N-ethyl-S-phenylsulfenamide | 24380-80-1

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: N-ethyl-S-phenylsulfenamide
• 英文别名: Phenylthioethylamine；N-Ethyl-benzolsulfenamid；Ethylaminothiophenyl；N-phenylsulfanylethanamine
• CAS: 24380-80-1
• 化学式: C₈H₁₁NS
• 分子量: 153.248
• InChiKey: WVWUYHNEQQWRPL-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.2
• 重原子数：
  10
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.25
• 拓扑面积：
  37.3
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  N-ethyl-S-phenylsulfenamide 、 苯甲醚 在 硫酸 、 三氟乙酸 作用下， 反应 0.5h， 以74%的产率得到1-甲氧基-4-(苯硫基)-苯
  参考文献：
  名称：

  Takeuchi, Hiroshi; Oya, Hiromo; Yanase, Takehiro, Journal of the Chemical Society. Perkin transactions II, 1994, # 4, p. 827 - 834

  摘要：

  DOI：
• 作为产物：
  描述：

  苯次磺酰氯 在 三乙胺 作用下， 以 乙醇 、 二氯甲烷 为溶剂， 反应 3.0h， 生成 N-ethyl-S-phenylsulfenamide
  参考文献：
  名称：

  Tanaka; Azuma; Fang, Synlett, 2000, # 1, p. 33 - 36

  摘要：

  DOI：

文献信息

• SYNTHESIS OF FLUORO HEMIACETALS VIA TRANSITION METAL-CATALYZED FLUORO ESTER AND CARBOXAMIDE HYDROGENATION
  申请人：Triad National Security, LLC

  公开号：US20200308089A1

  公开（公告）日：2020-10-01

  This application is directed to use of transition metal-ligand complexes to hydrogenate fluorinated esters and carboxamides into fluorinated hemiacetals. Methods for synthesis of certain ligands are also provided.

  这项应用涉及使用过渡金属配体络合物将氟化酯和羧酰胺加氢成氟代半缩醛。还提供了合成某些配体的方法。
• The sulphur(<scp>II</scp>)–nitrogen bond. Part III. The synthesis of the sulphur-(<scp>II</scp>)–nitrogen bond from sulphenates
  作者：D. A. Armitage、M. J. Clark、A. C. Kinsey

  DOI：10.1039/j39710003867

  日期：——

  wide variety of sulphur(II)–nitrogen compounds. Sulphenamides are obtained in high yield from primary or secondary amines while the NN-dialkylsulphenamides can be prepared from NN-dialkylaminosilanes. With N-alkylaminosilanes, however, a mixture of N-alkyl and N-alkyl-N-trimethylsilylsulphenamides result, due to cleavage of Si–N and N–H bonds. N-Silylsulphenamides can be prepared from disilazanes, while

  邻苯甲基苯甲酸甲酯已被用于制备多种硫（II）-氮化合物。亚磺酰胺从伯胺或仲胺以高收率获得，而N N-二烷基亚磺酰胺可从N N-二烷基氨基硅烷制备。与Ñ -alkylaminosilanes，然而，混合物ñ -烷基和ñ -烷基- Ñ -trimethylsilylsulphenamides结果，由于Si的N和N-H键的断裂。可以从二硅氮烷制备N-甲硅烷基苯甲酰胺，而从N-甲基苯磺基苯甲酰胺获得N-甲基双苯磺基苯乙酰亚胺MeN（SPh）2。
• [EN] 3-[(1H-PYRAZOL-4-YL)OXY]PYRAZIN-2-AMINE COMPOUNDS AS HPK1 INHIBITOR AND USE THEREOF<br/>[FR] COMPOSÉS DE 3-[(1H-PYRAZOL-4-YL)OXY]PYRAZIN-2-AMINE UTILISÉS EN TANT QU'INHIBITEUR DE HPK1 ET LEUR UTILISATION
  申请人：BEIGENE LTD

  公开号：WO2022068848A1

  公开（公告）日：2022-04-07

  Disclosed herein is 3- [ (1H-pyrazol-4-yl) oxy] pyrazin-2-amine compounds of Formula (I), or a stereoisomer thereof, or a pharmaceutically acceptable salt thereof, and pharmaceutical compositions comprising thereof. Also disclosed is a method of modulating, e.g., inhibiting or treating HPK1 related disorders or diseases including cancer by using the compound disclosed herein

  本文揭示了化合物3-[(1H-吡唑-4-基)氧基]吡嗪-2-胺的公式(I)或其立体异构体，或其药学上可接受的盐，以及包含它们的制药组合物。还揭示了使用本文所揭示的化合物来调节，例如，抑制或治疗与HPK1相关的疾病或疾病，包括癌症的方法。
• 1-substituted-3-acylpyrrole derivatives, process for their preparation and platelet aggregation inhibiting agents containing them
  申请人：TEIJIN LIMITED

  公开号：EP0002392A2

  公开（公告）日：1979-06-13

  The invention provides 1-substituted-3-acylpyrroles of the formula:- wherein is an optionaliy substituted phenyl group, a cycloalkyl or cycloalkenyl group. branched alkyl group, or optionally substituted heterocyclic group, R, is hydrogen or an alkyl group and R2, R3 and R4, are such that the substituent linked to the N-atom in the 1-position contains an alcoholic hydroxyl proup. an ether group, a thioether group or a functional group derived from oxidation of these groups linked to the N-atorn through a chain of two carbon atoms. The compounds of the invention, unlike known 3-acyl-1- substituted pyrrole derivatives, have high platelet aggregation inhibiting activities and low antiinflammatory activities. They may be made by acylating a 1-substituted pyrrole in the 3-position by reaction with an anhydride or halide of a carboxylic acid of the formula COOH, in the presence of an acid catalyst, and if desired subjecting the products to oxidation, hydrolysis, amidation or acetal-forming reaction.

  本发明提供了式中的 1-取代-3-酰基吡咯：- 1-取代-3-酰基吡咯 其中，R2、R3 和 R4 是任选取代的苯基、环烷基或环烯基、支链烷基或任选取代的杂环基团；R 是氢或烷基；R2、R3 和 R4 是这样的取代基：与 1 位 N 原子相连的取代基含有醇羟基、醚基、硫醚基或由这些基团通过两个碳原子链与 N 原子相连的氧化衍生的官能团。 与已知的 3-酰基-1-取代的吡咯衍生物不同，本发明的化合物具有较高的血小板聚集抑制活性和较低的抗炎活性。 本发明化合物的制备方法是：在酸催化剂存在下，通过与式 COOH 的羧酸的酸酐或卤化物反应，使 1-取代的吡咯在 3 位上酰化，并根据需要使产物进行氧化、水解、酰胺化或缩醛生成反应。
• Carboximidamide derivatives
  申请人：KIRIN BEER KABUSHIKI KAISHA

  公开号：EP0388528A2

  公开（公告）日：1990-09-26

  Novel carboximidamide derivatives represented by the following formula (A) and acid adduct salts thereof are disclosed: wherein all the substituents have the same meanings as defined above. N-cyano-pyridinecarboximidate compounds represented by the following formula (II) whiich are the intermediates for preparing of N-cyano-N′-substituted-­pyridinecarboximidamide derivatives wherein the substituent B in the above described formula (A) is pyridine are also disclosed: wherein all the substituents have the same meanings as defined above. The process for preparing the compounds, the pharmaceutical agents comprising the compound having vasodilating effect, and the therapeutic method of dosing the compound on patients for therapy are also disclosed.

  本发明公开了由下式（A）代表的新型羧亚酰胺衍生物及其酸加成盐： 其中所有取代基的含义与上述定义相同。 还公开了下式(II)代表的 N-氰基吡啶甲脒化合物，它们是制备 N-氰基-N′-取代的吡啶甲脒衍生物的中间体，其中上述式(A)中的取代基 B 为吡啶： 其中所有取代基的含义与上述定义相同。 本发明还公开了制备上述化合物的工艺、包含具有血管扩张作用的化合物的药物制剂以及将该化合物用于患者治疗的治疗方法。