1-phenyl-2-(3-pyridyl)hydrazine | 17999-52-9

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 1-phenyl-2-(3-pyridyl)hydrazine
• 英文别名: 3-(N'-phenyl-hydrazino)-pyridine；N-phenyl-N'-[3]pyridyl hydrazine；N-Phenyl-N'-[3]pyridyl-hydrazin；1-Phenyl-2-pyridin-3-ylhydrazine
• CAS: 17999-52-9
• 化学式: C₁₁H₁₁N₃
• 分子量: 185.228
• InChiKey: RCYJSCIREHOFRG-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.7
• 重原子数：
  14
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  37
• 氢给体数：
  2
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  phenyl(pyridin-3-yl)diazene 在 乙醚 、 苯基溴化镁 、 苯 作用下， 生成 1-phenyl-2-(3-pyridyl)hydrazine
  参考文献：
  名称：

  Pentimalli; Risaliti, Annali di Chimica, 1956, vol. 46, p. 1037,1046

  摘要：

  DOI：

文献信息

• Pentimalli; Risaliti, Annali di Chimica, 1956, vol. 46, p. 1037,1046
  作者：Pentimalli、Risaliti

  DOI：——

  日期：——
• QUINOLINE DERIVATIVES AS NEUROKININ RECEPTOR ANTAGONISTS
  申请人：MERCK SHARP & DOHME LTD.

  公开号：EP1888530A2

  公开（公告）日：2008-02-20
• [EN] QUINOLINE DERIVATIVES AS NEUROKININ RECEPTOR ANTAGONISTS<br/>[FR] DERIVES DE QUINOLINE UTILISES COMME ANTAGONISTES DU RECEPTEUR DE LA NEUROKININE
  申请人：MERCK SHARP & DOHME

  公开号：WO2006120478A2

  公开（公告）日：2006-11-16

  [EN] The present invention relates to substituted quinoline hydrazides of Formula (I): (CH2) 0-6 -Z- (CHR5V- R2 (I) wherein R1, R2, R3, R4, R5, X, Y and Z are defined herein, pharmaceutical compositions comprising them and their use in treating diseases mediated by neurokinin-2 and/or neurokinin-3 (NK-3) receptors. These compounds can thus be used in methods of treatment to suppress and treat such disorders.
  [FR] La présente invention concerne des hydrazides de quinoline substitués de formule (I) (CH2) 0-6 -Z- (CHR5V- R2), dans laquelle R1, R2, R3, R4, R5, X, Y et Z sont tels que définis dans le mémorandum descriptif. Elle concerne également des compositions pharmaceutiques comprenant ces composés et leur utilisation dans le traitement de maladies induites par les récepteurs de la neurokinine 2 et/ou de la neurokinine 3 (NK3). Ces composés peuvent donc être utilisés dans des méthodes de traitement pour traiter et vaincre ces troubles.
• Reaction of azoarenes with tributyltin hydride
  作者：Angelo Alberti、Nicola Bedogni、Massimo Benaglia、Rino Leardini、Daniele Nanni、Gian Franco Pedulli、Antonio Tundo、Giuseppe Zanardi

  DOI：10.1021/jo00028a038

  日期：1992.1

  Tributyltin hydride when reacted with a series of substituted azoarenes afforded hydrazo compounds with high chemoselectivity and good to high yields. With ortho-substituted azoarenes, mixtures of hydrazo derivatives and N-heterocycles or cyclic products only were obtained. The kinetic law of the process was determined in the presence and in the absence of AIBN; with the radical initiator the reaction proceeds via a radical chain mechanism, whereas without AIBN the presence of stannyl free radicals could be discarded. The mechanism of the noninitiated reaction is discussed. EPR characterization of spin adducts obtained by reacting group IVB organometallic radicals with azo compounds is reported.