2-[(2,6-二甲基苯基)氨基]-N,N,N-三甲基-2-氧代乙烷氯化铵 | 21236-55-5

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 中文名称: 2-[(2,6-二甲基苯基)氨基]-N,N,N-三甲基-2-氧代乙烷氯化铵
• 英文名称: Ammonium
• 英文别名: QX-222；2-[(2,6-Dimethylphenyl)amino]-n,n,n-trimethyl-2-oxoethanaminium；[2-(2,6-dimethylanilino)-2-oxoethyl]-trimethylazanium
• CAS: 21236-55-5
• 化学式: C₁₃H₂₁N₂O
• 分子量: 221.323
• InChiKey: QYUXPWDVDMSTKR-UHFFFAOYSA-O

物化性质

• 溶解度：
  可溶于水中

计算性质

• 辛醇/水分配系数(LogP)：
  1.4
• 重原子数：
  16
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.46
• 拓扑面积：
  29.1
• 氢给体数：
  1
• 氢受体数：
  1

安全信息

• 安全说明：
  S22,S24/25
• 海关编码：
  2924299090

文献信息

• Capture compounds, collections thereof and methods for analyzing the proteome and complex compositions
  申请人：Kõster Hubert

  公开号：US20100248264A1

  公开（公告）日：2010-09-30

  Capture compounds and collections thereof and methods using the compounds for the analysis of biomolecules are provided. In particular, collections, compounds and methods are provided for analyzing complex protein mixtures, such as the proteome. The compounds are multifunctional reagents that provide for the separation and isolation of complex protein mixtures. Automated systems for performing the methods also are provided.

  提供了捕获化合物及其集合以及使用这些化合物进行生物分子分析的方法。特别地，提供了用于分析复杂蛋白质混合物（如蛋白质组）的集合、化合物和方法。这些化合物是多功能试剂，可用于分离和分离复杂的蛋白质混合物。还提供了执行这些方法的自动化系统。
• Compositions for treating pain and pruritus
  申请人：President and Fellows of Harvard College

  公开号：EP2425858A2

  公开（公告）日：2012-03-07

  The invention features a method for inhibiting one or more voltage-gated ion channels in a cell by contacting the cell with (i) a first compound that activates a channel-forming receptor that is present on nociceptors and/or pruriceptors; and (ii) a second compound that inhibits one or more voltage-gated ion channels when applied to the internal face of the channels but does not substantially inhibit said channels when applied to the external face of the channels, wherein the second compound is capable of entering nociceptors or pruriceptors through the channel-forming receptor when the receptor is activated. The invention also features a quarternary amine derivative or other permanently or transiently charged derivative of a compound that inhibits one or more voltage-gated ion channels when applied to the internal face of the channels but does not substantially inhibit said channels when applied to the external face of the channels.

  本发明的特征是一种抑制细胞中一个或多个电压门控离子通道的方法，其方法是将细胞与(i) 第一种化合物接触，该化合物可激活存在于痛觉感受器和/或瘙痒感受器上的通道形成受体；和(ii)第二种化合物，它在作用于通道的内面时抑制一个或多个电压门控离子通道，但在作用于通道的外面时并不实质上抑制所述通道，其中第二种化合物在受体被激活时能够通过通道形成受体进入痛觉感受器或刺痛感受器。本发明还有一种季胺衍生物或其他永久或瞬时带电的化合物衍生物，当作用于一个或多个电压门控离子通道的内部面时，可抑制该通道，但作用于通道的外部面时，不会对上述通道产生实质性的抑制作用。
• Methods, compositions, and kits for treating pain and pruritis
  申请人：President and Fellows of Harvard College

  公开号：EP2446903A2

  公开（公告）日：2012-05-02

  The invention features a method for inhibiting one or more voltage-gated ion channels in a cell by contacting the cell with (i) a first compound that activates a channel-forming receptor that is present on nociceptors and/or pruriceptors; and (ii) a second compound that inhibits one or more voltage-gated ion channels when applied to the internal face of the channels but does not substantially inhibit said channels when applied to the external face of the channels, wherein the second compound is capable of entering nociceptors or pruriceptors through the channel-forming receptor when the receptor is activated. The invention also features a quarternary amine derivative or other permanently or transiently charged derivative of a compound that inhibits one or more voltage-gated ion channels when applied to the internal face of the channels but does not substantially inhibit said channels when applied to the external face of the channels.

  本发明的特征是一种抑制细胞中一个或多个电压门控离子通道的方法，其方法是将细胞与(i) 第一种化合物接触，该化合物可激活存在于痛觉感受器和/或瘙痒感受器上的通道形成受体；和(ii)第二种化合物，它在作用于通道的内面时抑制一个或多个电压门控离子通道，但在作用于通道的外面时并不实质上抑制所述通道，其中第二种化合物在受体被激活时能够通过通道形成受体进入痛觉感受器或刺痛感受器。本发明还有一种季胺衍生物或其他永久或瞬时带电的化合物衍生物，当作用于一个或多个电压门控离子通道的内部面时，可抑制该通道，但作用于通道的外部面时，不会对上述通道产生实质性的抑制作用。
• Permanently charged sodium and calcium channel blockers as anti-inflammatory agents
  申请人：Children's Medical Center Corporation

  公开号：US10729664B2

  公开（公告）日：2020-08-04

  The invention provides compounds, compositions, methods, and kits for the treatment of neurogenic inflammation.

  本发明提供了用于治疗神经源性炎症的化合物、组合物、方法和试剂盒。
• Compositions and methods for pain relief without numbness
  申请人：Abrahmsohn Glenn

  公开号：US11116789B2

  公开（公告）日：2021-09-14

  Methods for providing post-operative pain control or relief, without a medically significant degree of numbness, to a patient are disclosed. Methods include, for example, administering bicarbonate and a calcium salt to an area of a patient during a surgical or dental procedure, near completion of a surgical or dental procedure or immediately following a surgical or dental procedure, in an area previously administered or containing a regional or local anesthetic, in an amount sufficient to provide the patient with pain control or relief, without a medically significant degree of numbness, for a period of time after the surgical or dental procedure.

  本发明公开了为病人提供术后疼痛控制或缓解的方法，但没有医学上明显的麻木程度。这些方法包括，例如，在外科或牙科手术过程中，在外科或牙科手术即将结束时，或在外科或牙科手术结束后，在先前施用或含有区域或局部麻醉剂的部位立即施用碳酸氢盐和钙盐，其用量足以在外科或牙科手术后的一段时间内为患者提供疼痛控制或缓解，而不会产生医学上明显的麻木感。