4-isopropyl-N-phenylbenzamide | 15088-90-1

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 4-isopropyl-N-phenylbenzamide
• 英文别名: 4-isopropyl-benzoic acid anilide；4-Isopropyl-benzoesaeure-anilid；Cuminsaeure-anilid；(4-Isoropyl-benzoesaeure)-anilid；N-Phenyl-4-isopropyl-benzamid；N-phenyl-4-propan-2-ylbenzamide
• CAS: 15088-90-1
• 化学式: C₁₆H₁₇NO
• mdl: MFCD01352166
• 分子量: 239.317
• InChiKey: RQOGGEIIARVSOU-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.7
• 重原子数：
  18
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.187
• 拓扑面积：
  29.1
• 氢给体数：
  1
• 氢受体数：
  1

反应信息

• 作为产物：
  描述：

  4-异丙基二苯甲酮 在 sodium hydroxide 、 乙醇 、 五氯化磷 、 盐酸羟胺 、 水 作用下， 生成 4-isopropyl-N-phenylbenzamide
  参考文献：
  名称：

  Smith, Chemische Berichte, 1891, vol. 24, p. 4047

  摘要：

  DOI：

文献信息

• Aerobic oxidative transformation of primary alcohols and amines to amides promoted by a hydroxyapatite-supported gold catalyst in water
  作者：Wentao Wang、Yu Cong、Leilei Zhang、Yanqiang Huang、Xiaodong Wang、Tao Zhang

  DOI：10.1016/j.tetlet.2013.10.133

  日期：2014.1

  In the presence of an easily prepared hydroxyapatite-supported gold catalyst, namely Au/HAP, various kinds of structurally diverse primary alcohols including benzylic and aliphatic ones, and amines involving aromatic and secondary ones could be converted into the corresponding amides in water with up to 99% yield. Meanwhile, on the basis of experimental observations and literatures, a plausible reaction

  在易于制备的羟基磷灰石负载的金催化剂（即Au / HAP）的存在下，水中最多可将各种结构不同的伯醇（包括苄基和脂族醇）以及涉及芳族和仲醇的胺转化为相应的酰胺。产率99％。同时，在实验观察和文献的基础上，描述了合理的反应途径以阐明反应机理。
• NaF regulated aqueous phase synthesis of aromatic amides and imines catalyzed by Au/HT
  作者：Qianqian Wang、Youquan Deng、Feng Shi

  DOI：10.1039/c4cy00210e

  日期：——

  An Au/HT catalyst was found to be an efficient heterogeneous catalyst for the coupling reaction of aromatic alcohols and amines.

  一种Au/HT催化剂被发现是芳香醇和胺的偶联反应的高效杂化催化剂。
• FUSED IMIDAZOLE DERIVATIVE HAVING TTK INHIBITORY ACTION
  申请人：Kusakabe Ken-ichi

  公开号：US20120059162A1

  公开（公告）日：2012-03-08

  Provided are a compound represented by general formula (1) and having a TTK inhibitory action and a medicine containing the compound. In formula (1), (X, Y, V, W) is (—N═, ═CR 1 —, ═N—, —CR 7 ═), (—CR 2 ═, ═N—, ═N—, —CR 7 ═), etc.; A is an (un)substituted aromatic hydrocarbon ring, etc.; L is a single bond, —C(═O)—NR A —, etc.; Z is a group represented by the formula —NR 3 R 4 or a group represented by the formula —OR 5 ; R 1 to R 3 , R 6 , and R 7 each is a hydrogen atom, etc.; R 4 and R 5 each is an (un)substituted alkyl, etc.; and R 8 is an (un)substituted cycloalkyl, etc.

  提供了一个由一般式（1）表示的化合物，具有TTK抑制作用，以及含有该化合物的药物。在式（1）中，（X，Y，V，W）为（—N═，═CR1—，═N—，—CR7═），（—CR2═，═N—，═N—，—CR7═），等等；A为（非）取代芳香烃环等；L为一个单键，—C(═O)—NRA—等；Z为由式—NR3R4或式—OR5表示的基团；R1至R3，R6和R7分别是氢原子等；R4和R5分别是（非）取代烷基等；R8是（非）取代环烷基等。
• Synthesis of Secondary Amides through the Palladium(II)-Catalyzed Aminocarbonylation of Arylboronic Acids with Amines or Hydrazines and Carbon Monoxide
  作者：Jin Zhang、Yuqiang Ma、Yangmin Ma

  DOI：10.1002/ejoc.201701802

  日期：2018.4.17

  A new Pd‐catalyzed aminocarbonylation of arylboronic acids with amines or hydrazines produces secondary amides. The method exhibits good atom‐economy and a wide functional group tolerance.

  芳族硼酸与胺或肼的新Pd催化氨基羰基化反应会生成仲酰胺。该方法具有良好的原子经济性和宽泛的官能团耐受性。
• BENZAMIDE DERIVATIVES AND THEIR USE FOR TREATING CNS DISORDERS
  申请人：Galley Guido

  公开号：US20090036420A1

  公开（公告）日：2009-02-05

  The present invention relates to methods of treating CNS disorders with a compound of formula I wherein X, R 1 , R 2 , R 3 , R 4 , R 5 , R 6 , R 7 , and R 8 are as defined in the specification and pharmaceutically acceptable acid addition salts thereof.

  本发明涉及使用式I中的化合物治疗中枢神经系统疾病的方法，其中X、R1、R2、R3、R4、R5、R6、R7和R8如说明书中所定义，并且包括药学上可接受的酸盐。