申请人:Waters Technologies Corporation
公开号:US10092894B2
公开(公告)日:2018-10-09
The present disclosure relates to a method of separating a compound of interest, particularly unsaturated compound(s) of interest, from a mixture. The compound is separated using a column having a chromatographic stationary phase material for various different modes of chromatography containing a first substituent and a second substituent. The first substituent minimizes compound retention variation over time under chromatographic conditions. The second substituent chromatographically and selectively retains the compound by incorporating one or more aromatic, polyaromatic, heterocyclic aromatic, or polyheterocyclic aromatic hydrocarbon groups, each group being optionally substituted with an aliphatic group.
本公开涉及一种从混合物中分离相关化合物,特别是相关不饱和化合物的方法。使用色谱柱分离化合物,该色谱柱具有用于各种不同色谱模式的色谱固定相材料,其中含有第一取代基和第二取代基。在色谱条件下,第一取代基可最大程度地减少化合物保留时间的变化。第二取代基通过加入一个或多个芳香族、多芳香族、杂环芳香族或多杂环芳香族烃基团(每个基团可选择被脂肪族基团取代),在色谱上选择性地保留化合物。