diisopropyl(2-oxobenzo[d]oxazol-3(2H)-yl)phosphonate | 1417780-46-1

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并恶唑类
• 英文名称: diisopropyl(2-oxobenzo[d]oxazol-3(2H)-yl)phosphonate
• 英文别名: 3-[Oxido-di(propan-2-yloxy)phosphaniumyl]-1,3-benzoxazol-2-one；3-[oxido-di(propan-2-yloxy)phosphaniumyl]-1,3-benzoxazol-2-one
• CAS: 1417780-46-1
• 化学式: C₁₃H₁₈NO₅P
• 分子量: 299.263
• InChiKey: KSWOZXKAYAGRPL-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.4
• 重原子数：
  20
• 可旋转键数：
  5
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.46
• 拓扑面积：
  71.1
• 氢给体数：
  0
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  2-苯并唑啉酮 、 亚磷酸二异丙酯 在 4-甲基吡啶 、 copper diacetate 作用下， 以 甲苯 为溶剂， 80.0 ℃ 、101.33 kPa 条件下， 反应 0.67h， 以70%的产率得到diisopropyl(2-oxobenzo[d]oxazol-3(2H)-yl)phosphonate
  参考文献：
  名称：

  Copper-Catalyzed Oxidative Cross-Coupling of H-Phosphonates and Amides to N-Acylphosphoramidates

  摘要：

  A simple combination of copper(II) acetate (Cu(OAc)(2)) and an appropriate base could promote oxidative cross-coupling of H-phosphonates and amides using air as a terminal oxidant. The substrate scope was broad with respect to both dialkyl H-phosphonates and nitrogen nucleophiles (including oxazolidinone, lactam, pyrrolidinone, urea, indole, and sulfonamide derivatives), giving the corresponding P-N coupling products in moderate to high yields.

  DOI：

  10.1021/ol303420g

文献信息

• Copper-Catalyzed Oxidative Cross-Coupling of <i>H</i>-Phosphonates and Amides to <i>N</i>-Acylphosphoramidates
  作者：Xiongjie Jin、Kazuya Yamaguchi、Noritaka Mizuno

  DOI：10.1021/ol303420g

  日期：2013.1.18

  A simple combination of copper(II) acetate (Cu(OAc)(2)) and an appropriate base could promote oxidative cross-coupling of H-phosphonates and amides using air as a terminal oxidant. The substrate scope was broad with respect to both dialkyl H-phosphonates and nitrogen nucleophiles (including oxazolidinone, lactam, pyrrolidinone, urea, indole, and sulfonamide derivatives), giving the corresponding P-N coupling products in moderate to high yields.