2-[(2-甲氧基乙基)氨基]烟酸 | 460363-33-1

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 中文名称: 2-[(2-甲氧基乙基)氨基]烟酸
• 英文名称: 2-[(2-Methoxyethyl)amino]nicotinic acid
• 英文别名: 2-(2-methoxyethylamino)pyridine-3-carboxylic acid
• CAS: 460363-33-1
• 化学式: C₉H₁₂N₂O₃
• mdl: MFCD03114315
• 分子量: 196.206
• InChiKey: VTHFDVOFWPIYPB-UHFFFAOYSA-N

物化性质

• 沸点：
  388.0±37.0 °C(Predicted)
• 密度：
  1.273±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  1.1
• 重原子数：
  14
• 可旋转键数：
  5
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.333
• 拓扑面积：
  71.4
• 氢给体数：
  2
• 氢受体数：
  5

安全信息

• 海关编码：
  2933399090

反应信息

• 作为产物：
  描述：

  2-氯烟酸 、 2-甲氧基乙胺 在 N,N-二异丙基乙胺 作用下， 以 水 为溶剂， 反应 2.0h， 以52%的产率得到2-[(2-甲氧基乙基)氨基]烟酸
  参考文献：
  名称：

  Microwave-assisted synthesis of 2-aminonicotinic acids by reacting 2-chloronicotinic acid with amines

  摘要：

  2-(Methylamino)nicotinic acid was readily prepared in high yield by reacting 2-chloronicotinic acid with 40% aq MeNH2 under microwave irradiation either at 120 degrees for 2 h or at 140 degrees C for 1.5 h. Subsequently, we found that a range of 2-aminonicotinic acids could be obtained under microwave heating. The optimal reaction conditions involved the use of 3 equiv of amine, water as the solvent and heating at 200 degrees C for 2 h in the presence of diisopropylethylamine (3 equiv). (C) 2009 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2009.03.034

文献信息

• Microwave-assisted synthesis of 2-aminonicotinic acids by reacting 2-chloronicotinic acid with amines
  作者：Camilo E. Quevedo、Vassilios Bavetsias、Edward McDonald

  DOI：10.1016/j.tetlet.2009.03.034

  日期：2009.5

  2-(Methylamino)nicotinic acid was readily prepared in high yield by reacting 2-chloronicotinic acid with 40% aq MeNH2 under microwave irradiation either at 120 degrees for 2 h or at 140 degrees C for 1.5 h. Subsequently, we found that a range of 2-aminonicotinic acids could be obtained under microwave heating. The optimal reaction conditions involved the use of 3 equiv of amine, water as the solvent and heating at 200 degrees C for 2 h in the presence of diisopropylethylamine (3 equiv). (C) 2009 Elsevier Ltd. All rights reserved.