1,2,3,4-tetrahydro-pyrido[1,2-a]pyrimidin-5-ylium; bromide | 1186216-95-4

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶并嘧啶类
• 英文名称: 1,2,3,4-tetrahydro-pyrido[1,2-a]pyrimidin-5-ylium; bromide
• 英文别名: 3,4-Dihydro-2H-pyrido[1,2-a]pyrimidine--hydrogen bromide (1/1)；3,4-dihydro-2H-pyrido[1,2-a]pyrimidine;hydrobromide
• CAS: 1186216-95-4；1293409-16-1
• 化学式: Br*C₈H₁₁N₂
• 分子量: 215.093
• InChiKey: QIJIQJJOUYATTM-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -2.21
• 重原子数：
  11
• 可旋转键数：
  0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.38
• 拓扑面积：
  15.9
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  3-(2-pyridinylamino)-1-propylbromide hydrobromide 在 N,N-二异丙基乙胺 作用下， 以 二氯甲烷 为溶剂， 反应 1.0h， 生成 1,2,3,4-tetrahydro-pyrido[1,2-a]pyrimidin-5-ylium; bromide
  参考文献：
  名称：

  [EN] PROCESS
  [FR] PROCÉDÉ

  摘要：

  公开号：

  WO2009111679A3

文献信息

• Basic alumina supported one-pot synthesis of structurally diverse pyridine/quinolinine-fused novel diazepanium, diazocanium, imidazodilinium and tetrahydro-pyrimidiniums
  作者：Rupankar Paira、Arindam Maity、Shyamal Mondal、Subhendu Naskar、Krishnendu B. Sahu、Pritam Saha、Abhijit Hazra、E. Padmanaban、Sukdeb Banerjee、Nirup B. Mondal

  DOI：10.1016/j.tetlet.2011.01.134

  日期：2011.4

  Basic alumina supported solvent-free one-pot synthesis of pyridine-fused polycyclic diazepaniums was achieved under microwave irradiation. The process was successfully extended to the synthesis of pyridine-fused bicyclic imidazolidiniums and tetrahydro-pyrimidiniums and also of tri- and tetracyclic diaza-heterocycle-fused quinoliniums. The dual characteristic of basic alumina, a solid support as well as a base, was successfully employed in the current investigation. The method emerged to be an effective route in terms of product yield, reaction time, and ease of purification and most importantly for environment friendly protocols. (c) 2011 Elsevier Ltd. All rights reserved.
• [EN] PROCESS<br/>[FR] PROCÉDÉ
  申请人：GLAXOSMITHKLINE LLC

  公开号：WO2009111679A3

  公开（公告）日：2010-04-22