N,N-diethyl-2,3-difluoro-6-methylfuro[2,3-b]pyrazine-7-carboxamide | 1227065-15-7

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 呋喃
• 英文名称: N,N-diethyl-2,3-difluoro-6-methylfuro[2,3-b]pyrazine-7-carboxamide
• CAS: 1227065-15-7
• 化学式: C₁₂H₁₃F₂N₃O₂
• 分子量: 269.251
• InChiKey: HFWMBIJXLIUQJT-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.1
• 重原子数：
  19
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.42
• 拓扑面积：
  59.2
• 氢给体数：
  0
• 氢受体数：
  6

反应信息

• 作为反应物：
  描述：

  N,N-diethyl-2,3-difluoro-6-methylfuro[2,3-b]pyrazine-7-carboxamide 、 二乙胺 以 乙腈 为溶剂， 反应 24.0h， 以95%的产率得到3-(diethylamino)-N,N-diethyl-2-fluoro-6-methylfuro[2,3-b]pyrazine-7-carboxamide
  参考文献：
  名称：

  Annelation of perfluorinated heteroaromatic systems by 1,3-dicarbonyl derivatives

  摘要：

  Reactions of various perfluorinated heteroaromatic substrates such as tetrafluoro-4-cyanopyridine, tetrafluoropyrazine and tetrafluoropyridazine with 1,3-dicarbonyl systems gave corresponding [5,6]-ring fused furo derivatives. Subsequent reactions of the [5,6] bicyclic scaffolds with nucleophiles gave some highly functionalised heteroaromatic systems. (C) 2010 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tet.2010.02.083
• 作为产物：
  描述：

  四氟吡嗪 、 N,N-二乙基乙酰乙酰胺 在 sodium hydride 作用下， 以 四氢呋喃 、 mineral oil 为溶剂， 反应 26.0h， 以60%的产率得到N,N-diethyl-2,3-difluoro-6-methylfuro[2,3-b]pyrazine-7-carboxamide
  参考文献：
  名称：

  Annelation of perfluorinated heteroaromatic systems by 1,3-dicarbonyl derivatives

  摘要：

  Reactions of various perfluorinated heteroaromatic substrates such as tetrafluoro-4-cyanopyridine, tetrafluoropyrazine and tetrafluoropyridazine with 1,3-dicarbonyl systems gave corresponding [5,6]-ring fused furo derivatives. Subsequent reactions of the [5,6] bicyclic scaffolds with nucleophiles gave some highly functionalised heteroaromatic systems. (C) 2010 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tet.2010.02.083

文献信息

• Annelation of perfluorinated heteroaromatic systems by 1,3-dicarbonyl derivatives
  作者：Matthew W. Cartwright、Emma L. Parks、Graham Pattison、Rachel Slater、Graham Sandford、Ian Wilson、Dmitrii S. Yufit、Judith A.K. Howard、John A. Christopher、David D. Miller

  DOI：10.1016/j.tet.2010.02.083

  日期：2010.4

  Reactions of various perfluorinated heteroaromatic substrates such as tetrafluoro-4-cyanopyridine, tetrafluoropyrazine and tetrafluoropyridazine with 1,3-dicarbonyl systems gave corresponding [5,6]-ring fused furo derivatives. Subsequent reactions of the [5,6] bicyclic scaffolds with nucleophiles gave some highly functionalised heteroaromatic systems. (C) 2010 Elsevier Ltd. All rights reserved.