tribenzyl-methyl-ammonium; hydroxide | 20812-67-3

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: tribenzyl-methyl-ammonium; hydroxide
• 英文别名: Tribenzyl-methyl-ammonium; Hydroxid；Tribenzyl(methyl)azanium;hydroxide
• CAS: 20812-67-3
• 化学式: C₂₂H₂₄N*HO
• 分子量: 319.447
• InChiKey: GSTFRTMWAWKAGF-UHFFFAOYSA-M

计算性质

• 辛醇/水分配系数(LogP)：
  4.86
• 重原子数：
  24
• 可旋转键数：
  6
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.18
• 拓扑面积：
  1
• 氢给体数：
  1
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  tribenzyl-methyl-ammonium; hydroxide 生成 三苄胺
  参考文献：
  名称：

  Marquardt, Chemische Berichte, 1886, vol. 19, p. 1027

  摘要：

  DOI：
• 作为产物：
  描述：

  alkaline earth salt of/the/ methylsulfuric acid 在 AgO₂ 作用下， 生成 tribenzyl-methyl-ammonium; hydroxide
  参考文献：
  名称：

  Marquardt, Chemische Berichte, 1886, vol. 19, p. 1027

  摘要：

  DOI：

文献信息

• Sulfonyl aryl or heteroaryl hydroxamic acid compounds
  申请人：G. D. Searle & Co.,

  公开号：US20030191317A1

  公开（公告）日：2003-10-09

  A sulfonyl aromatic or heteroaromatic ring hydroxamic acid compound that inter alia inhibits matrix metalloprotease activity is disclosed as are a treatment process that comprises administering a contemplated sulfonyl aromatic or heteroaromatic ring hydroxamic acid compound in a MMP enzyme-inhibiting effective amount to a host having a condition associated with pathological matrix metalloprotease activity.

  本发明涉及一种磺酰基芳香或杂芳环羟羧酸化合物，该化合物在抑制基质金属蛋白酶活性方面起作用，还涉及一种治疗方法，包括向与病理性基质金属蛋白酶活性相关病情的宿主投入考虑的磺酰基芳香或杂芳环羟羧酸化合物，其有效量抑制MMP酶活性。
• Use of sulfonyl aryl or heteroaryl hydroxamic acids and derivatives thereof as aggrecanase inhibitors
  申请人：——

  公开号：US20030171404A1

  公开（公告）日：2003-09-11

  This invention is directed to a process for inhibiting aggrecanase activity. The process comprises administering a therapeutically effective amount of a sulfonyl aromatic or heteroaromatic hydroxamic acid, a derivative thereof, or a pharmaceutically acceptable salt of the hydroxamic acid or derivative to a host animal. The compound generally corresponds in structure to the following formula: 1 wherein W and the R groups are described in more detail in Applicants' specification.

  这项发明涉及一种抑制聚集素酶活性的过程。该过程包括向宿主动物施用一定治疗有效量的磺酰芳香或杂芳羟肟酸、其衍生物或羟肟酸或其衍生物的药用盐。该化合物通常与以下结构对应：1其中W和R基的详细描述在申请人的说明书中。
• Sulfonyl aryl hydroxamates and their use as matrix metalloprotease inhibitors
  申请人：——

  公开号：US20030073845A1

  公开（公告）日：2003-04-17

  This invention is directed to sulfonyl aromatic hydroxamic acid compounds and salts thereof that, inter alia, inhibit matrix metalloprotease (MMP) activity and/or aggrecanase activity. In some particularly preferred embodiments, the compound corresponds in structure to one of the following formulas: 1 wherein W 2 , the R groups, and —A—R—E—Y are described in more detail in Applicants' specification. This invention also is directed to a process that comprises administering such a compound or pharmaceutically acceptable salt thereof to a host animal having a condition associated with MMP activity.

  本发明涉及磺酰基芳基羟肟酸化合物及其盐，这些化合物在抑制基质金属蛋白酶（MMP）活性和/或聚集素酶活性方面具有作用。在一些特别优选的实施方式中，该化合物的结构符合以下公式之一：其中W2、R基团和—A—R—E—Y在申请人的说明书中有更详细的描述。本发明还涉及一种过程，该过程包括向患有与MMP活性相关的病况的宿主动物施用这种化合物或其药用可接受盐。
• [EN] THIOL SULFONE METALLOPROTEASE INHIBITORS<br/>[FR] COMPOSES A BASE DE SULFONE DE THIOL SERVANT D'INHIBITEURS DES METALLOPROTEASES
  申请人：MONSANTO COMPANY

  公开号：WO1998003164A1

  公开（公告）日：1998-01-29

  (EN) This invention is directed to proteinase (protease) inhibitors, and more particularly to thiol sulfone inhibitors for matrix metalloproteinase 13(MMP-13), compositions of proteinase inhibitors, intermediates for the syntheses of proteinase inhibitors, processes for the preparation of proteinase inhibitors and processes for treating pathological conditions associated with pathological matrix metalloproteinase activity related to MMP-13.(FR) Cette invention se rapporte à des inhibiteurs de protéinases (protéases) et plus particulièrement à des inhibiteurs à base de sulfone de thiol pour les métalloprotéases matricielles 13 (MMP-13), à des compositions d'inhibiteurs de protéinases, à des intermédiaires pour la synthèse d'inhibiteurs de protéinases, à des procédés pour la préparation d'inhibiteurs de protéinases et à des procédés pour traiter les états pathologiques associés à une activité pathologique des métalloprotéases matricielles du type MMP-13.

  该发明涉及蛋白酶（蛋白酶）抑制剂，更具体地涉及硫醇磺酰抑制剂用于基质金属蛋白酶13（MMP-13），蛋白酶抑制剂组合物，蛋白酶抑制剂合成的中间体，制备蛋白酶抑制剂的过程以及用于治疗与MMP-13相关的病理基质金属蛋白酶活性相关的病理状态的过程。
• [EN] AROMATIC SULFONE HYDROXAMIC ACID METALLOPROTEASE INHIBITOR<br/>[FR] INHIBITEUR DE METALLOPROTEASE A BASE D'ACIDE HYDROXAMIQUE AROMATIQUE SULFONÉ
  申请人：SEARLE & CO

  公开号：WO2000050396A1

  公开（公告）日：2000-08-31

  A treatment process is disclosed that comprises administering an effective amount of an aromatic sulfone hydroxamic acid that exhibits excellent inhibitory activity of one or more matrix metalloprotease (MMP) enzymes, such as MMP-2, MMP-9 and MMP-13, while exhibiting substantially less inhibition at least of MMP-1 to a host having a condition associated with pathological matrix metalloprotease activity. Also disclosed are metalloprotease inhibitor compounds having those selective activities, processes for manufacture of such compounds and pharmaceutical compositions using an inhibitor.

  本发明公开了一种治疗过程，包括向患有与病理性基质金属蛋白酶活性相关的疾病的宿主施用一种具有出色抑制活性的芳香基磺酮羟肟酸的有效量，例如MMP-2、MMP-9和MMP-13，同时对至少MMP-1的抑制作用明显较小。此外，还公开了具有这些选择性活性的金属蛋白酶抑制剂化合物，制造这种化合物的过程以及使用抑制剂的制药组合物。