4-hydroxy-4'-vinylbiphenyl | 93249-93-5

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 4-hydroxy-4'-vinylbiphenyl
• 英文别名: [1,1'-Biphenyl]-4-ol, 4'-ethenyl-；4-(4-ethenylphenyl)phenol
• CAS: 93249-93-5
• 化学式: C₁₄H₁₂O
• 分子量: 196.249
• InChiKey: BWZNAPOWXNNKME-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4
• 重原子数：
  15
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  20.2
• 氢给体数：
  1
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  4-hydroxy-4'-vinylbiphenyl 生成 4-acetoxy-4'-vinylbiphenyl
  参考文献：
  名称：

  TANIGAKI, TEIICHI

  摘要：

  DOI：
• 作为产物：
  描述：

  4-(α-Hydroxyethyl)-4'-hydroxy-1,1'-biphenyl 生成 4-hydroxy-4'-vinylbiphenyl
  参考文献：
  名称：

  TANIGAKI, TEIICHI

  摘要：

  DOI：

文献信息

• [EN] SUBSTITUTED 3- AND 4- AMINOMETHYLPIPERIDINES FOR USE AS BETA-SECRETASE IN THE TREATMENT OF ALZHEIMER'S DISEASE<br/>[FR] 3- ET 4- AMINOMETHYLPIPERIDINES SUBSTITUEES UTILISEES COMME BETA-SECRETASE DANS LE TRAITEMENT DE LA MALADIE D'ALZHEIMER
  申请人：ACTELION PHARMACEUTICALS LTD

  公开号：WO2004002483A1

  公开（公告）日：2004-01-08

  The invention relates to novel compounds, which are substituted chiral or achiral derivatives of 3- or 4- aminomethylpiperidine of the general formula (I). The invention also concerns related aspects including processes for the preparation of the compounds, pharmaceutical compositions containing one or more compounds of general formula (I) and especially their use as inhibitors of beta-secretases for the treatment of Alzheimer’s disease.

  本发明涉及新型化合物，其为通式（I）的3-或4-氨基甲基哌啶的取代手性或非手性衍生物。本发明还涉及包括制备这些化合物的工艺、含有一种或多种通式（I）化合物的药物组合物以及特别是它们作为β-分泌酶抑制剂用于治疗阿尔茨海默病的相关方面。
• New Hybrid Inorganic−Organic Polymers as Supports for Heterogeneous Catalysis:  A Novel Pd(0) Metalated Cyclophosphazene-Containing Polymer as an Efficient Heterogeneous Catalyst for the Heck Reaction
  作者：Vadapalli Chandrasekhar、Arunachalampillai Athimoolam

  DOI：10.1021/ol026098z

  日期：2002.6.1

  [reaction: see text] A new Pd(0) complex of a pendant cyclophosphazene-containing cross-linked polymer is found to be an effective heterogeneous catalyst for the Heck arylation reaction. The catalyst is robust and can be recycled without significant loss of activity.

  [反应：见正文]发现一种新的含环磷腈侧基交联聚合物的Pd（0）络合物是用于Heck芳基化反应的有效多相催化剂。该催化剂是坚固的，可以循环使用而没有明显的活性损失。
• Synthesis of biaryl-styrene monomers by microwave-assisted Suzuki coupling
  作者：Hazit A. Zayas、Michael C. Bowyer、Christopher P. Gordon、Clovia I. Holdsworth、Adam McCluskey

  DOI：10.1016/j.tetlet.2009.07.117

  日期：2009.10

  Biaryl-styrenic monomers are prepared via Suzuki coupling as functional monomers in the synthesis of molecularly imprinted polymers. Traditional thermal Suzuki approaches are hampered by competition between Suzuki, Heck and homo-coupling reactions. Microwave-assisted approaches facilitated rapid access to the desired Suzuki products whilst suppressing both Heck and homo-couplings of 4-vinylboronic

  联芳基苯乙烯单体是通过Suzuki偶联制备的，作为分子印迹聚合物合成中的功能单体。铃木，赫克和均偶联反应之间的竞争阻碍了传统的热铃木方法。微波辅助方法有助于快速获得所需的铃木产品，同时抑制4-乙烯基硼酸的Heck和均偶联。
• Metalated hybrid polymers as catalytic reagents for phosphate ester hydrolysis and plasmid modification
  作者：Vadapalli Chandrasekhar、Pravas Deria、Venkatasubbaiah Krishnan、Arunachalampillai Athimoolam、Sanjay Singh、C. Madhavaiah、S.G. Srivatsan、Sandeep Verma

  DOI：10.1016/j.bmcl.2003.12.082

  日期：2004.3

  cross-linked polymer (CPPL) has been utilized for binding Zn(II). The metalated polymer (CPPL-Zn) has been found to be very effective catalyst for the hydrolysis of a RNA model phosphodiester substrate [2-(hydroxypropyl)-p-nitrophenyl phosphate, hNPP]. In addition, CPPL-Zn also cleaved supercoiled plasmid DNA pBR322 thus providing a novel structural motif of inorganic-organic hybrid polymers as synthetic

  侧链含吡唑基环磷腈的杂化交联聚合物（CPPL）已用于结合Zn（II）。已经发现金属化的聚合物（CPPL-Zn）是用于水解RNA模型磷酸二酯底物[2-（羟丙基）-对硝基苯基磷酸酯，hNPP]的非常有效的催化剂。另外，CPPL-Zn还切割超螺旋质粒DNA pBR322，从而提供了无机-有机杂化聚合物作为合成核酸酶的新型结构基序。
• Pd-catalyzed protecting-group-free cross-couplings of iodophenols with atom-economic triarylbismuth reagents
  作者：Maddali L.N. Rao、Suresh Meka

  DOI：10.1016/j.tetlet.2019.151512

  日期：2020.2

  An efficient protocol for the protecting-group-free synthesis of unsymmetrical hydroxybiaryls via the Pd-catalyzed cross-couplings of unprotected iodophenols with triarylbismuth reagents is described. The presented protocols exhibits good to high yields of hydroxybiaryls.

  描述了通过未保护的碘代苯酚与三芳基铋试剂的Pd催化的交叉偶联来无保护地合成不对称羟基联芳基的有效方案。提出的协议表现出良好的羟基联芳基的高收率。