2-(benzylthio)-7-methylimidazo[1,2-a]pyrimidin-5(1H)-one | 1208231-61-1

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 咪唑并嘧啶类
• 英文名称: 2-(benzylthio)-7-methylimidazo[1,2-a]pyrimidin-5(1H)-one
• 英文别名: 2-(Benzylthio)-7-methylimidazo[1,2-a]pyrimidin-5(1H)-one；2-benzylsulfanyl-7-methyl-8H-imidazo[1,2-a]pyrimidin-5-one
• CAS: 1208231-61-1
• 化学式: C₁₄H₁₃N₃OS
• 分子量: 271.343
• InChiKey: PPILOZFRXQCHGK-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.8
• 重原子数：
  19
• 可旋转键数：
  3
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.14
• 拓扑面积：
  72.2
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  溴代环戊烷 、 2-(benzylthio)-7-methylimidazo[1,2-a]pyrimidin-5(1H)-one 在 sodium hydride 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 以97%的产率得到2-(benzylthio)-1-cyclopentyl-7-methylimidazo[1,2-a]pyrimidin-5(1H)-one
  参考文献：
  名称：

  Microwave-Assisted Synthesis of Substituted 2-(Benzylthio)imidazo[1,2a]pyrimidin-5-ones

  摘要：

  A microwave-assisted solid-phase synthesis of 2-(benzylthio)imidazo[1,2a]pyrimidin-5-ones has been developed. Using microwave irradiation, the reaction time was significantly reduced from a few days to 80 min. A representative set of 10 2-(benzylthio)-6.7-substituted-imidazo[1,2a]pyrimidin-5-ones was prepared. These compounds Were subsequently N-alkylated and formylated in good yields.

  DOI：

  10.1021/cc900176x

文献信息

• Microwave-Assisted Synthesis of Substituted 2-(Benzylthio)imidazo[1,2<i>a</i>]pyrimidin-5-ones
  作者：Chai Hoon Soh、Yulin Lam

  DOI：10.1021/cc900176x

  日期：2010.3.8

  A microwave-assisted solid-phase synthesis of 2-(benzylthio)imidazo[1,2a]pyrimidin-5-ones has been developed. Using microwave irradiation, the reaction time was significantly reduced from a few days to 80 min. A representative set of 10 2-(benzylthio)-6.7-substituted-imidazo[1,2a]pyrimidin-5-ones was prepared. These compounds Were subsequently N-alkylated and formylated in good yields.