methyl 2-ethoxy-3-(3'-methylaminomethylbiphenyl-4-yl)propionate | 692780-68-0

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: methyl 2-ethoxy-3-(3'-methylaminomethylbiphenyl-4-yl)propionate
• 英文别名: methyl 2-ethoxy-3-[4-[3-(methylaminomethyl)phenyl]phenyl]propanoate
• CAS: 692780-68-0
• 化学式: C₂₀H₂₅NO₃
• 分子量: 327.423
• InChiKey: FGNWYHWXXOYCMV-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.4
• 重原子数：
  24
• 可旋转键数：
  9
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.35
• 拓扑面积：
  47.6
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  methyl 2-ethoxy-3-(3'-methylaminomethylbiphenyl-4-yl)propionate 、 碳酸二叔丁酯 在 三乙胺 作用下， 以 二氯甲烷 为溶剂， 以85%的产率得到methyl 3-{3'-[(tert-butoxycarbonylmethylamino)methyl]biphenyl-4-yl}-2-ethoxypropionate
  参考文献：
  名称：

  [EN] BIPHENYL COMPOUNDS WHICH ACTIVATE PPAR-GAMMA TYPE RECEPTORS AND USE THEREOF IN COSMETIC OR PHARMACEUTICAL COMPOSITIONS
  [FR] NOUVEAUX COMPOSES BI-AROMATIQUES QUI ACTIVENT DES RECEPTEURS DE TYPE PPAR DOLLAR G(Y), ET LEUR UTILISATION DANS DES COMPOSITIONS COSMETIQUES OU PHARMACEUTIQUES

  摘要：

  公开号：

  WO2004048351A3

文献信息

• Novel biaromatic compounds which activate PPARgamma type receptors and cosmetic/pharmaceutical compositions comprised thereof
  申请人：Clary Laurence

  公开号：US20060004048A1

  公开（公告）日：2006-01-05

  Novel biaromatic compounds having the structural formula (I) below: are formulated into pharmaceutical compositions suited for administration in human or veterinary medicine (in dermatology, and also in the fields of cardiovascular diseases, immune diseases and/or diseases associated with lipid metabolism), or, alternatively, into cosmetic compositions.

  具有以下结构式（I）的新型双芳香化合物被制成适用于人类或兽医药物的制剂（在皮肤科，以及心血管疾病，免疫疾病和/或与脂质代谢有关的疾病领域），或者，制成化妆品制剂。
• Novel biaromatic compounds which activate PPARy type receptors and cosmetic/pharmaceutical compositions comprised thereof
  申请人：Clary Laurence

  公开号：US20080070957A1

  公开（公告）日：2008-03-20

  Novel biaromatic compounds having the structural formula (I) below: are formulated into pharmaceutical compositions suited for administration in human or veterinary medicine (in dermatology, and also in the fields of cardiovascular diseases, immune diseases and/or diseases associated with lipid metabolism), or, alternatively, into cosmetic compositions.

  具有以下结构式（I）的新型双芳香族化合物被制成适用于人类或兽医药物（在皮肤科以及心血管疾病、免疫性疾病和/或与脂质代谢相关的疾病领域）的制剂，或者是化妆品制剂。
• Biaromatic compounds which activate PPARgamma type receptors and cosmetic/pharmaceutical compositions comprised thereof
  申请人：Galderma Research & Development

  公开号：US07285568B2

  公开（公告）日：2007-10-23

  Novel biaromatic compounds having the structural formula (I) below: are formulated into pharmaceutical compositions suited for administration in human or veterinary medicine (in dermatology, and also in the fields of cardiovascular diseases, immune diseases and/or diseases associated with lipid metabolism), or, alternatively, into cosmetic compositions.

  具有以下结构式（I）的新型双芳香化合物被制成适用于人类或兽医学（在皮肤科，以及心血管疾病，免疫疾病和/或与脂质代谢有关的疾病领域）的制药组合物，或者制成化妆品组合物。
• Biaromatic compounds which activate PPARγ type receptors and cosmetic/pharmaceutical compositions comprised thereof
  申请人：Galderma Research & Development

  公开号：US07582663B2

  公开（公告）日：2009-09-01

  Novel biaromatic compounds having the structural formula (I) below: are formulated into pharmaceutical compositions suited for administration in human or veterinary medicine (in dermatology, and also in the fields of cardiovascular diseases, immune diseases and/or diseases associated with lipid metabolism), or, alternatively, into cosmetic compositions.

  具有以下结构式（I）的新型双芳香化合物被制成适用于人类或兽医药物（在皮肤科，以及心血管疾病，免疫疾病和/或与脂质代谢有关的疾病领域），或者制成化妆品组合物。
• US7285568B2
  申请人：——

  公开号：US7285568B2

  公开（公告）日：2007-10-23