Kresyl-methansulfinat | 40644-11-9

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: Kresyl-methansulfinat
• 英文别名: p-Tolyl methylsulfinate；(4-methylphenyl) methanesulfinate
• CAS: 40644-11-9；64826-08-0
• 化学式: C₈H₁₀O₂S
• 分子量: 170.232
• InChiKey: XQLQIINSLZVYAY-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.7
• 重原子数：
  11
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.25
• 拓扑面积：
  45.5
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  对甲酚 、 甲烷亚磺酰氯化物 在 吡啶 作用下， 生成 Kresyl-methansulfinat
  参考文献：
  名称：

  Nucleophilic substitution at sulfur. Effect of nucleophile and leaving group basicity as probe of bond formation and breaking

  摘要：

  DOI：

  10.1021/ja00790a031

文献信息

• The Mechanism of the Reactions of Alkoxy- and Aryloxytrimethylsilanes with Sulfinyl Chlorides. A Doubt about 4-Center Mechanism for the Bimolecular IVb–VIb Bond Cleavages
  作者：Seizi Kozuka、Tetsuji Higashino

  DOI：10.1246/bcsj.54.1183

  日期：1981.4

  Kinetic studies have been conducted for the reactions of ethoxytrimethylsilane with benzenesulfinyl chloride and aryloxytrimethylsilane with methanesulfinyl chloride. Both the reactions were found to obey second order rate equation. A clear negative ρ value was observed for the reaction of aryloxytrimethylsilane. The solvent effects suggested that both the two reactions were quite similar in their mechanisms. Nucleophilic addition of silyloxygen atom to sulfinyl group has been suggested for these two reactions.

  对乙氧基三甲基硅烷与苯亚磺酰氯及芳氧基三甲基硅烷与甲基亚磺酰氯的反应进行了动力学研究。这两类反应均遵循二级速率方程。在芳氧基三甲基硅烷的反应中观察到了一个明显的负ρ值.溶剂效应表明这两个反应的机理颇为相似。人们提出这两个反应的机理是硅氧原子对亚磺酰基的亲核加成。
• [EN] SHP2 PHOSPHATASE INHIBITORS AND METHODS OF USE THEREOF<br/>[FR] INHIBITEURS DE LA PROTÉINE SHP2 PHOSPHATASE ET LEURS PROCÉDÉS D'UTILISATION
  申请人：RELAY THERAPEUTICS INC

  公开号：WO2019165073A1

  公开（公告）日：2019-08-29

  The present disclosure relates to novel compounds and pharmaceutical compositions thereof, and methods for inhibiting the activity of SHP2 phosphatase with the compounds and compositions of the disclosure. The present disclosure further relates to, but is not limited to, methods for treating disorders associated with SHP2 deregulation with the compounds and compositions of the disclosure.

  本公开涉及新颖化合物及其药物组合物，以及利用本公开的化合物和组合物抑制SHP2磷酸酶活性的方法。本公开还涉及但不限于利用本公开的化合物和组合物治疗与SHP2失调相关的疾病的方法。
• A kinetic study for the reaction of aryloxytrimethylsilane with methanesulfinyl chloride giving aryl methanesulfinate
  作者：Seizi Kozuka、Tetsuji Higashino

  DOI：10.1016/s0040-4039(00)71488-2

  日期：1980.1

  A nucleophilic attack of phenoxy-oxygen has been suggested as the mechanism of the reaction of aryloxytrimethylsilane with methanesulfinyl chloride.

  已经提出苯氧-氧的亲核攻击是芳氧基三甲基硅烷与甲亚磺酰氯反应的机理。
• NOVEL MODULATORS OF CALCIUM RELEASE-ACTIVATED CALCIUM CHANNEL
  申请人：Rhizen Pharmaceuticals SA

  公开号：US20150166526A1

  公开（公告）日：2015-06-18

  Disclosed are novel calcium release-activated calcium (CRAC) channel inhibitors, methods for preparing them, pharmaceutical compositions containing them, and methods of treatment using them. The present disclosure also relates to methods for treating non-small cell lung cancer (NSCLC) with CRAC inhibitors, and to methods for identifying therapeutics for treating and of diagnosing cancer.

  本文揭示了一种新的钙释放激活钙（CRAC）通道抑制剂，制备它们的方法，含有它们的药物组合物，以及使用它们的治疗方法。本文还涉及使用CRAC抑制剂治疗非小细胞肺癌（NSCLC）的方法，以及识别用于治疗和诊断癌症的治疗剂和诊断方法。
• US9758514B2
  申请人：——

  公开号：US9758514B2

  公开（公告）日：2017-09-12