3-(5-(1,3-dioxolan-2-yl)furan-2-yl)phenol | 1276045-85-2

• 分子结构分类: 有机化合物 - 苯类化合物 - 酚类
• 英文名称: 3-(5-(1,3-dioxolan-2-yl)furan-2-yl)phenol
• 英文别名: 3-[5-(1,3-Dioxolan-2-yl)furan-2-yl]phenol；3-[5-(1,3-dioxolan-2-yl)furan-2-yl]phenol
• CAS: 1276045-85-2
• 化学式: C₁₃H₁₂O₄
• 分子量: 232.236
• InChiKey: ACJTZGJXMFCWFR-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.7
• 重原子数：
  17
• 可旋转键数：
  2
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.23
• 拓扑面积：
  51.8
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  3-碘苯酚 、 5-(1,3-dioxolan-2-yl)-2-furanylzinc bromide 在 2-双环己基膦-2',6'-二甲氧基联苯 、 palladium diacetate 作用下， 以 四氢呋喃 为溶剂， 反应 0.5h， 以72%的产率得到3-(5-(1,3-dioxolan-2-yl)furan-2-yl)phenol
  参考文献：
  名称：

  5-(1,3-Dioxolan-2-yl)-2-furanylzinc bromide; direct preparation, and its application for the synthesis of 5-substituted furan derivatives

  摘要：

  5-(1,3-Dioxolan-2-yl)-2-furanylzinc bromide was easily prepared by the direct insertion of active zinc to 2-bromo-5-(1,3-dioxolane)furan under mild conditions. Of interest, the resulting organozinc was successfully coupled with aryl halides and acid chlorides affording the corresponding coupling products in good to excellent yields. (C) 2011 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2011.01.006

文献信息

• 5-(1,3-Dioxolan-2-yl)-2-furanylzinc bromide; direct preparation, and its application for the synthesis of 5-substituted furan derivatives
  作者：Reuben D. Rieke、Seung-Hoi Kim

  DOI：10.1016/j.tetlet.2011.01.006

  日期：2011.3

  5-(1,3-Dioxolan-2-yl)-2-furanylzinc bromide was easily prepared by the direct insertion of active zinc to 2-bromo-5-(1,3-dioxolane)furan under mild conditions. Of interest, the resulting organozinc was successfully coupled with aryl halides and acid chlorides affording the corresponding coupling products in good to excellent yields. (C) 2011 Elsevier Ltd. All rights reserved.