1-(4-methoxyphenylamino)-1-(naphthalen-1-yl)propan-2-one | 1012886-49-5

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 英文名称: 1-(4-methoxyphenylamino)-1-(naphthalen-1-yl)propan-2-one
• 英文别名: 1-(4-Methoxyanilino)-1-naphthalen-1-ylpropan-2-one；1-(4-methoxyanilino)-1-naphthalen-1-ylpropan-2-one
• CAS: 1012886-49-5
• 化学式: C₂₀H₁₉NO₂
• 分子量: 305.376
• InChiKey: POSVNLDSKOZYOG-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.6
• 重原子数：
  23
• 可旋转键数：
  5
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.15
• 拓扑面积：
  38.3
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  1-乙酰基咪唑 、 N-(1-naphthalenemethylene)-4-methoxybenzenamine 在 三甲基氯硅烷 、 tert-butylammonium hexafluorophosphate(V) 、 三乙胺 作用下， 以 四氢呋喃 为溶剂， 以72%的产率得到1-(4-methoxyphenylamino)-1-(naphthalen-1-yl)propan-2-one
  参考文献：
  名称：

  Electroreductive acylation of aromatic imines with acylimidazoles

  摘要：

  The intermolecular reductive coupling of aromatic imines with acylimidazoles was effected by electroreduction in the presence of chlorotrimethylsilane and gave a-amino-a-aryl ketones. This method was also effective for the synthesis of alpha-amino-alpha-aryl esters using methoxycarbonylimidazole as an electrophile. (c) 2007 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tet.2007.11.106

文献信息

• Electroreductive acylation of aromatic imines with acylimidazoles
  作者：Naoki Kise、Shinji Morimoto

  DOI：10.1016/j.tet.2007.11.106

  日期：2008.2

  The intermolecular reductive coupling of aromatic imines with acylimidazoles was effected by electroreduction in the presence of chlorotrimethylsilane and gave a-amino-a-aryl ketones. This method was also effective for the synthesis of alpha-amino-alpha-aryl esters using methoxycarbonylimidazole as an electrophile. (c) 2007 Elsevier Ltd. All rights reserved.