Diaminostilben | 24949-07-3

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 二苯乙烯类
• 英文名称: Diaminostilben
• 英文别名: 3-[2-(3-Aminophenyl)ethenyl]aniline
• CAS: 24949-07-3
• 化学式: C₁₄H₁₄N₂
• 分子量: 210.279
• InChiKey: DAYCGUFRTLWJCZ-UHFFFAOYSA-N

物化性质

• 沸点：
  441.0±34.0 °C(Predicted)
• 密度：
  1.186±0.06 g/cm3(Temp: 20 °C; Press: 760 Torr)(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2.8
• 重原子数：
  16
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  52
• 氢给体数：
  2
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  Diaminostilben 、 methyl thiophene-2-carbimidothioate hydroiodide 以 乙醇 为溶剂， 反应 36.0h， 以46%的产率得到
  参考文献：
  名称：

  用于治疗黑色素瘤的神经元一氧化氮合酶的强效选择性双头噻吩-2-羧酰亚胺抑制剂

  摘要：

  神经元一氧化氮合酶 (nNOS) 的选择性抑制剂被认为是具有治疗慢性神经退行性疾病和人类黑色素瘤治疗潜力的有价值和强大的药物。在这里，我们描述了一种新的混合策略，它将药代动力学上有前景的 thiophene-2-carboximidamide 片段和我们之前报道的有效和选择性氨基吡啶抑制剂的结构特征相结合。两种抑制剂，13和14，显示出低纳摩尔抑制效力 ( K i= 5 nM for nNOS）和良好的异构体选择性（nNOS 超过 eNOS [分别为 440 和 540 倍]和超过 iNOS [分别为 260 和 340 倍]）。这些 nNOS 抑制剂复合物的晶体结构揭示了一个新的热点，它解释了14的选择性以及为什么将仲胺转化为叔胺会导致选择性增强。更重要的是，这些化合物是第一种在黑色素瘤细胞系中表现出优异体外功效的高效选择性 nNOS 抑制剂。

  DOI：

  10.1021/jm401252e
• 作为产物：
  描述：

  3-硝基溴苄 在 hydrazine hydrate 、 lithium hexamethyldisilazane 作用下， 以 四氢呋喃 、 甲醇 、 甲苯 为溶剂， 反应 17.5h， 生成 Diaminostilben
  参考文献：
  名称：

  用于治疗黑色素瘤的神经元一氧化氮合酶的强效选择性双头噻吩-2-羧酰亚胺抑制剂

  摘要：

  神经元一氧化氮合酶 (nNOS) 的选择性抑制剂被认为是具有治疗慢性神经退行性疾病和人类黑色素瘤治疗潜力的有价值和强大的药物。在这里，我们描述了一种新的混合策略，它将药代动力学上有前景的 thiophene-2-carboximidamide 片段和我们之前报道的有效和选择性氨基吡啶抑制剂的结构特征相结合。两种抑制剂，13和14，显示出低纳摩尔抑制效力 ( K i= 5 nM for nNOS）和良好的异构体选择性（nNOS 超过 eNOS [分别为 440 和 540 倍]和超过 iNOS [分别为 260 和 340 倍]）。这些 nNOS 抑制剂复合物的晶体结构揭示了一个新的热点，它解释了14的选择性以及为什么将仲胺转化为叔胺会导致选择性增强。更重要的是，这些化合物是第一种在黑色素瘤细胞系中表现出优异体外功效的高效选择性 nNOS 抑制剂。

  DOI：

  10.1021/jm401252e

文献信息

• Novel bis[1,6-dihydro-6,6-dimethyl-1,3,5-triazine-2,4-diamines] as antitrypanosomal agents
  作者：William R. Turner、Leslie M. Werbel

  DOI：10.1021/jm00149a032

  日期：1985.11

  A series of novel 1,1'-(4,1-phenylene)bis [1,6-dihydro-6,6-dimethyl-1,3,5-triazine-2,4-diamines] was prepared and evaluated for activity against Trypanosoma rhodesiense in mice. The importance of the bis structure and the nature of the spacer between the two phenyl rings for optimal activity have been revealed. The potent parenteral activity of several analogues within this series as well as preliminary indication of oral activity lends encouragement to further development of this structural class.
• LIQUID CRYSTAL ALIGNMENT AGENT, LIQUID CRYSTAL ALIGNMENT FILM, AND LIQUID CRYSTAL DISPLAY DEVICE
  申请人：Chi Mei Corporation

  公开号：US20150275092A1

  公开（公告）日：2015-10-01

  A liquid crystal alignment agent, a liquid crystal alignment film, and a liquid crystal display device are provided. The liquid crystal alignment agent includes a polymer composition (A-1) and a solvent (B). The polymer composition (A-1) is obtained by reacting a tetracarboxylic acid dianhydride compound (a) with a diamine compound (b). The diamine compound (b) includes at least one type of diamine (b-1) represented by formula (I) and at least one type of diamine (b-2) having the structure represented by formula (II). The liquid crystal alignment agent can be made into a liquid crystal display device having good uniformity of pretilt angle after ultraviolet irradiation.
• LIQUID CRYSTAL ALIGNMENT AGENT, LIQUID CRYSTAL ALIGNMENT FILM, AND LIQUID CRYSTAL DISPLAY ELEMENT HAVING THE SAME
  申请人：CHI MEI CORPORATION

  公开号：US20170029703A1

  公开（公告）日：2017-02-02

  The present invention relates to a liquid crystal alignment agent, a liquid crystal alignment film and a liquid crystal display element. The liquid crystal alignment agent includes a polymer composition (A) synthesized by tetracarboxylic dianhydride compound (a) and diamine compound (b), and a solvent (B). The diamine compound (b) includes diamine (b-1) shown as following formula (I) and diamine (b-2): in formula (I), R 1 represents a linear or branched alkyl of 1 to 6 carbons, a linear or branched hydroxyl alkyl of 1 to 6 carbons, an alkoxy of 1 to 6 carbons, an alkylthio of 1 to 6 carbons, a halogen atom, an amino group or a nitro group; R 2 represents a methylene group, a divalent alkyl of 2 to 10 carbons, a divalent alkenyl of 2 to 7 carbons or a divalent alkynyl of 2 to 6 carbons; and a represents an integer of 0 to 3.
• LIQUID CRYSTAL POLYMERIZED FILMS USING ALIGNMENT FILM AND POLYMERIZABLE LIQUID CRYSTAL COMPOSTION
  申请人：JNC CORPORATION

  公开号：US20180163135A1

  公开（公告）日：2018-06-14

  Liquid crystal polymerization films, prepared by applying a polymerizable liquid crystal composition containing a polymerizable liquid crystal compound represented by formula (2) on an alignment film prepared by calcinating a composition containing a polymer represented by a repeating unit of formula (1), and subsequently polymerizing the polymerizable liquid crystal composition. In formula (1), R 1 is independently a tetravalent group, R 2 is independently a divalent functional group and R 3 is independently a hydrogen atom or a monovalent functional group. PG 1 -Sp 1 -R 4 -Sp 2 -PG 2 (2) In formula (2), R 4 represents a divalent group formed by combining five or more and nine or less of alicycles and/or aromatic rings, SP 1 and SP 2 represent a spacer group, and PG 1 and PG 2 represents an alkyl group, an alkoxyl group, a cyano group, fluorine or a polymerizable functional group, in which either group is the polymerizable functional group.
• US9505981B2
  申请人：——

  公开号：US9505981B2

  公开（公告）日：2016-11-29