2-bromo-3-hydroxy-5,5,8,8-tetra-methyl-5,6,7,8-tetrahydro-naphthalene | 168082-64-2

• 分子结构分类: 有机化合物 - 苯类化合物 - 四氢化萘
• 英文名称: 2-bromo-3-hydroxy-5,5,8,8-tetra-methyl-5,6,7,8-tetrahydro-naphthalene
• 英文别名: 2-bromo-3-hydroxy-5,6,7,8-tetrahydro-5,5,8,8-tetramethylnaphthalene；3-hydroxy-2-bromo-5,5,8,8-tetramethyl-5,6,7,8-tetrahydronaphthalene；3-hydroxy-2-bromo-5,5,8,8-tetrahydro-5,5,8,8-tetramethylnaphtalene；3-Bromo-5,5,8,8-tetramethyl-5,6,7,8-tetrahydro-2-naphthol；3-bromo-2-hydroxy-5,6,7,8-tetrahydro-5,5,8,8-tetramethylnaphthalene；3-bromo-5,5,8,8-tetramethyl-5,6,7,8-tetrahydronaphthalen-2-ol；2-Naphthalenol, 3-bromo-5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-；3-bromo-5,5,8,8-tetramethyl-6,7-dihydronaphthalen-2-ol
• CAS: 168082-64-2
• 化学式: C₁₄H₁₉BrO
• 分子量: 283.208
• InChiKey: YWEGYQWOTPKCMT-UHFFFAOYSA-N

物化性质

• 沸点：
  321.5±42.0 °C(Predicted)
• 密度：
  1.243±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  5.4
• 重原子数：
  16
• 可旋转键数：
  0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.57
• 拓扑面积：
  20.2
• 氢给体数：
  1
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  2-bromo-3-hydroxy-5,5,8,8-tetra-methyl-5,6,7,8-tetrahydro-naphthalene 在 四丁基溴化铵 、 叔丁基锂 、 N,N-二异丙基乙胺 作用下， 以 二氯甲烷 为溶剂， 生成 3-methoxymethoxy-5,5,8,8-tetrahydro-5,5,8,8-tetramethylnaphtalen-2-yl carboxylic acid
  参考文献：
  名称：

  视黄酸受体α亚型特异性激动剂的鉴定。

  摘要：

  DOI：

  10.1021/jm9603532
• 作为产物：
  描述：

  5,5,8,8-四甲基-5,6,7,8-四氢萘-2-醇 在 溴 作用下， 以 溶剂黄146 为溶剂， 生成 2-bromo-3-hydroxy-5,5,8,8-tetra-methyl-5,6,7,8-tetrahydro-naphthalene
  参考文献：
  名称：

  Aryl or heteroaryl amides of tetrahydronaphthalene, chroman, thichroman and 1,2,3,4-tetrahydroquinolinecarboxlic acids, having an electron withdrawing substituent in the aromatic or heteroaromatic moiety, having retinoid-like biological activity

  摘要：

  该式化合物具有类视黄醇生物活性，其中符号的含义在规范中定义。

  公开号：

  US06342602B1

文献信息

• Diarylselenide compounds and their use in human or veterinary medicine and in cosmetics
  申请人：Bernardon Jean-Michel

  公开号：US20060014803A1

  公开（公告）日：2006-01-19

  The invention concerns novel diarylselenide compounds corresponding to formula (I): and the use thereof in pharmaceutical compositions in human or veterinary medicine (in the treatment of dermatological, rheumatic, cardiovascular and ophthalmologic pathologies in particular), or in cosmetic compositions.

  该发明涉及与以下化学式（I）对应的新型二芳基硒化合物，以及其在人类或兽医药物中的使用（特别是在治疗皮肤病、风湿病、心血管病和眼科病变方面），或在化妆品中的使用。
• Propynyl or dienyl biaromatic compounds
  申请人：Centre International de Recherches Dermatologiques Galderma

  公开号：US06046220A1

  公开（公告）日：2000-04-04

  The invention relates to novel propynyl or dienyl biaromatic compounds which have the general formula (I) ##STR1## as well as to the use of these compounds in pharmaceutical compositions intended for use in human or veterinary medicine (dermatological, rheumatic, respiratory, cardiovascular and ophthalmological complaints in particular), or alternatively in cosmetic compositions.

  这项发明涉及具有一般式（I）##STR1##的新型丙炔基或二烯基双芳香化合物，以及这些化合物在用于人类或兽医药物（特别用于皮肤病、风湿病、呼吸系统疾病、心血管疾病和眼科疾病）的制剂中的使用，或者在化妆品制剂中的使用。
• Polyaromatic propynyl compounds and pharmaceutical/cosmetic compositions
  申请人：C.I.R.D. Galderma

  公开号：US05716624A1

  公开（公告）日：1998-02-10

  Novel pharmaceutically/cosmetically-active polyaromatic propynyl compounds have the structural formula (1): ##STR1## in which X is one of the radicals: ##STR2## and are useful for the treatment of a wide variety of disease states, whether human or veterinary, for example dermatological, rheumatic, respiratory, cardiovascular and ophthalmological disorders, as well as for the treatment of mammalian skin and hair conditions/disorders.

  新型具有药用/化妆活性的多芳香丙炔化合物具有结构式（1）：##STR1## 其中X是以下基团之一：##STR2## 并且可用于治疗各种疾病状态，无论是人类还是兽医，例如皮肤病、风湿病、呼吸系统疾病、心血管疾病和眼科疾病，以及哺乳动物皮肤和毛发状况/疾病的治疗。
• Bioactive bicyclic aromatic compounds and pharmaceutical/cosmetic
  申请人：Centre International de Recherches Dermatologiques Galderma

  公开号：US05763487A1

  公开（公告）日：1998-06-09

  Novel pharmaceutically/cosmetically-active bicyclic aromatic compounds have the structural formula (I): ##STR1## and are useful for the treatment of a wide variety of disease states, whether human or veterinary, for example dermatological, rheumatic, respiratory, cardiovascular and ophthalmological disorders, as well as for the treatment of mammalian skin and hair conditions/disorders.

  新型具有药用/化妆活性的双环芳香化合物具有结构式(I)：##STR1##，可用于治疗各种疾病状态，无论是人类还是兽医领域，例如皮肤病、风湿病、呼吸系统疾病、心血管疾病和眼科疾病，以及哺乳动物皮肤和头发状况/疾病的治疗。
• Biphenyl derivatives substituted by an aromatic or heteroaromatic radical and pharamaceutical and cosmetic compositions containing same
  申请人：Galderma Research & Development

  公开号：US06316009B1

  公开（公告）日：2001-11-13

  “Biphenyl derivatives substituted with an aromatic or heteroaromatic radical, and pharmaceutical and cosmetic compositions containing them” in which: Ar represents an aromatic or a heteroaromatic radical optionally substituted, in particular, with an alkyl or a carboxyl group, R2 and R3 represent, in particular, H or alkyl, or R2 and R3, taken together, form a 5- or 6-membered ring, R4 and R5 represent, in particular, H or halogen, R6 represents, in particular, H or lower alkyl, and the salts of the compounds of formula (I). These compounds can be used in particular in the treatment of dermatological complaints associated with a keratinization disorder, and for combating ageing of the skin.

  含有芳香或杂环芳基取代的联苯衍生物，以及含有它们的药用和化妆品组合物，其中：Ar代表一个芳香或杂环芳基，可选地取代，特别是与烷基或羧基取代，R2和R3代表特别是H或烷基，或者R2和R3一起形成一个5-或6-成员环，R4和R5代表特别是H或卤素，R6代表特别是H或较低的烷基，以及具有化合物的盐的化合物。这些化合物可以用于特别是治疗与角化不良有关的皮肤疾病，并用于对抗皮肤衰老。