2-(哌啶-4-基)吡啶双盐酸盐 | 143924-45-2

• 物质功能分类: 医药中间体 - 吡啶类化合物
• 分子结构分类: 有机化合物 - 有机氮化合物
• 中文名称: 2-(哌啶-4-基)吡啶双盐酸盐
• 中文别名: 2-(哌啶-4-基)吡啶二盐酸盐
• 英文名称: 2-(Piperidin-4-yl)pyridine dihydrochloride
• 英文别名: 2-piperidin-4-ylpyridine;dihydrochloride
• CAS: 143924-45-2
• 化学式: C10H16Cl2N2
• 分子量: 235.15
• InChiKey: NXCFRWODOJQICL-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.39
• 重原子数：
  14
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  24.9
• 氢给体数：
  3
• 氢受体数：
  2

安全信息

• 危险等级：
  IRRITANT
• 海关编码：
  2933990090

文献信息

• [EN] PHENOXY-PYRIDYL DERIVATIVES<br/>[FR] DÉRIVÉS PHÉNOXY-PYRIDYLÉS
  申请人：PFIZER

  公开号：WO2009081259A1

  公开（公告）日：2009-07-02

  Compounds and pharmaceutically acceptable salts of the compounds are disclosed, wherein the compounds have the structure of Formula (I), as defined in the specification. Corresponding pharmaceutical compositions, methods of treatment, methods of synthesis, and intermediates are also disclosed.

  披露了化合物及化合物的药物可接受盐，其中化合物具有本说明书中定义的式(I)的结构。还披露了相应的药物组合物、治疗方法、合成方法和中间体。
• CYCLIC AMINOMETHYL PYRIMIDINE DERIVATIVE
  申请人：SUMITOMO DAINIPPON PHARMA CO., LTD.

  公开号：US20160122319A1

  公开（公告）日：2016-05-05

  The present invention provides a cyclic aminomethyl pyrimidine derivative and a pharmaceutically acceptable salt thereof with high selectivity for dopamine D 4 receptors, which are useful for treating a disease such as attention deficit hyperactivity disorder. Specifically, a compound of formula (1) or a pharmaceutically acceptable salt thereof is provided, wherein n and m are independently 1 or 2; R a is C 1-6 alkyl group, C 3-6 cycloalkyl group, or amino group; R b is hydrogen atom, C 1-6 alkyl group or the like, provided that when R a is amino group, then R b is hydrogen atom; R c1 and R c2 are independently hydrogen atom, or C 1-6 alkyl group; R d1 and R d2 are independently hydrogen atom, fluorine atom or the like; ring Q is an optionally-substituted pyridyl group or an optionally-substituted isoquinolyl group; and the bond having a dashed line is a single or double bond.

  本发明提供了一种对多巴胺D4受体具有高选择性的环状氨基甲基嘧啶衍生物及其药用盐，可用于治疗注意力缺陷多动症等疾病。具体提供了一种公式(1)的化合物或其药用盐，其中n和m独立为1或2；Ra为C1-6烷基、C3-6环烷基或氨基；Rb为氢原子、C1-6烷基等，条件是当Ra为氨基时，Rb为氢原子；Rc1和Rc2独立为氢原子或C1-6烷基；Rd1和Rd2独立为氢原子、氟原子等；环Q为可选取代的吡啶基或可选取代的异喹啉基；且虚线表示的键为单键或双键。
• [EN] TRAF 6 INHIBITORS<br/>[FR] INHIBITEURS DE TRAF 6
  申请人：HELMHOLTZ ZENTRUM MUENCHEN DEUTSCHES FORSCHUNGSZENTRUM GESUNDHEIT & UMWELT GMBH

  公开号：WO2018050286A1

  公开（公告）日：2018-03-22

  The invention relates to compounds which are suitable for the treatment of cancer, an immune disease, Parkinson's disease, Cardiac Hypertrophy or Type-2 diabetes and to pharmaceutical compositions containing such compounds. The invention further relates to a kit of parts comprising such compounds.

  本发明涉及适用于治疗癌症、免疫性疾病、帕金森病、心脏肥大或2型糖尿病的化合物，以及含有这些化合物的药物组合物。该发明还涉及包含这些化合物的配套工具包。
• TRAF 6 inhibitors
  申请人：HELMHOLTZ ZENTRUM MUENCHEN—DEUTSCHES FORSCHUNGSZENTRUM FÜR GESUNDHEIT UND UMWELT (GMBH)

  公开号：US10669278B2

  公开（公告）日：2020-06-02

  The invention relates to compounds which are suitable for the treatment of cancer, an immune disease, Parkinson's disease, Cardiac Hypertrophy or Type-2 diabetes and to pharmaceutical compositions containing such compounds. The invention further relates to a kit of parts comprising such compounds.

  本发明涉及适用于治疗癌症、免疫疾病、帕金森病、心肌肥大或 2 型糖尿病的化合物，以及含有此类化合物的药物组合物。本发明还涉及一种包含此类化合物的部件套件。
• NEW QUINAZOLINE-4-AMINO-2-(PIPERIDINE-1-YL-4-SUBSTITUTED) DERIVATIVES HAVING ANTI-HYPERTENSIVE ACTIVITY, A METHOD FOR THEIR PREPARATION AND THEIR PHARMACEUTICAL USE
  申请人：ROTTA RESEARCH LABORATORIUM S.P.A.

  公开号：EP0892790A1

  公开（公告）日：1999-01-27