2-[(3-氟苄基)氧基]-3-甲氧基苯甲醛 | 588696-81-5

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 中文名称: 2-[(3-氟苄基)氧基]-3-甲氧基苯甲醛
• 英文名称: 2-(3-Fluoro-benzyloxy)-3-methoxy-benzaldehyde
• 英文别名: 2-[(3-fluorophenyl)methoxy]-3-methoxybenzaldehyde
• CAS: 588696-81-5
• 化学式: C₁₅H₁₃FO₃
• mdl: MFCD03422407
• 分子量: 260.26
• InChiKey: DIFKYPAPARPUJR-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.9
• 重原子数：
  19
• 可旋转键数：
  5
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.133
• 拓扑面积：
  35.5
• 氢给体数：
  0
• 氢受体数：
  4

安全信息

• 危险等级：
  IRRITANT
• 危险品标志：
  Xi

文献信息

• FUSED PYRIMIDINEONE COMPOUNDS AS TRPV3 MODULATORS
  申请人：Lingham Prasada Rao V.S.

  公开号：US20090286811A1

  公开（公告）日：2009-11-19

  The present invention provides transient receptor potential vanilloid (TRPV) modulators. In particular, compounds described herein are useful for treating or preventing diseases, conditions and/or disorders modulated by TRPV3. Also provided herein are processes for preparing compounds described herein, intermediates used in their synthesis, pharmaceutical compositions thereof, and methods for treating or preventing diseases, conditions and/or disorders modulated by TRPV3.

  本发明提供了瞬时受体电位香草酰基（TRPV）调节剂。具体而言，本文描述的化合物对于治疗或预防TRPV3调节的疾病、病况和/或障碍非常有用。本文还提供了制备上述化合物的过程、用于合成的中间体、它们的制药组合物以及治疗或预防TRPV3调节的疾病、病况和/或障碍的方法。
• Process for the preparation of fused pyrimidineone compounds useful as TRPV3 modulators
  申请人：Glenmark Pharmaceuticals S.A.

  公开号：EP2626360A1

  公开（公告）日：2013-08-14

  The present invention relates to processes for the preparation of compounds of formula (I) as well as to precursors for the preparation of compounds of formula (I).

  本发明涉及式（I）化合物的制备工艺以及制备式（I）化合物的前体。
• US8119647B2
  申请人：——

  公开号：US8119647B2

  公开（公告）日：2012-02-21
• US8518955B2
  申请人：——

  公开号：US8518955B2

  公开（公告）日：2013-08-27
• [EN] FUSED PYRIMIDINEONE COMPOUNDS AS TRPV3 MODULATORS<br/>[FR] COMPOSÉS DE PYRIMIDINONE CONDENSÉS À TITRE DE MODULATEURS DES TRP V3
  申请人：GLENMARK PHARMACEUTICALS SA

  公开号：WO2009130560A1

  公开（公告）日：2009-10-29

  The present invention provides transient receptor potential vanilloid (TRPV) modulators. In particular, compounds described herein are useful for treating or preventing diseases, conditions and/or disorders modulated by TRP V3. Also provided herein are processes for preparing compounds described herein, intermediates used in their synthesis, pharmaceutical compositions thereof, and methods for treating or preventing diseases, conditions and/or disorders modulated by TRPV3.