2-[(2-甲氧基苯基)甲基]萘 | 68299-62-7

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 中文名称: 2-[(2-甲氧基苯基)甲基]萘
• 英文名称: 2-(2-methoxybenzyl)naphthalene
• 英文别名: 2-[(2-Methoxyphenyl)methyl]naphthalene
• CAS: 68299-62-7
• 化学式: C₁₈H₁₆O
• 分子量: 248.324
• InChiKey: XRCVJFQIPJSMPS-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.1
• 重原子数：
  19
• 可旋转键数：
  3
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.11
• 拓扑面积：
  9.2
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  2-[(2-甲氧基苯基)甲基]萘 在 三溴化硼 作用下， 以 二氯甲烷 为溶剂， 以91%的产率得到2-((naphthalen-2-yl)methyl)phenol
  参考文献：
  名称：

  4,4′-Unsymmetrically substituted 3,3′-biphenyl alpha helical proteomimetics as potential coactivator binding inhibitors

  摘要：

  A series of unsymmetrically substituted biphenyl compounds was designed as alpha helical proteomimetics with the aim of inhibiting the binding of coactivator proteins to the nuclear hormone receptor coactivator binding domain. These compounds were synthesized in good overall yields in seven steps starting from 2-bromoanisole. The final products were evaluated using cotransfection reporter gene assays and mammalian two-hybrid competitive inhibition assays to demonstrate their effectiveness as competitive binding inhibitors. The results from this study indicate that these proteomimetics possess the ability to inhibit coactivator-receptor interactions, but via a mixed mode of inhibition. (C) 2013 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmc.2013.10.051
• 作为产物：
  描述：

  2-萘甲醛 在 三乙基硅烷 、 碘 、 碳酸氢钠 、 magnesium 、 三氟乙酸 作用下， 以 四氢呋喃 、 二氯甲烷 为溶剂， 反应 7.17h， 生成 2-[(2-甲氧基苯基)甲基]萘
  参考文献：
  名称：

  4,4′-Unsymmetrically substituted 3,3′-biphenyl alpha helical proteomimetics as potential coactivator binding inhibitors

  摘要：

  A series of unsymmetrically substituted biphenyl compounds was designed as alpha helical proteomimetics with the aim of inhibiting the binding of coactivator proteins to the nuclear hormone receptor coactivator binding domain. These compounds were synthesized in good overall yields in seven steps starting from 2-bromoanisole. The final products were evaluated using cotransfection reporter gene assays and mammalian two-hybrid competitive inhibition assays to demonstrate their effectiveness as competitive binding inhibitors. The results from this study indicate that these proteomimetics possess the ability to inhibit coactivator-receptor interactions, but via a mixed mode of inhibition. (C) 2013 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmc.2013.10.051

文献信息

• Selective Conversion of Benzylic Phosphates into Diarylmethanes Through Al(OTf)₃ -Catalyzed Friedel-Crafts-Type Benzylation
  作者：Taiga Yurino、Asuka Hachiya、Keisuke Suzuki、Takeshi Ohkuma

  DOI：10.1002/ejoc.202000077

  日期：2020.4.23

  Al(OTf)3 exhibits superior catalyst performance in the Friedel–Crafts‐type benzylation using benzylic phosphate as an electrophile. The reaction can be conducted even with 0.2 mol‐% of the catalyst. Twenty‐one different diarylmethanes are formed. The chemoselective property of the catalyst toward the phosphate group over acetate and bromide is noteworthy.

  Al（OTf）3在使用磷酸苄基酯作为亲电试剂的Friedel-Crafts型苄基化反应中表现出优异的催化剂性能。即使使用0.2 mol％的催化剂也可以进行反应。形成二十一种不同的二芳基甲烷。值得注意的是，催化剂对乙酸根和溴离子的磷酸根的化学选择性。
• 4,4′-Unsymmetrically substituted 3,3′-biphenyl alpha helical proteomimetics as potential coactivator binding inhibitors
  作者：Patrick T. Weiser、Ching-Yi Chang、Donald P. McDonnell、Robert N. Hanson

  DOI：10.1016/j.bmc.2013.10.051

  日期：2014.1

  A series of unsymmetrically substituted biphenyl compounds was designed as alpha helical proteomimetics with the aim of inhibiting the binding of coactivator proteins to the nuclear hormone receptor coactivator binding domain. These compounds were synthesized in good overall yields in seven steps starting from 2-bromoanisole. The final products were evaluated using cotransfection reporter gene assays and mammalian two-hybrid competitive inhibition assays to demonstrate their effectiveness as competitive binding inhibitors. The results from this study indicate that these proteomimetics possess the ability to inhibit coactivator-receptor interactions, but via a mixed mode of inhibition. (C) 2013 Elsevier Ltd. All rights reserved.