[(1S)-1-[(4R)-2-oxo-1,3-oxazolidin-4-yl]-2-phenylmethoxyethyl] benzoate | 479690-54-5

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: [(1S)-1-[(4R)-2-oxo-1,3-oxazolidin-4-yl]-2-phenylmethoxyethyl] benzoate
• CAS: 479690-54-5
• 化学式: C₁₉H₁₉NO₅
• 分子量: 341.4
• InChiKey: DQVKPGWQSKPQHR-IAGOWNOFSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.7
• 重原子数：
  25
• 可旋转键数：
  8
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.26
• 拓扑面积：
  73.9
• 氢给体数：
  1
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  [(1S)-1-[(4R)-2-oxo-1,3-oxazolidin-4-yl]-2-phenylmethoxyethyl] benzoate 、 potassium carbonate 、 甲醇 生成 (4R)-4-[(1S)-1-hydroxy-2-phenylmethoxyethyl]-1,3-oxazolidin-2-one
  参考文献：
  名称：

  MCCOMBIE, S. W.;NAGABHUSHAN, T. L., TETRAHEDRON. LETT., 28,(1987) N 45, 5395-5398

  摘要：

  DOI：
• 作为产物：
  描述：

  (2s,3r)-Benzoylcarbamic acid [3-(benzyloxymethyl)oxiranyl]methyl ester 、 sodium 以86%的产率得到
  参考文献：
  名称：

  MCCOMBIE, S. W.;NAGABHUSHAN, T. L., TETRAHEDRON. LETT., 28,(1987) N 45, 5395-5398

  摘要：

  DOI：

文献信息

• Beta-benzyloxyaspartate derivatives with amino group on benzene ring
  申请人：Shimamoto Keiko

  公开号：US20070238783A1

  公开（公告）日：2007-10-11

  L-threo-β-benzyloxyaspartate derivatives having a substituent on the benzene ring, represented by the following formula (1): wherein R is hydrogen, a linear or branched lower aliphatic acyl group with the acyl portion optionally substituted, an alicyclic acyl group, an aromatic acyl group with a substituent on the aromatic ring, an amino acid-derived group or a biotin derivative-derived group, having an amino substituent on the benzene ring, and salts thereof, which can easily bind to affinity column chromatography carriers as ligands of glutamate transporter proteins.

  具有苯环上取代基的L-单体-β-苄氧基天冬氨酸衍生物，化学式如下（1）：其中R为氢、具有酰基部分可选取代的线性或支链低级脂肪酰基、脂环酰基、苯环上具有取代基的芳香酰基、氨基酸衍生物基团或生物素衍生物基团，其在苯环上具有氨基取代基，以及其盐。该衍生物可以作为谷氨酸转运蛋白的配体，容易结合到亲和柱色谱载体上。
• MCCOMBIE, S. W.;NAGABHUSHAN, T. L., TETRAHEDRON. LETT., 28,(1987) N 45, 5395-5398
  作者：MCCOMBIE, S. W.、NAGABHUSHAN, T. L.

  DOI：——

  日期：——
• BETA-BENZYLOXYASPARTATE DERIVATIVES WITH AMINO GROUP ON BENZENE RING
  申请人：Suntory Holdings Limited

  公开号：EP1397370B1

  公开（公告）日：2014-07-23
• Beta benzyloxyaspartate derivatives with amino group on benzene ring
  申请人：——

  公开号：US20040242652A1

  公开（公告）日：2004-12-02

  L-threo-&bgr;-benzyloxyaspartate derivatives having a substituent on the benzene ring, represented by the following formula (1): 1 wherein R is hydrogen, a linear or branched lower aliphatic acyl group with the acyl portion optionally substituted, an alicyclic acyl group, an aromatic acyl group with a substituent on the aromatic ring, an amino acid-derived group or a biotin derivative-derived group, having an amino substituent on the benzene ring, and salts thereof, which can easily bind to affinity column chromatography carriers as ligands of glutamate transporter proteins.
• US7247652B2
  申请人：——

  公开号：US7247652B2

  公开（公告）日：2007-07-24