Succinic acid methyl ester phenyl ester | 3424-74-6

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯酚酯
• 英文名称: Succinic acid methyl ester phenyl ester
• 英文别名: 1-Methyl 4-phenyl butanedioate；1-O-methyl 4-O-phenyl butanedioate
• CAS: 3424-74-6
• 化学式: C₁₁H₁₂O₄
• 分子量: 208.214
• InChiKey: GPOYYABQCXVBCU-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.4
• 重原子数：
  15
• 可旋转键数：
  6
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.27
• 拓扑面积：
  52.6
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  丁二酸单甲酯 、 2-(三甲基硅)苯基三氟甲烷磺酸盐 在 sodium hydroxide 、 cesium fluoride 作用下， 以 乙腈 为溶剂， 反应 4.17h， 生成 Methyl 4-(2-Hydroxyphenyl)-4-oxobutanoate 、 Succinic acid methyl ester phenyl ester
  参考文献：
  名称：

  The insertion of arynes into the O–H bond of aliphatic carboxylic acids

  摘要：

  The insertion of arynes into the O-H bond of aliphatic carboxylic acids promoted by sodium carboxylates is described. The reactions led to the formation of aryl carboxylates in good yields with good chemoselectivities under mild conditions. (C) 2015 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2015.08.019

文献信息

• Free radical-mediated carboxylation by radical reaction of alkyl iodides with methyl oxalyl chloride
  作者：Sunggak Kim、Sang Yong Jon

  DOI：10.1016/s0040-4039(98)01568-8

  日期：1998.10

  Free radical-mediated carboxylation is achieved by treatment of alkyl iodides with methyl oxalyl chloride and bis(tributyltin) in benzene at 350 nm to afford the corresponding acid chlorides as a major product along with a small amount of the methyl esters.

  自由基介导的羧化反应是通过在350 nm下用甲基乙二酰氯和双（三丁基锡）在苯中处理烷基碘化物而得到的，作为主要产物的相应酰氯以及少量甲酯。
• Breast cancer resistance protein (bcrp) inhibitor
  申请人：Yamazaki Ryuta

  公开号：US20060128636A1

  公开（公告）日：2006-06-15

  The invention provides a drug which inhibits BCRP. A breast cancer resistance protein inhibitor containing, as an active ingredient, a diphenylacrylonitrile derivative represented by the following formula (1): [wherein, each of 8 R's, which are the same or different from one another, represents a hydrogen atom, a hydroxyl group, a nitro group, an amino group, an acetylamino group (—NHCOCH 3 group); a cyano group (—CN group); a formyl group (—CHO group), —COOR 1 (R 1 is hydrogen or C1-C4 alkyl), —O(CH 2 ) n COOR 2 (n=1−7: R 2 is hydrogen or C1-C4 alkyl), —OOCCH 2 CH 2 COOR 3 (R 3 is hydrogen, C1-C4 alkyl, (Z)-2-(3,4-dimethoxy-phenyl)-3-(4-hydroxy-phenyl)-acrylonitrile, or glycopyranosyl), a C1-C8 alkoxy group, a C1-C4 alkyl group, a halogen atom, a C1-C4 alkoxy C1-C4 alkoxy C1-C4 alkoxy group, a C2-C8 acyloxy group, a C2-C8 halogenoacyloxy group, a methylenedioxy group, a trifluoromethyl group, a phosphate group (i.e., —OP(O) (OH) 2 ) or a salt thereof, a sulfate group (i.e., —OSO 3 H) or a salt thereof, a glycopyranosyl group or a salt thereof, a phosphate ester of a glycopyranosyl group or a salt of the ester, a sulfate ester of a glycopyranosyl group or a salt of the ester, or a piperidinopiperidinocarbonyloxy group], an ester thereof, or a salt thereof.

  本发明提供了一种抑制BCRP的药物。一种含有以下式（1）所表示的二苯乙烯腈衍生物作为活性成分的乳腺癌耐药蛋白抑制剂：[其中，8个R分别表示氢原子、羟基、硝基、氨基、乙酰氨基（—NHCOCH3基）、氰基（—CN基）、甲酰基（—CHO基）、—COOR1（R1为氢或C1-C4烷基）、—O（CH2）nCOOR2（n = 1-7：R2为氢或C1-C4烷基）、—OOCCH2CH2COOR3（R3为氢、C1-C4烷基、（Z）-2-（3,4-二甲氧基苯基）-3-（4-羟基苯基）-丙烯腈或葡萄糖基）、C1-C8烷氧基、C1-C4烷基、卤原子、C1-C4烷氧基C1-C4烷氧基C1-C4烷氧基、C2-C8酰氧基、C2-C8卤代酰氧基、亚甲二氧基基团、三氟甲基基团、磷酸酯基团（即—OP（O）（OH）2）或其盐、硫酸酯基团（即—OSO3H）或其盐、葡萄糖基或其盐、葡萄糖基的磷酸酯或酯的盐、葡萄糖基的硫酸酯或酯的盐，或者是它的酯或盐。
• COMPONENTS AND CATALYSTS FOR THE POLYMERIZATION OF OLEFINS
  申请人：Basell Poliolefine Italia S.P.A.

  公开号：EP1539838A1

  公开（公告）日：2005-06-15
• POLYESTER COPOLYMER
  申请人：Avantium Knowledge Centre B.V.

  公开号：EP3625283A1

  公开（公告）日：2020-03-25
• Polyester Copolymer
  申请人：Avantium Knowledge Centre B.V.

  公开号：US20210139645A1

  公开（公告）日：2021-05-13

  A polyester copolymer, having a number average molecular weight of equal to or more than 4000 grams/mole and having a glass transition temperature of less than 160° C., containing: (a) in the range from equal to or more than 45 mole % to equal to or less than 50 mole %, based on the total amount of moles of monomer units within the polyester copolymer, of one or more bicyclic diol monomer units, wherein such one or more bicyclic diol monomer units is/are derived from one or more bicyclic diols chosen from the group consisting of isosorbide, isoidide, isomannide, 2,3:4,5-di-O-methylene-galactitol and 2,4:3,5-di-O-methylene-D-mannitol; (b) in the range from equal to or more than 25 mole % to equal to or less than 49.9 mole %, based on the total amount of moles of monomer units within the polyester copolymer, of an oxalate monomer unit; (c) in the range from equal to or more than 0.1 mole % to equal to or less than 25 mole %, based on the total amount of moles of monomer units within the polyester copolymer, of one or more linear C3-C12 dicarboxylate monomer units; and (d) optionally equal to or more than 0 mole % to equal to or less than 5 mole %, based on the total amount of moles of monomer units within the polyester copolymer, of one or more additional monomer units. A process for producing such a polyester copolymer, a composition containing such polyester copolymer, a method for manufacturing an article comprising the use of one or more of such polyester copolymers and an article obtained or obtainable by such a method.