1-(phthalimido)-4,8,12-tris{N-[2,4,6-(trimethyl)benzenesulfonyl]}-15-N-[2,4,6-(trimethyl)benzenesulfonylamino]-4,8,12-triazapentadecane | 868836-27-5

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 异吲哚及其衍生物
• 英文名称: 1-(phthalimido)-4,8,12-tris{N-[2,4,6-(trimethyl)benzenesulfonyl]}-15-N-[2,4,6-(trimethyl)benzenesulfonylamino]-4,8,12-triazapentadecane
• 英文别名: 1-(phthalimido)-4,8,12-tris{N-[2,4,6-(trimethyl)benzenesulfonyl]}-15-N-[(2,4,6-trimethylbenzenesulfonyl)-amino]-4,8,12-triazapentadecane；N-[3-[3-[3-[3-(1,3-dioxoisoindol-2-yl)propyl-(2,4,6-trimethylphenyl)sulfonylamino]propyl-(2,4,6-trimethylphenyl)sulfonylamino]propyl-(2,4,6-trimethylphenyl)sulfonylamino]propyl]-2,4,6-trimethylbenzenesulfonamide
• CAS: 868836-27-5
• 化学式: C₅₆H₇₃N₅O₁₀S₄
• 分子量: 1104.49
• InChiKey: VCFDRTBNSKLGRU-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  9.9
• 重原子数：
  75
• 可旋转键数：
  24
• 环数：
  6.0
• sp3杂化的碳原子比例：
  0.43
• 拓扑面积：
  229
• 氢给体数：
  1
• 氢受体数：
  14

反应信息

• 作为反应物：
  描述：

  1-(phthalimido)-4,8,12-tris{N-[2,4,6-(trimethyl)benzenesulfonyl]}-15-N-[2,4,6-(trimethyl)benzenesulfonylamino]-4,8,12-triazapentadecane 在 sodium hydride 、 三乙胺 、 肼 作用下， 以 甲醇 、 二氯甲烷 、 N,N-二甲基甲酰胺 为溶剂， 反应 12.0h， 生成 11,15,19-tris{N-[2,4,6-(trimethyl)benzenesulfonyl]}-22-{N-[2,4,6-(trimethyl)benzenesulfonyl]-N-[(cyclopropyl)methyl]amino}-6-oxo-7,11,15,19-tetraazadocosanoic acid methyl ester
  参考文献：
  名称：

  Alkyl-Substituted Polyaminohydroxamic Acids:  A Novel Class of Targeted Histone Deacetylase Inhibitors

  摘要：

  The reversible acetylation of histones is critical for regulation of eukaryotic gene expression. The histone deacetylase inhibitors trichostatin (TSA, 1), MS-275 (2) and suberoylanilide, hydroxamic acid (SAHA, 3) arrest growth in transformed cells and in human tumor xenografts. However, 1-3 suffer from lack of specificity among the various HDAC isoforms, prompting us to design and synthesize polyaminohydroxamic acid (PAHA) derivatives 6-21. We felt that PAHAs would be selectively directed to chromatin and associated histones by the positively charged polyamine side chain. At 1 mu M, compounds 12, 15 and 20 inhibited HDAC by 74.86, 59.99 and 73.85%, respectively. Although 20 was a less potent HDAC inhibitor than 1, it was more potent than 2, more effective as an initiator of histone hyperacetylation, and significantly more effective than 2 at re-expressing p21(Waf1) in ML-1 leukemia cells. On the basis of these results, PAHAs 6-21 represent an important new chemical class of HDAC inhibitors.

  DOI：

  10.1021/jm0505009
• 作为产物：
  描述：

  N-(3-溴丙基)苯二胺 、 N¹,N⁴,N⁸,N¹¹-tetrakis(mesitylenesulfonyl)norspermine 在 sodium hydride 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 以65.7%的产率得到1-(phthalimido)-4,8,12-tris{N-[2,4,6-(trimethyl)benzenesulfonyl]}-15-N-[2,4,6-(trimethyl)benzenesulfonylamino]-4,8,12-triazapentadecane
  参考文献：
  名称：

  Alkyl-Substituted Polyaminohydroxamic Acids:  A Novel Class of Targeted Histone Deacetylase Inhibitors

  摘要：

  The reversible acetylation of histones is critical for regulation of eukaryotic gene expression. The histone deacetylase inhibitors trichostatin (TSA, 1), MS-275 (2) and suberoylanilide, hydroxamic acid (SAHA, 3) arrest growth in transformed cells and in human tumor xenografts. However, 1-3 suffer from lack of specificity among the various HDAC isoforms, prompting us to design and synthesize polyaminohydroxamic acid (PAHA) derivatives 6-21. We felt that PAHAs would be selectively directed to chromatin and associated histones by the positively charged polyamine side chain. At 1 mu M, compounds 12, 15 and 20 inhibited HDAC by 74.86, 59.99 and 73.85%, respectively. Although 20 was a less potent HDAC inhibitor than 1, it was more potent than 2, more effective as an initiator of histone hyperacetylation, and significantly more effective than 2 at re-expressing p21(Waf1) in ML-1 leukemia cells. On the basis of these results, PAHAs 6-21 represent an important new chemical class of HDAC inhibitors.

  DOI：

  10.1021/jm0505009

文献信息

• Alkyl-Substituted Polyaminohydroxamic Acids:  A Novel Class of Targeted Histone Deacetylase Inhibitors
  作者：Sheeba Varghese、Deepak Gupta、Tiffany Baran、Anchalee Jiemjit、Steven D. Gore、Robert A. Casero,、Patrick M. Woster

  DOI：10.1021/jm0505009

  日期：2005.10.1

  The reversible acetylation of histones is critical for regulation of eukaryotic gene expression. The histone deacetylase inhibitors trichostatin (TSA, 1), MS-275 (2) and suberoylanilide, hydroxamic acid (SAHA, 3) arrest growth in transformed cells and in human tumor xenografts. However, 1-3 suffer from lack of specificity among the various HDAC isoforms, prompting us to design and synthesize polyaminohydroxamic acid (PAHA) derivatives 6-21. We felt that PAHAs would be selectively directed to chromatin and associated histones by the positively charged polyamine side chain. At 1 mu M, compounds 12, 15 and 20 inhibited HDAC by 74.86, 59.99 and 73.85%, respectively. Although 20 was a less potent HDAC inhibitor than 1, it was more potent than 2, more effective as an initiator of histone hyperacetylation, and significantly more effective than 2 at re-expressing p21(Waf1) in ML-1 leukemia cells. On the basis of these results, PAHAs 6-21 represent an important new chemical class of HDAC inhibitors.