1-cyclooctylidene-2-(4-(2,4-dichlorophenyl)thiazol-2-yl)hydrazine | 1448514-13-3

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 1-cyclooctylidene-2-(4-(2,4-dichlorophenyl)thiazol-2-yl)hydrazine
• 英文别名: N-(cyclooctylideneamino)-4-(2,4-dichlorophenyl)-1,3-thiazol-2-amine
• CAS: 1448514-13-3
• 化学式: C₁₇H₁₉Cl₂N₃S
• 分子量: 368.33
• InChiKey: PFYQUSFLDGZQEH-UHFFFAOYSA-N

物化性质

• 熔点：
  161-162 °C
• 沸点：
  504.3±58.0 °C(predicted)
• 密度：
  1.37±0.1 g/cm3(Temp: 20 °C; Press: 760 Torr)(predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  6.5
• 重原子数：
  23
• 可旋转键数：
  3
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.41
• 拓扑面积：
  65.5
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  2,4-二氯苯乙酮 在 溴 作用下， 以 乙醇 、 氯仿 为溶剂， 生成 1-cyclooctylidene-2-(4-(2,4-dichlorophenyl)thiazol-2-yl)hydrazine
  参考文献：
  名称：

  Synthesis and cytotoxicity of novel (thiazol-2-yl)hydrazine derivatives as promising anti-Candida agents

  摘要：

  Thirty-eight new (4-(4-substituted-phenyl/2,4-disubstituted-phenyl)-thiazol-2-yl)hydrazine derivatives were synthesized in good yield and assayed for their in vitro anti-Candida activity, compared to topical and systemic antifungal drugs, against twenty-two clinical isolates of Candida spp. The concurrent presence of aliphatic chains or cycloaliphatic rings at N1-hydrazine and a 4-methyl/4-methoxyphenyl at C4 position of the thiazole nucleus exhibited an interesting anti-Candida inhibitory activity. Moreover, some of the most active compounds showed synergistic antifungal effects and lower cell toxicity when combined with clotrimazole. (C) 2013 Elsevier Masson SAS. All rights reserved.

  DOI：

  10.1016/j.ejmech.2013.04.042

文献信息

• Synthesis and cytotoxicity of novel (thiazol-2-yl)hydrazine derivatives as promising anti-Candida agents
  作者：Simone Carradori、Daniela Secci、Adriana Bolasco、Daniela Rivanera、Emanuela Mari、Alessandra Zicari、Lavinia Vittoria Lotti、Bruna Bizzarri

  DOI：10.1016/j.ejmech.2013.04.042

  日期：2013.7

  Thirty-eight new (4-(4-substituted-phenyl/2,4-disubstituted-phenyl)-thiazol-2-yl)hydrazine derivatives were synthesized in good yield and assayed for their in vitro anti-Candida activity, compared to topical and systemic antifungal drugs, against twenty-two clinical isolates of Candida spp. The concurrent presence of aliphatic chains or cycloaliphatic rings at N1-hydrazine and a 4-methyl/4-methoxyphenyl at C4 position of the thiazole nucleus exhibited an interesting anti-Candida inhibitory activity. Moreover, some of the most active compounds showed synergistic antifungal effects and lower cell toxicity when combined with clotrimazole. (C) 2013 Elsevier Masson SAS. All rights reserved.