3-Hydroxy-1-(1-hydroxyethyl)-2-methyl-4(1H)-pyridinone | 286014-73-1

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 英文名称: 3-Hydroxy-1-(1-hydroxyethyl)-2-methyl-4(1H)-pyridinone
• 英文别名: 3-hydroxy-1-(1-hydroxyethyl)-2-methylpyridin-4-one
• CAS: 286014-73-1
• 化学式: C₈H₁₁NO₃
• 分子量: 169.18
• InChiKey: QNERVRBEUNUMOV-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.4
• 重原子数：
  12
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.38
• 拓扑面积：
  60.8
• 氢给体数：
  2
• 氢受体数：
  4

文献信息

• Use of phanquinone for the treatment of Alzheimer's disease
  申请人：Xilinas Michel

  公开号：US20050003018A1

  公开（公告）日：2005-01-06

  The use of phanquinone for the manufacture of a pharmaceutical composition for the prevention or the treatment of Alzheimer's disease is disclosed. Also methods of treatment or prevention of Alzheimer's disease are disclosed.

  本发明公开了使用吩醌制造预防或治疗阿尔茨海默病的药物组合物。还公开了治疗或预防阿尔茨海默病的方法。
• Method for treating Alzheimer's disease
  申请人：——

  公开号：US20040265847A1

  公开（公告）日：2004-12-30

  The present invention is directed to methods for treating Alzheimer's Disease by modulating divalent cation, trivalent cation and/or heparin interaction with amyloid precursor protein (APP). In particular, the present invention is directed to methods for treating Alzheimer's Disease by administering to a patient with Alzheimer's Disease a therapeutically effective amount of a zinc binding agent for modulating the interaction of zinc and/or heparin with APP and thereby preventing the aberrant processing of APP.

  本发明涉及通过调节二价阳离子、三价阳离子和/或肝素与淀粉样前体蛋白（APP）的相互作用来治疗阿尔茨海默病的方法。特别是，本发明涉及通过向阿尔茨海默病患者施用治疗有效量的锌结合剂治疗阿尔茨海默病的方法，该锌结合剂用于调节锌和/或肝素与APP的相互作用，从而防止APP的异常处理。
• A METHOD FOR ASSAYING AND TREATING ALZHEIMER'S DISEASE
  申请人：THE UNIVERSITY OF MELBOURNE

  公开号：EP0613560B1

  公开（公告）日：1998-10-21
• USE OF THE CHELATING AGENT CLIOQUINOL FOR THE MANUFACTURE OF A PHARMACEUTICAL COMPOSITION FOR THE TREATMENT OF ALZHEIMER'S DISEASE
  申请人：P.N. GEROLYMATOS S.A.

  公开号：EP0959888B1

  公开（公告）日：2001-09-05
• USE OF PHANQUINONE FOR THE TREATMENT OF ALZHEIMER'S DISEASE
  申请人：P.N. GEROLYMATOS S.A.

  公开号：EP1007040B1

  公开（公告）日：2002-05-08