N-(2-mercaptophenyl)urea | 73266-40-7

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: N-(2-mercaptophenyl)urea
• 英文别名: o-Mercaptophenylharnstoff；2-Mercapto-phenylharnstoff；(2-mercapto-phenyl)-urea；N-(2-Sulfanylphenyl)urea；(2-sulfanylphenyl)urea
• CAS: 73266-40-7
• 化学式: C₇H₈N₂OS
• 分子量: 168.219
• InChiKey: CFZAFRWTQQPEDX-UHFFFAOYSA-N

物化性质

• 熔点：
  152-154 °C
• 沸点：
  289.4±23.0 °C(Predicted)
• 密度：
  1.375±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  0.8
• 重原子数：
  11
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  56.1
• 氢给体数：
  3
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  N-(2-mercaptophenyl)urea 在 溴 作用下， 以 苯 为溶剂， 生成 2-(5-chloro-4-p-tolyl-oxazol-2-ylamino)-benzenethiol
  参考文献：
  名称：

  Nath,J.P. et al., Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry, 1979, vol. 18, p. 384 - 386

  摘要：

  DOI：

文献信息

• 一种抗菌增效剂及其制法和用途
  申请人：上海医药工业研究院

  公开号：CN107629022A

  公开（公告）日：2018-01-26

  本发明涉及一种抗菌增效剂及其制法和用途。具体地，本发明公开了式(I)所示的具有抗菌增效活性的化合物或其光学异构体、顺反异构体或医药学上可接受的盐，及其制备方法。本发明还公开了包含上述化合物的医用组合物及其用途。上述化合物可有效增强多粘菌素B对鲍曼不动杆菌与肺炎克雷伯菌的抗菌活性，并可应用于对多粘菌素不敏感或抑菌活性不强的病菌的抗菌治疗。
• UREA-CONTAINING SILANES, PROCESS FOR PREPARATION THEREOF AND USE THEREOF
  申请人：Evonik Industries AG

  公开号：US20150329571A1

  公开（公告）日：2015-11-19

  The invention relates to urea-containing silanes of the formula I which are prepared by, in a first step, reacting an aminosilane of the formula II with an isocyanate of the formula III and, in a second step, reacting the product from the first process step with sodium sulphide of the formula IV Na 2 S  (IV) or in a first step, reacting an isocyanatosilane of the formula VI with an amine of the formula VII and, in a second step, reacting the product from the first process step with sodium sulphide of the formula IV Na 2 S  (IV).

  该发明涉及公式I的含尿素硅烷，其通过以下步骤制备：第一步，将公式II的氨基硅烷与公式III的异氰酸酯反应，第二步，将第一步的产物与公式IVNa2S的硫化钠反应；或者第一步，将公式VI的异氰酸硅烷与公式VII的胺反应，第二步，将第一步的产物与公式IVNa2S的硫化钠反应。
• PROCESS FOR PREPARING UREA-CONTAINING SILANES
  申请人：Evonik Industries AG

  公开号：US20150329574A1

  公开（公告）日：2015-11-19

  The invention relates to a process for preparing urea-containing silanes of the general formula I wherein a diamine of the general formula II H 2 N—R—S—S—R—NH 2 (II) is reacted with isocyanatosilane of the general formula III (R 1 ) 3 Si—R—NCO  (III) in water.

  该发明涉及一种制备通式I中含尿素硅烷的方法，其中通式II的二胺H2N—R—S—S—R—NH2与通式III的异氰酸硅烷(R1)3Si—R—NCO在水中发生反应。
• Process for the preparation of 2-aminophenyl thioethers
  申请人：Hoechst Aktiengesellschaft

  公开号：US04808752A1

  公开（公告）日：1989-02-28

  A process for the preparation of 2-aminophenyl thioethers of the formula (1) ##STR1## in which R represents an alkylC.sub.1 -C.sub.6 group which can be substituted by hydroxyl, alkoxyC.sub.1 -C.sub.4, carboxyl, --COO-alkyl-C.sub.1 -C.sub.4, alkenylC.sub.2 -C.sub.6 or phenyl groups or by the radical ##STR2## and X and Y are each a hydrogen or halogen atom or an alkylC.sub.1 -C.sub.6, alkoxyC.sub.1 -C.sub.6 or nitro group, wherein the salts of the formula (4) ##STR3## in which X and Y have the stated meanings and Me denotes an alkali metal atom or the equivalent amount of an alkaline earth metal atom, which are obtainable in a known manner by reacting 2-aminobenzothiazoles of the formula (3) ##STR4## in which X and Y have the stated meanings, with an alkali metal or alkaline earth metal hydroxides in an alkali-stable anhydrous or virtually anhydrous solvent are reacted, in the isolated form or, advantageously in suspension in the mixture obtained in the ring-opening step, with an alkylating agent of the formula (2) R-Z (2) in which R has the stated meaning and Z represents a halogen atom, or of the formula (2a) (R'O).sub.2 SO.sub.2 (2 a) in which R' denotes an alkylC.sub.1 -C.sub.4 group, or of the formula (2b) Z--alkyleneC.sub.2 -C.sub.6 Z (2b) in which Z has the stated meaning, or with an alkylene-C.sub.2 -C.sub.3 oxide at 0.degree. to 100.degree. C.

  一种制备式（1）的2-氨基苯基硫醚的方法，其中R代表可以被羟基，烷氧基C.sub.1-C.sub.4，羧基，--COO-烷基C.sub.1-C.sub.4，烯丙基C.sub.2-C.sub.6或苯基或基团##STR2##替代的烷基C.sub.1-C.sub.6。X和Y分别是氢或卤素原子或烷基C.sub.1-C.sub.6，烷氧基C.sub.1-C.sub.6或硝基的基团。其中式（4）的盐##STR3##其中X和Y具有上述含义，Me表示碱金属原子或等量的碱土金属原子，可通过已知方法在碱稳定的无水或几乎无水溶剂中，通过将式（3）的2-氨基苯并噻唑反应物##STR4##其中X和Y具有上述含义，与碱金属或碱土金属氢氧化物反应得到，以分离形式或优选地在开环步骤中获得的混合物悬浮液中，与式（2）的烷基化试剂R-Z（2）反应，其中R具有上述含义，Z代表卤素原子，或式（2a）（R'O）.sub.2SO.sub.2（2a）中的式，其中R'表示烷基C.sub.1-C.sub.4，或式（2b）中的Z-烷基C.sub.2-C.sub.6-Z（2b），其中Z具有上述含义，或在0℃至100℃下与烷基C.sub.2-C.sub.3氧化物反应。
• Process for the preparation of 2-substituted benzothiazoles
  申请人：Hoechst Aktiengesellschaft

  公开号：US04727154A1

  公开（公告）日：1988-02-23

  Process for the preparation of benzothiazoles of the formula (1) ##STR1## wherein R denotes an alkyl.sub.C.sbsb.1.sub.-C.sbsb.6 or an a kenyl.sub.C.sbsb.2.sub.-C.sbsb.6 group which can be substituted by alkoxy.sub.C.sbsb.1.sub.-C.sbsb.4, acyl, phenyl, chlorophenyl, bromophenyl, alkyl.sub.C.sbsb.1.sub.-C.sbsb.4 phenyl, alkoxy.sub.C.sbsb.1.sub.-C.sbsb.4 -phenyl or nitrophenyl groups or halogen atoms, or denotes a phenyl group which can be substituted by alkyl.sub.C.sbsb.1.sub.-C.sbsb.4, alkoxy.sub.C.sbsb.1.sub.-C.sbsb.4, carboxyl-, --COO-alkyl.sub.C.sbsb.1.sub.-C.sub.4, cyano or nitro or halogen atoms, and X and Y each denote a hydrogen or halogen atom or an alkyl.sub.C.sbsb.1.sub.-C.sbsb.4, alkoxy.sub.C.sbsb.1.sub.-C.sbsb.4 or nitro group, or together denote a fused benzene ring, wherein the salts of the corresponding 2-mercaptophenylureas of the formula (5) ##STR2## in which X and Y have the stated meansings and Me denotes an alkali metal atom or the equivalent amount of an alkaline earth metal atom, which salts are obtainable as intermediate compounds in a known manner by reacting 2-aminobenzothiazoles of the general formula (4) ##STR3## in which X and Y have the abovementioned meanings, with alkali metal or alkaline earth metal hydroxides in an anhydrous or virtually anhydrous solvent, are treated, in the isolated form or in suspension in the ring-opening mixture, with an acylating agent of the formula (3) R--CO--Z (3) in which R has the abovementioned meaning and Z represents a halogen atom or the group ##STR4## wherein R has the stated meaning, or with diketene at temperatures from 0.degree. C. to 200.degree. C.

  制备式为(1)的苯并噻唑的过程如下：其中R表示C1-C6的烷基或C2-C6的烯基，可被C1-C4的烷氧基、酰基、苯基、氯苯基、溴苯基、C1-C4的烷基苯基、C1-C4的烷氧基苯基或硝基苯基或卤原子取代；或表示可被C1-C4的烷基、C1-C4的烷氧基、羧基、--COO-C1-C4的烷基、氰基或硝基或卤原子取代的苯基。X和Y分别表示氢或卤原子或C1-C4的烷基、C1-C4的烷氧基或硝基；或者在一起表示融合的苯环。其中，式为(5)的相应2-巯基苯基脲的盐，其中X和Y具有上述含义，Me表示碱金属原子或等量的碱土金属原子，这些盐可以通过已知方法通过在无水或几乎无水溶剂中用碱金属或碱土金属氢氧化物与一般式(4)中X和Y具有上述含义的2-氨基苯并噻唑反应而得到，这些盐在隔离形式或在环开放混合物中悬浮，用式为(3)的酰化剂R-CO-Z(3)或二酮在0℃至200℃的温度下处理，其中R具有上述含义，Z表示卤原子或基团-CH2-COOR，其中R具有所述含义。