compound 12 | 924277-08-7

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 二苯乙烯类
• 英文名称: compound 12
• 英文别名: 6-(Dimethylamino)-1-(3-ethyl-2-methoxyquinolin-6-yl)-1,2-diphenylhexan-2-ol
• CAS: 924277-08-7
• 化学式: C₃₂H₃₈N₂O₂
• 分子量: 482.666
• InChiKey: LDUIWNJBUYOYCG-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6.8
• 重原子数：
  36
• 可旋转键数：
  11
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.34
• 拓扑面积：
  45.6
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  1-(3-Ethyl-2-methoxyquinolin-6-yl)-1,2-diphenylpent-4-en-2-ol 、 一氧化碳 、 二甲胺 在 (1Z,5Z)-cycloocta-1,5-diene,iridium,tetrafluoroborate 、 bis(1,5-cyclooctadiene)rhodium(I) tetrafluoroborate 氢气 、 4,5-双二苯基膦-9,9-二甲基氧杂蒽 作用下， 以 四氢呋喃 、 甲醇 为溶剂， 反应 48.0h， 生成 compound 12
  参考文献：
  名称：

  [EN] QUINOLINE DERIVATIVES AS ANTIBACTERIAL AGENTS
  [FR] DERIVES DE QUINOLEINE UTILISES COMME AGENTS ANTIBACTERIENS

  摘要：

  公开号：

  WO2007014941A3

文献信息

• QUINOLINE DERIVATIVES AS ANTIBACTERIAL AGENTS
  申请人：Janssen Pharmaceutica NV

  公开号：EP1912648B1

  公开（公告）日：2013-04-10
• Quinoline Derivatives as Antibacterial Agents
  申请人：Guillemont Jerome Emile Georges

  公开号：US20080207687A1

  公开（公告）日：2008-08-28

  Use of a compound for the manufacture of a medicament for the treatment of a bacterial infection provided that the bacterial infection is other than a Mycobacterial infection, said compound being a compound of formula (I) a pharmaceutically acceptable acid or base addition salt, a quaternary amine, a stereochemically isomeric form, a tautomeric form or a N-oxide form thereof, wherein R 1 is hydrogen, halo, haloalkyl, cyano, hydroxy, Ar, Het, alkyl, alkyloxy, alkylthio, alkyloxyalkyl, alkylthioalkyl, Ar-alkyl or di(Ar)alkyl; p is 1 to 3; s is 0 to 4; R 2 is hydrogen; halo; alkyl; hydroxy; mercapto; optionally substituted alkyloxy; alkyloxyalkyloxy; alkylthio; mono or di(alkyl)amino wherein alkyl may optionally be substituted; Ar; Het or a radical of formula R 3 is alkyl, Ar, Ar-alkyl, Het or Het-alkyl; q is 0 to 4; R 4 and R 5 each independently are hydrogen, alkyl or benzyl; or R 4 and R 5 may be taken together including the N to which they are attached; R 6 is hydrogen, halo, haloalkyl, hydroxy, Ar, alkyl, alkyloxy, alkylthio, alkyloxyalkyl, alkylthioalkyl, Ar-alkyl or di(Ar)alkyl; or two vicinal R 6 radicals may be taken together to form together with the phenyl ring to which they are attached a naphthyl; r is 1 to 5; R 7 is hydrogen, alkyl, Ar or Het; R 8 is hydrogen, alkyl, hydroxyl, aminocarbonyl, mono- or di(alkyl)aminocarbonyl, Ar, Het, alkyl substituted with one or two Het, alkyl substituted with one or two Ar, Het-C(═O)— or Ar—C(═O)—; provided that when the R 3 bearing radical is placed in position 3 of the quinoline moiety; R 7 is placed in position 4 and R 2 is placed in position 2 and represents hydrogen, hydroxy, mercapto, alkyloxy, alkyloxyalkyloxy, alkylthio, mono or di(alkyl)amino or a radical of formula then s is 1 to 4.
• US8802671B2
  申请人：——

  公开号：US8802671B2

  公开（公告）日：2014-08-12
• [EN] QUINOLINE DERIVATIVES AS ANTIBACTERIAL AGENTS<br/>[FR] DERIVES DE QUINOLEINE UTILISES COMME AGENTS ANTIBACTERIENS
  申请人：JANSSEN PHARMACEUTICA NV

  公开号：WO2007014941A3

  公开（公告）日：2007-03-29