potassium 4-nitrophenylsulfonate | 4346-49-0

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: potassium 4-nitrophenylsulfonate
• 英文别名: potassium p-nitrobenzenesulfonate；Kalium-4-nitro-benzol-sulfonat；Potassium;4-nitrobenzenesulfonate；potassium;4-nitrobenzenesulfonate
• CAS: 4346-49-0
• 化学式: C₆H₄NO₅S*K
• 分子量: 241.266
• InChiKey: FERODINMFGAWHO-UHFFFAOYSA-M

计算性质

• 辛醇/水分配系数(LogP)：
  -2.5
• 重原子数：
  14
• 可旋转键数：
  0
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  111
• 氢给体数：
  0
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  potassium 4-nitrophenylsulfonate 、 反应 0.15h， 生成 benzoic 4-nitrobenzenesulfonic anhydride
  参考文献：
  名称：

  A Facile Procedure for Preparation of Carboxylic Sulfonic Anhydrides Under Solvent-Free Conditions

  摘要：

  A manipulatively one-pot and rapid method for the synthesis of carboxylic sulfonic anhydride from acid chloride or sulfonyl chloride and potassium salt of carboxylic or sulfonic acid under solvent-free conditions is reported. The reaction has been carried out in excellent yield and short reaction time in the presence of DABCO under solvent-free conditions.

  DOI：

  10.1080/10426500307785
• 作为产物：
  描述：

  对硝基苯磺酰氯 在 potassium hydroxide 作用下， 以 水 为溶剂， 反应 3.0h， 以98%的产率得到potassium 4-nitrophenylsulfonate
  参考文献：
  名称：

  的合成，结构和的水解稳定性Ñ，小号-bridging硫代thymidylyl-3'，5'-胸苷类似物†

  摘要：

  甲3'- Ñ，5'-小号-bridging硫代thymidylyl-3'的类似物，5'-胸苷水溶液条件下合成。1 H NMR构象测量表明3'- N-取代的脱氧核糖环偏向“北” RNA样构象。在90°C的pH范围1.3–10.9下测量类似物水解的速率常数。pH-log  k obs谱显示约7到10（t 1/ 2〜13天）之间的非pH依赖性区域。在酸性条件下，k obs显示出对[H 3 O + ]的一阶依赖性。

  DOI：

  10.1039/c6ob01270a

文献信息

• Selective introduction of sulfo groups into aromatic nitro compounds
  作者：Mikhail D. Dutov、Olga V. Serushkina、Svyatoslav A. Shevelev、A. Lyssenko

  DOI：10.1016/j.mencom.2007.11.017

  日期：2007.11

  A new reaction has been found, viz. oxidative destruction of nitro-substituted sulfones ArSO2CH2CO2Me to give sulfonic acids ArSO3H on treatment with 70% HNO3; in addition, di(arylsulfonyl)furoxans are formed as by-products.

  已经发现了新的反应，即。硝基取代的砜ArSO2CH2CO2Me的氧化破坏，经70％HNO3处理后生成磺酸ArSO3H。另外，形成二（芳基磺酰基）呋喃烷作为副产物。
• Late-stage sulfonic acid/sulfonate formation from sulfonamides via sulfonyl pyrroles
  作者：Tomoya Ozaki、Hideki Yorimitsu、Gregory J.P. Perry

  DOI：10.1016/j.tet.2022.132830

  日期：2022.7

  Sulfonamides are present in a range of useful molecules, such as drugs and agrochemicals. In recent years, the functionalization of sulfonamides via S–N bond cleavage has received increased attention. In this report, we detail an accessible and low-cost route for transforming primary sulfonamides into the corresponding sulfonic acids/sulfonates via sulfonyl pyrroles. The reaction is demonstrated with

  磺胺类药物存在于一系列有用的分子中，例如药物和农用化学品。近年来，磺胺类药物通过 S-N 键断裂的功能化受到越来越多的关注。在本报告中，我们详细介绍了一种通过磺酰吡咯将伯磺酰胺转化为相应的磺酸/磺酸盐的低成本途径。该反应在一系列底物（包括芳基和烷基磺酰胺）以及几种含磺酰胺药物分子的后期官能化中得到证实。
• Bunting, John W.; Mason, Jacqueline M.; Heo, Christina K. M., Journal of the Chemical Society. Perkin transactions II, 1994, # 11, p. 2291 - 2300
  作者：Bunting, John W.、Mason, Jacqueline M.、Heo, Christina K. M.

  DOI：——

  日期：——
• New procedure for nucleophilic sulfonation of aromatic nitro compounds: Destructive oxidation of S-arylthioglycolic acids esters
  作者：M. D. Dutov、O. V. Serushkina、S. A. Shevelev

  DOI：10.1134/s1070428007080131

  日期：2007.8

  A new reaction was discovered: oxidative destruction of sulfides of ArSCH(2)CO(2)Me type to sulfonic acids ArSO(3)H effected by 70% HNO(3). This reaction was used to introduce an SO(3)H group instead of aromatic nitro group activated only by meta-substituents: At treating with HSCH(2)CO(2)Me + K(2)CO(3) the NO(2) group was substituted to form ArSCH(2)CO(2)Me with subsequent transformation into ArSO(3)H. p-Fluoronitrobenzene behaved similarly (with replacement of the fluorine).
• A Facile Procedure for Preparation of Carboxylic Sulfonic Anhydrides Under Solvent-Free Conditions
  作者：A. R. Hajipour、Gh. Mazloumi

  DOI：10.1080/10426500307785

  日期：2003.1.1

  A manipulatively one-pot and rapid method for the synthesis of carboxylic sulfonic anhydride from acid chloride or sulfonyl chloride and potassium salt of carboxylic or sulfonic acid under solvent-free conditions is reported. The reaction has been carried out in excellent yield and short reaction time in the presence of DABCO under solvent-free conditions.