N-Benzyl-5-methylheptan-1-amine | 193287-81-9

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: N-Benzyl-5-methylheptan-1-amine
• CAS: 193287-81-9
• 化学式: C₁₅H₂₅N
• 分子量: 219.37
• InChiKey: DBBKQRHEXFYXIJ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.4
• 重原子数：
  16
• 可旋转键数：
  8
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.6
• 拓扑面积：
  12
• 氢给体数：
  1
• 氢受体数：
  1

文献信息

• CEREBLON E3 LIGASE INHIBITORS
  申请人：REGENTS OF THE UNIVERSITY OF MICHIGAN

  公开号：US20220388978A1

  公开（公告）日：2022-12-08

  The present disclosure provides compounds represented by Formula I: wherein R2a, R2b, R2c, R2d, R3, R13, and Z are as defined in the specification, and the salts and solvates thereof. Compounds of Formula I are cereblon (CRBN) ubiquitination inhibitors or monofunctional synthetic intermediates that can be used to prepare PROTAC molecules. CRBN ubiquitination inhibitors and PROTAC molecules are useful for the treatment of cancer and other diseases.