9, 720-721

  摘要：

  DOI：
• 作为产物：
  描述：

  1,2-乙二硫醇 、 2,4-二甲基-3-戊酮 在 盐酸 作用下， 生成 2,2-diisopropyl-[1,3]dithiolane
  参考文献：
  名称：

  SOME MERCAPTOLES OF 1,2-ETHANEDITHIOL¹

  摘要：

  DOI：

  10.1021/jo01148a034

文献信息

• Ketones and reduced ketones as therapeutic agents for the treatment of bone conditions
  申请人：Ralston Hamilton Stuart

  公开号：US20070027112A1

  公开（公告）日：2007-02-01

  The present invention pertains to certain ketones and reduced ketones and derivatives thereof which, inter alia, inhibit osteoclast survival, formation, and/or activity; and/or inhibit bone resorption, and more particularly to compounds of the formulae: (1) (2) wherein: Ar 1 is independently a biphenyl, phenanthryl, fluorenyl, or carbazolyl, and is optionally substituted; R alk is independently a C 2-10 alkylene group, and is optionally substituted; —OR O , if present, is independently —OH or —OR K ; —OR K , if present, is independently selected from: —O—R K1 ; —O—C(═O)R K2 ; —O—C(═O)OR K3 ; —O—S(═O)2OR K4 ; Q is independently —OH or —OR OT ; wherein: —OR OT , if present, is independently selected from: —O—R E1 ; —O—C(═O)—R E2 ; —O—C(═O)—O—R E3 ; —O—C(═O)—O—SO 3 R E4 ; —O—C(═O)—O—(CH 2 ) n —COOR E5 ; —O—C(═O)—(CH 2 ) n —NR N1 R N2 ; —O—C(═O)—(CH 2 ) n —NH—C(═O)R E6 ; —O—C(═O)—(CH 2 ) n —C(═O)—NR N3 R N4 ; —O—P(═O)(OR E7 )(OR E8 ); —O—R PA ; R PA , if present, is an organic group which incorporates a phosphonic acid group; with the proviso A that if —OR OT is —O—R E1 , then R E1 is not a phenyl group substituted with a sulfonyl group; and pharmaceutically acceptable salts, solvates, amides, esters, ethers, chemically protected forms, or prodrugs thereof. The present invention also pertains to pharmaceutical compositions comprising such compounds, and the use of such compounds and compositions, both in vitro and in vivo, to inhibit osteoclast survival, formation, and/or activity, and to inhibit conditions mediated by osteoclasts and/or characterised by bone resorption, in the treatment of bone disorders such as osteoporosis, rheumatoid arthritis, cancer associated bone disease, Paget's disease, aseptic loosening of prosthetic implants, and the like; and/or in the treatment of conditions associated with inflammation or activation of the immune system.

  本发明涉及某些酮和还原酮及其衍生物，其中包括抑制破骨细胞的存活、形成和/或活性；和/或抑制骨吸收的化合物，更具体地说，是以下式子的化合物：（1）（2） 其中：Ar1独立地是联苯基，菲基，芴基或咔唑基，且可以被取代；Ralk独立地是C2-10烷基，且可以被取代；-ORO，如果存在，则独立地是-OH或-ORK；-ORK，如果存在，则独立地选自：-O-RK1；-O-C（═O）-RK2；-O-C（═O）-ORK3；-O-S（═O）2ORK4；Q独立地是-OH或-OROT；其中：-OROT，如果存在，则独立地选自：-O-RE1；-O-C（═O）-RE2；-O-C（═O）-O-RE3；-O-C（═O）-O-SO3RE4；-O-C（═O）-O-（CH2）n-COORE5；-O-C（═O）-（ ）n-NRN1RN2；-O-C（═O）-（ ）n-NH-C（═O）RE6；-O-C（═O）-（ ）n-C（═O）-NRN3RN4；-O-P（═O）（ORE7）（ORE8）；-O-RPA；如果存在RPA，则是包含膦酸基的有机基团；但前提是如果-OROT是-O-RE1，则RE1不是取代有磺酰基的苯基；以及其药学上可接受的盐、溶剂化合物、酰胺、酯、醚、化学保护形式或前药。本发明还涉及包含这种化合物的制药组合物，以及这种化合物和组合物的使用，无论是在体内还是体外，以抑制破骨细胞的存活、形成和/或活性，并抑制由破骨细胞介导和/或特征为骨吸收的疾病，如骨质疏松症、类风湿性关节炎、癌症相关骨病、帕吉特病、假体松动等；和/或用于治疗与炎症或免疫系统激活相关的疾病。
• KETONES AND REDUCED KETONES AS THERAPEUTIC AGENTS FOR THE TREATMENT OF BONE CONDITIONS
  申请人：RALSTON Stuart H.

  公开号：US20080312186A1

  公开（公告）日：2008-12-18

  The present invention pertains to certain ketones and reduced ketones and derivatives thereof which, inter alia, inhibit osteoclast survival, formation, and/or activity; and/or inhibit bone resorption, and more particularly to compounds of the formulae and pharmaceutically acceptable salts, amides, esters, and ethers thereof, wherein: Ar1, R alk , —ORO, and -Q are as defined herein: The present invention also pertains to pharmaceutical compositions comprising such compounds. The compounds inhibit osteoclast survival, formation, and/or activity, and inhibit conditions mediated by osteoclasts and/or characterised by bone resorption, and are useful in the treatment of bone disorders such as osteoporosis, rheumatoid arthritis, cancer associated bone disease, Paget's disease, aseptic loosening of prosthetic implants, and the like; and/or in the treatment of conditions associated with inflammation or activation of the immune system.

  本发明涉及某些酮和还原酮及其衍生物，其中包括抑制破骨细胞的存活、形成和/或活性；和/或抑制骨吸收的化合物，更具体地，涉及以下式子的化合物和其药学上可接受的盐，酰胺，酯和醚，其中：Ar1，Ralk，—ORO和-Q如本文所定义的：本发明还涉及包含这些化合物的药物组合物。这些化合物抑制破骨细胞的存活、形成和/或活性，并抑制由破骨细胞介导和/或以骨吸收为特征的疾病，并可用于治疗骨疾病，如骨质疏松症、类风湿性关节炎、与癌症相关的骨疾病、帕吉特病、人工假体无菌松动等；和/或用于治疗与炎症或免疫系统激活相关的疾病。
• Pharmaceutical composition for prophylaxis or treatment of ketosis in livestock
  申请人：NIHON NOHYAKU CO., LTD.

  公开号：EP0134112A2

  公开（公告）日：1985-03-13

  A pharmaceutical composition for prophylaxis or treatment of ketosis in livestock which contains a dithia derivative represented by the general formula (I), wherein R and R' may be the same or different and are each indivisually a lower alkyl group, n is an integer of 0, 1 or 2; and A is a group of the formula, -CHz-, (where M is a hydrogen atom or a salt-forming residue), -CH=CH-, -CH2CH2-,

  一种用于预防或治疗家畜酮病的药物组合物，其中含有通式（I）所代表的二硫杂环己烷衍生物，其中 R 和 R'可以相同或不同，且各自独立地为低级烷基，n 为 0、1 或 2 的整数；A 为式中的基团，-CHz-，（其中 M 为氢原子或成盐残基），-CH=CH-，-CH2CH2-、
• TRIAZOLE COMPOUND AND INSECTICIDE
  申请人：S.D.S. BIOTECH K.K.

  公开号：EP0471092A1

  公开（公告）日：1992-02-19

  A triazole compound of general formula (I) and an insecticide containing the same as the active ingredient, wherein R₁ represents hydrogen or lower alkyl; R₂ represents lower alkyl; R₃ represents alkyl, alkenyl, cycloalkylmethyl or haloalkyl, alkyl, alkenyl, hydroxyalkyl, thioxyalkyl or carbonylalkyl each substituted with an optionally substituted phenyl, alkyl substituted with alkoxy or alkylthio, alkyl substituted with alkylsulfinyl or alkylsulfonyl, alkyl substituted with α-, β- or γ-pyridyl, alkyl substituted with α- or β-thienyl optionally substituted with halogen, alkyl substituted with cyano, or alkyl substituted with alkoxycarbonyl; and R₄ represents (a) wherein R₅, R₆ and R₇ represent the same or different alkyl or otherwise two of the R₅, R₆ and R₇ may form a carbocyclic ring.

  一种通式(I)的三唑化合物和一种含有通式(I)的三唑化合物作为活性成分的杀虫剂，其中R₁代表氢或低级烷基；R₂代表低级烷基；R₃代表烷基、烯基、环烷基甲基或卤代烷基、烷基、烯基、羟基烷基、硫代烷基或羰基烷基，每个烷基都被任选取代的苯基、被烷氧基或硫代烷基取代的烷基、被烷基亚磺酰基或烷基磺酰基取代的烷基、被α-、β-或γ-吡啶基取代的烷基、被α-或β-噻吩基任选取代的烷基、被氰基取代的烷基或被烷氧羰基取代的烷基；其中 R₅、R₆ 和 R₇ 代表相同或不同的烷基，或者 R₅、R₆ 和 R₇ 中的两个可以形成一个碳环。
• JPS5435218A
  申请人：——

  公开号：JPS5435218A

  公开（公告）日：1979-03-15