2-(7-氮杂双环[2.2.1]庚-7-基)乙醇 | 743438-25-7

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡咯烷类
• 中文名称: 2-(7-氮杂双环[2.2.1]庚-7-基)乙醇
• 英文名称: 2-(7-Azabicyclo[2.2.1]heptan-7-yl)ethan-1-ol
• 英文别名: 2-(7-azabicyclo[2.2.1]heptan-7-yl)ethanol
• CAS: 743438-25-7
• 化学式: C₈H₁₅NO
• 分子量: 141.213
• InChiKey: DKDSJBVYVDOPKH-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.7
• 重原子数：
  10
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  23.5
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  N-(2-morpholin-4-ylethyl)-2,4-dinitrobenzenesulfonamide 、 2-(7-氮杂双环[2.2.1]庚-7-基)乙醇 在 triphenylphosphine polystyrene 、 偶氮二甲酸二叔丁酯 作用下， 以 乙酸乙酯 为溶剂， 生成
  参考文献：
  名称：

  Synthesis and pharmacological evaluation of 1,1,3-substituted urea derivatives as potent TNF-α production inhibitors

  摘要：

  A three substituted urea derivative, SA13353 (compound 1a), exhibited potent inhibitory activity against lipopolysaccharide (LPS)-induced TNF-alpha production. We focused on the 1,1-substituted moiety (R(1) and R(2)) of SA13353 and investigated substituent effects of this moiety on LPS-induced TNF-alpha production by oral administration in rats. The synthesis of the urea derivatives was performed rapidly in a one-pot manner using a manual synthesizer. Several compounds containing hydrophobic substituents at this moiety showed more potent inhibitory activities than SA13353. (C) 2010 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2010.06.037
• 作为产物：
  描述：

  7-氮杂双环[2.2.1]庚烷 在 lithium aluminium tetrahydride 、 三乙胺 作用下， 以 乙醚 、 二氯甲烷 为溶剂， 生成 2-(7-氮杂双环[2.2.1]庚-7-基)乙醇
  参考文献：
  名称：

  Estrogen receptor ligands. Part 7: Dihydrobenzoxathiin SERAMs with bicyclic amine side chains

  摘要：

  A series of benzoxathiin SERAMs with bicyclic amine side chains was prepared. Minor modifications in the side chain resulted in significant effects or, biological activity, especially in uterine tissue. (C) 2004 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2004.05.074

文献信息

• WO2007/120600
  申请人：——

  公开号：——

  公开（公告）日：——
• Synthesis and pharmacological evaluation of 1,1,3-substituted urea derivatives as potent TNF-α production inhibitors
  作者：Hiroshi Enomoto、Ayako Sawa、Hiroshi Suhara、Noriyoshi Yamamoto、Hiroyuki Inoue、Chikako Setoguchi、Fumio Tsuji、Masahiro Okamoto、Yoshimasa Sasabuchi、Masato Horiuchi、Masakazu Ban

  DOI：10.1016/j.bmcl.2010.06.037

  日期：2010.8

  A three substituted urea derivative, SA13353 (compound 1a), exhibited potent inhibitory activity against lipopolysaccharide (LPS)-induced TNF-alpha production. We focused on the 1,1-substituted moiety (R(1) and R(2)) of SA13353 and investigated substituent effects of this moiety on LPS-induced TNF-alpha production by oral administration in rats. The synthesis of the urea derivatives was performed rapidly in a one-pot manner using a manual synthesizer. Several compounds containing hydrophobic substituents at this moiety showed more potent inhibitory activities than SA13353. (C) 2010 Elsevier Ltd. All rights reserved.
• Estrogen receptor ligands. Part 7: Dihydrobenzoxathiin SERAMs with bicyclic amine side chains
  作者：Timothy A Blizzard、Frank DiNinno、Jerry D Morgan、Helen Y Chen、Jane Y Wu、Candido Gude、Seongkon Kim、Wanda Chan、Elizabeth T Birzin、Yi Tien Yang、Lee-Yuh Pai、Zhoupeng Zhang、Edward C Hayes、Carolyn A DaSilva、Wei Tang、Susan P Rohrer、James M Schaeffer、Milton L Hammond

  DOI：10.1016/j.bmcl.2004.05.074

  日期：2004.8

  A series of benzoxathiin SERAMs with bicyclic amine side chains was prepared. Minor modifications in the side chain resulted in significant effects or, biological activity, especially in uterine tissue. (C) 2004 Elsevier Ltd. All rights reserved.