2-(3-fluorophenyl)-1-(4-methoxyphenyl)ethan-1-one | 153529-18-1

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 二苯乙烯类
• 英文名称: 2-(3-fluorophenyl)-1-(4-methoxyphenyl)ethan-1-one
• 英文别名: 2-(3-Fluoro-phenyl)-1-(4-methoxy-phenyl)-ethanone；2-(3-Fluorophenyl)-1-(4-methoxyphenyl)ethanone
• CAS: 153529-18-1
• 化学式: C₁₅H₁₃FO₂
• mdl: MFCD11545169
• 分子量: 244.265
• InChiKey: PGKAVRBAZXUZIY-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.3
• 重原子数：
  18
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.133
• 拓扑面积：
  26.3
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  2-(3-fluorophenyl)-1-(4-methoxyphenyl)ethan-1-one 在 lithium aluminium tetrahydride 作用下， 以 四氢呋喃 为溶剂， 反应 5.5h， 以100%的产率得到2-(3-Fluoro-phenyl)-1-(4-methoxy-phenyl)-ethanol
  参考文献：
  名称：

  Antifungal agents. 5. Chloro and amino derivatives of 1,2-diaryl-1-(1H-imidazol-1-yl)ethane with potent antifungal activities

  摘要：

  Various derivatives of 1,2-diaryl-1-(1H-imidazol-1-yl)ethane have been synthesized and tested against Candida albicans and Candida spp. In vitro essays showed chloro and amino derivatives to be as active as miconazole and bifonazole and more potent than ketoconazole. Structure-activity relationships of the new imidazole antifungal agents are discussed.

  DOI：

  10.1016/0223-5234(93)90031-9
• 作为产物：
  描述：

  1-(3-fluorophenyl)-2-(4-methoxyphenyl)ethane-1,2-dione 在 三乙胺 、 亚磷酸三乙酯 、 10-甲基-9-均三甲苯基吖啶高氯酸盐 作用下， 以 乙腈 为溶剂， 以63 %的产率得到2-(3-fluorophenyl)-1-(4-methoxyphenyl)ethan-1-one
  参考文献：
  名称：

  可见光催化下 α-二酮与亚磷酸酯的区域选择性加氢脱氧

  摘要：

  通过可见光光氧化还原催化，以亚磷酸酯为脱氧试剂实现了α-二酮的新型区域选择性加氢脱氧。获得了较宽的底物范围和较高的官能团兼容性。不对称的α-二酮在较高亲电性的羰基处被选择性还原。与现有方法相比，这种独特的区域选择性使其成为α-二酮单氢脱氧的实用补充方法。

  DOI：

  10.1021/acs.orglett.3c02936

文献信息

• Antifungal agents. 5. Chloro and amino derivatives of 1,2-diaryl-1-(1H-imidazol-1-yl)ethane with potent antifungal activities
  作者：M Artico、S Massa、R Di Santo、R Costi、A Retico、G Apuzzo、N Simonetti

  DOI：10.1016/0223-5234(93)90031-9

  日期：1993.1

  Various derivatives of 1,2-diaryl-1-(1H-imidazol-1-yl)ethane have been synthesized and tested against Candida albicans and Candida spp. In vitro essays showed chloro and amino derivatives to be as active as miconazole and bifonazole and more potent than ketoconazole. Structure-activity relationships of the new imidazole antifungal agents are discussed.
• Regioselective Hydrodeoxygenation of α-Diketones with Phosphites under Visible-Light Catalysis
  作者：Hui Yang、Yan Li、Wenhui Zhang、Jiayan Song、Jingyu Hu、Mengya Wang、Han Yao、Xia Xu、Na Li、Yanbo Yang、Rongrong Yu、Shuxia Xie、Cuiying Ye、Guo Wei

  DOI：10.1021/acs.orglett.3c02936

  日期：2023.10.13

  Novel regioselective hydrodeoxygenation of α-diketones with phosphites as the deoxygenation reagent was realized via visible-light photoredox catalysis. Broad substrate scope and high functional group compatibility were obtained. Unsymmetric α-diketones were selectively reduced at the carbonyls of higher electrophilicity. This unique regioselectivity compared with available methods makes it a practical

  通过可见光光氧化还原催化，以亚磷酸酯为脱氧试剂实现了α-二酮的新型区域选择性加氢脱氧。获得了较宽的底物范围和较高的官能团兼容性。不对称的α-二酮在较高亲电性的羰基处被选择性还原。与现有方法相比，这种独特的区域选择性使其成为α-二酮单氢脱氧的实用补充方法。