Ethyl 7-hydroxy-9-oxo-1,2,3,3a-tetrahydropyrrolo[2,1-b][1,3]benzoxazine-6-carboxylate | 537034-53-0

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并恶嗪类
• 英文名称: Ethyl 7-hydroxy-9-oxo-1,2,3,3a-tetrahydropyrrolo[2,1-b][1,3]benzoxazine-6-carboxylate
• CAS: 537034-53-0
• 化学式: C₁₄H₁₅NO₅
• 分子量: 277.277
• InChiKey: MEAQVZFSPUVSSA-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.2
• 重原子数：
  20
• 可旋转键数：
  3
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.43
• 拓扑面积：
  76.1
• 氢给体数：
  1
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  Ethyl 7-hydroxy-9-oxo-1,2,3,3a-tetrahydropyrrolo[2,1-b][1,3]benzoxazine-6-carboxylate 在 4-二甲氨基吡啶 、 水 、 1-羟基苯并三唑 、 盐酸-N-乙基-Nˊ-(3-二甲氨基丙基)碳二亚胺 、 三乙胺 、 potassium hydroxide 作用下， 以 甲醇 、 N,N-二甲基甲酰胺 为溶剂， 反应 5.5h， 生成
  参考文献：
  名称：

  Benzoxazinones as potent positive allosteric AMPA receptor modulators: Part I

  摘要：

  AMPA receptors (AMPARs) are an increasingly important therapeutic target in the CNS. Aniracetam, the first identified potentiator of AMPARs, led to the rigid and more potent CX614. This lead molecule was optimized in order to increase affinity towards the AMPA receptor. The substitution of the dioxine with a benzoxazinone ring system increased the activity and allowed further investigation of the sidechain SAR. (C) 2011 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2011.05.026
• 作为产物：
  描述：

  2,5-二羟基对苯二甲酸乙酯 在 盐酸 作用下， 反应 1.12h， 生成 Ethyl 7-hydroxy-9-oxo-1,2,3,3a-tetrahydropyrrolo[2,1-b][1,3]benzoxazine-6-carboxylate
  参考文献：
  名称：

  取代的苯并恶嗪酮类作为有效的正变构AMPA受体调节剂：第二部分

  摘要：

  AMPA受体（AMPAR）是中枢神经系统的重要治疗靶标。合成并评估了一系列具有良好或非常好的体外活性的正苯胺酮衍生物，作为正变构AMPAR调节剂。与我们的先导分子CX614相比，在苯并恶嗪酮片段上选择适当的取代基可以显着提高对AMPA受体的亲和力。

  DOI：

  10.1016/j.bmcl.2011.05.024

文献信息

• US7799913B2
  申请人：——

  公开号：US7799913B2

  公开（公告）日：2010-09-21
• [EN] CARBONYLBENZOXAZINE COMPOUNDS FOR ENHANCING GLUTAMATERGIC SYNAPTIC RESPONSES<br/>[FR] COMPOSES CARBONYLBENZOXAZINIQUES AMELIORANT LES REPONSES SYNAPTIQUES GLUTAMATERGIQUES
  申请人：CORTEX PHARMA INC

  公开号：WO2003045315A2

  公开（公告）日：2003-06-05

  This invention relates to the prevention and treatment of cerebral insufficiency, including enhancement of receptor functioning in synapses in brain networks responsible for higher order behaviors. These brain networks are involved in cognitive abilities related to memory impairment, such as is observed in a variety of dementias, and in imbalances in neuronal activity between different brain regions, as is suggested in disorders such as Parkinson's disease, schizophrenia and affective disorders. In a particular aspect, the present invention relates to compounds useful for treatment of such conditions, and methods of using these compounds for such treatment.
• Substituted benzoxazinones as potent positive allosteric AMPA receptor modulators: Part II
  作者：Rudolf Mueller、Stanislaw Rachwal、Martina E. Tedder、Yong-Xin Li、Sheng Zhong、Aidan Hampson、Jolanta Ulas、Mark Varney、Lena Nielsson、Gary Rogers

  DOI：10.1016/j.bmcl.2011.05.024

  日期：2011.7

  AMPA receptors (AMPARs) are an important therapeutic target in the CNS. A series of substituted benzoxazinone derivatives with good to very good in vitro activity as positive allosteric AMPAR modulators was synthesized and evaluated. The appropriate substituent choice on the benzoxazinone fragment improved the affinity towards the AMPA receptor significantly in comparison to our lead molecule CX614

  AMPA受体（AMPAR）是中枢神经系统的重要治疗靶标。合成并评估了一系列具有良好或非常好的体外活性的正苯胺酮衍生物，作为正变构AMPAR调节剂。与我们的先导分子CX614相比，在苯并恶嗪酮片段上选择适当的取代基可以显着提高对AMPA受体的亲和力。
• Benzoxazinones as potent positive allosteric AMPA receptor modulators: Part I
  作者：Rudolf Mueller、Yong-Xin Li、Aidan Hampson、Sheng Zhong、Clayton Harris、Christopher Marrs、Stanislaw Rachwal、Jolanta Ulas、Lena Nielsson、Gary Rogers

  DOI：10.1016/j.bmcl.2011.05.026

  日期：2011.7

  AMPA receptors (AMPARs) are an increasingly important therapeutic target in the CNS. Aniracetam, the first identified potentiator of AMPARs, led to the rigid and more potent CX614. This lead molecule was optimized in order to increase affinity towards the AMPA receptor. The substitution of the dioxine with a benzoxazinone ring system increased the activity and allowed further investigation of the sidechain SAR. (C) 2011 Elsevier Ltd. All rights reserved.