2,4-dihydroxy-6-methyl-benzophenone | 43221-40-5

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2,4-dihydroxy-6-methyl-benzophenone
• 英文别名: 2,4-Dihydroxy-6-methyl-benzophenon；2,4-Dihydroxy-6-methylbenzophenon；2-Benzoyl-3,5-dihydroxytoluol；(2,4-Dihydroxy-6-methylphenyl)(phenyl)methanone；(2,4-dihydroxy-6-methylphenyl)-phenylmethanone
• CAS: 43221-40-5
• 化学式: C₁₄H₁₂O₃
• 分子量: 228.247
• InChiKey: GZRGXWUQQWWYQX-UHFFFAOYSA-N

物化性质

• 熔点：
  145–146°C
• 沸点：
  381.8±11.0 °C(Predicted)
• 密度：
  1.263±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  3.5
• 重原子数：
  17
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.07
• 拓扑面积：
  57.5
• 氢给体数：
  2
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  2,4-dihydroxy-6-methyl-benzophenone 、 苯甲酰氯 在 吡啶 作用下， 生成 2,4-bis-benzoyloxy-6-methyl-benzophenone
  参考文献：
  名称：

  �ber die Kondensation von Benzoin und Orcin

  摘要：

  DOI：

  10.1007/bf01512882
• 作为产物：
  描述：

  N-苯基亚胺苄基氯 在 盐酸 、 三氯化铝 、 乙醚 作用下， 生成 2,4-dihydroxy-6-methyl-benzophenone
  参考文献：
  名称：

  Phadke; Shah, Journal of the Indian Chemical Society, 1950, vol. 27, p. 349,353

  摘要：

  DOI：

文献信息

• Curvularin. Part VII. Some acylations of 3,5-dihydroxytoluene and its dimethyl ether
  作者：H. D. Munro、O. C. Musgrave、Richard Templeton

  DOI：10.1039/j39710000095

  日期：——

  3,5-Dihydroxytoluene is acylated in the 2-position by octanoyl chloride in the presence of aluminium chloride. In polyphosphoric acid it reacts with 7-oxo-octanoic acid and with crotonic acid to give the corresponding 4-acyl derivative and 7-hydroxy-2,5-dimethylchroman-4-one respectively. Under the same conditions 3,5-dimethoxytoluene and crotonic acid give the dioxobenzodipyran (V). Tin(IV) chloride

  在氯化铝的存在下，通过辛酰氯将3，5-二羟基甲苯酰化在2-位上。在多磷酸中，它与7-氧代辛酸和巴豆酸反应，分别得到相应的4-酰基衍生物和7-羟基-2,5-二甲基苯并吡喃-4-酮。在相同条件下3，5-二甲氧基甲苯和巴豆酸得到二氧苯并双吡喃（V）。氯化锡（IV）通过2位的巴豆酰氯和2位和6位的苯甲酰氯对3,5-二甲氧基甲苯的酰化作用。
• Hoesch, Chemische Berichte, 1915, vol. 48, p. 1125
  作者：Hoesch

  DOI：——

  日期：——
• Desai; Vakil, Proceedings - Indian Academy of Sciences, Section A, 1940, vol. 12, p. 391,394
  作者：Desai、Vakil

  DOI：——

  日期：——
• XANTHONE-RICH PLANT EXTRACTS OR COMPOUNDS THEREFROM FOR MODULATING DISEASES OF THE CENTRAL NERVOUS SYSTEM AND RELATED DISORDERS
  申请人：Deakin University

  公开号：US20160367521A1

  公开（公告）日：2016-12-22

  The invention relates to a method of treatment and/or prophylaxis of a disease or disorder of the central nervous system comprising administering to a mammal in need thereof an effective amount of a xanthone-rich plant extract, or a compound derived from a xanthone-rich plant extract. The invention also relates to use of a xanthone-rich plant extract, or a compound derived from a xanthone-rich plant extract, in the preparation of a medicament for the treatment and/or prophylaxis of a disease or disorder of the central nervous system and to a xanthone-rich plant extract, or a compound derived from a xanthone-rich plant extract, for use in the treatment and/or prophylaxis of a disease or disorder of the central nervous system.
• Phadke; Shah, Journal of the Indian Chemical Society, 1950, vol. 27, p. 349,353
  作者：Phadke、Shah

  DOI：——

  日期：——