bis-(1-phenyl-allyl)-ether | 107513-50-8

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: bis-(1-phenyl-allyl)-ether
• 英文别名: Bis-(1-phenyl-allyl)-aether；phenylallyl ether；Bis(vinylbenzyl) ether；1-(1-phenylprop-2-enoxy)prop-2-enylbenzene
• CAS: 107513-50-8
• 化学式: C₁₈H₁₈O
• 分子量: 250.34
• InChiKey: YUAYXCGERFHZJE-UHFFFAOYSA-N

物化性质

• 沸点：
  345.6±11.0 °C(Predicted)
• 密度：
  1.013±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  4.8
• 重原子数：
  19
• 可旋转键数：
  6
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.11
• 拓扑面积：
  9.2
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  bis-(1-phenyl-allyl)-ether 、 氢碘酸 生成 alkaline earth salt of/the/ methylsulfuric acid
  参考文献：
  名称：

  Meisenheimer; Link, Justus Liebigs Annalen der Chemie, 1930, vol. 479, p. 211,248

  摘要：

  DOI：
• 作为产物：
  描述：

  phenylmagnesium bromide 在 乙醚 、 硫酸 作用下， 生成 bis-(1-phenyl-allyl)-ether
  参考文献：
  名称：

  Meisenheimer; Link, Justus Liebigs Annalen der Chemie, 1930, vol. 479, p. 211,248

  摘要：

  DOI：

文献信息

• ENZYMATICALLY AND HYDROLYTICALLY STABLE RESINS, RESIN MONOMERS, AND RESIN COMPOSITES FOR USE IN DENTAL PREVENTIVE AND RESTORATIVE APPLICATIONS
  申请人：ADA Foundation

  公开号：US20150257986A1

  公开（公告）日：2015-09-17

  A composition of matter includes one or more functionalized vinylbenzyl components of the formula covalently connected to one or more R functional components; the one or more R functional groups selected from a group including one or more hydroxyl methyl (—CHOH—) moieties and/or derivatives thereof, one or more ethoxy (—CH 2 —CH 2 —O—) moieties and/or derivatives thereof, and one or more benzene (C 6 H 6 ) and/or derivatives thereof; and ether links that connect the functionalized vinylbenzyl components and the R functional components.

  一种物质的组成包括一个或多个功能化的乙烯苯基组分，其化学式为与一个或多个R功能组分共价连接；所述一个或多个R功能基从包括一个或多个羟甲基（—CHOH—）基团及/或其衍生物、一个或多个乙氧基（—CH2—CH2—O—）基团及/或其衍生物、一个或多个苯基（C6H6）及/或其衍生物的群组中选择；以及连接功能化的乙烯苯基组分和R功能组分的醚键。
• [EN] PROCESS FOR PREPARATION OF PROSTACYCLIN DERIVATIVES<br/>[FR] PROCÉDÉ DE PRÉPARATION DE DÉRIVÉS DE PROSTACYCLINE
  申请人：EMCURE PHARMACEUTICALS LTD

  公开号：WO2017130109A1

  公开（公告）日：2017-08-03

  Disclosed is an improved method of synthesis for Treprostinil comprising condensation reaction of compound (4) with a hydroxyl-protected alkynol (5) to give the condensation product, compound (6). Subjecting compound (6) to oxidation, reduction, hydroxyl protection and carbonylation, cyclization reactions gives the tricyclic derivative (10). Further reactions comprising reduction, hydrogenation and deprotection of the phenolic and side-chain hydroxyl groups, wherein the sequence and choice of reagents is governed by protecting groups, give the triol intermediate, compound (14). Cyanoalkylation at phenolic hydroxyl functionality and further hydrolysis yields the prostacyclin compound, Treprostinil (1) and its pharmaceutically acceptable salts with desired purity.

  揭示了一种改进的Treprostinil合成方法，包括将化合物（4）与羟基保护的炔醇（5）进行缩合反应，得到缩合产物，化合物（6）。将化合物（6）进行氧化、还原、羟基保护和羰基化、环化反应，得到三环衍生物（10）。进一步的反应包括还原、氢化和去保护酚基和侧链羟基，其中试剂的顺序和选择受到保护基的控制，得到三醇中间体，化合物（14）。在酚羟基官能团上进行氰基烷基化，进一步水解产生前列环素化合物Treprostinil（1）及其具有所需纯度的药用盐。
• Processes for preparing of glucopyranosyl-substituted (ethynyl-benzyl)-benzene derivatives and intermediates thereof
  申请人：ECKHARDT Matthias

  公开号：US20070073046A1

  公开（公告）日：2007-03-29

  The present invention relates to processes for preparing the compounds of general formula I, wherein the groups R 1 , R 2 and R 3 are defined according to claim 1 and to intermediates of said processes.

  本发明涉及制备一般式I化合物的过程，其中基团R1、R2和R3根据权利要求1定义，并涉及所述过程的中间体。
• Processes for preparing of glucopyranosyl-substituted benzyl-benzene derivatives and intermediates therein
  申请人：Eckhardt Matthias

  公开号：US20060258749A1

  公开（公告）日：2006-11-16

  The present invention relates to processes for preparing the compounds of general formula I, wherein the groups R 1 and R 3 are defined according to claim 1. Furthermore this inventions relates to intermediates obtained in these processes.

  本发明涉及制备一般式I化合物的过程，其中基团R1和R3根据权利要求1定义。此外，本发明涉及在这些过程中获得的中间体。
• A Mild Synthesis of Unsymmetrical Bisalkoxysilanes through Catalyzed Alcoholysis of Hydridosilanes Containing C−C Multiple Bonds and Aryl Halides
  作者：Colleen N. Scott、Craig S. Wilcox

  DOI：10.1021/jo9022765

  日期：2010.1.1

  The synthesis of unsymmetrical bisalkoxysilanes containing unsaturated C−C bonds and alkyl and aryl bromides has been developed. This method is a modification of our previously reported two-step procedure that utilizes readily available catalysts (rhodium acetate dimer and manganese pentacarbonyl bromide) under mild neutral aprotic conditions. Good to moderate yields of the products were obtained in

  已经开发了包含不饱和CC键以及烷基和芳基溴化物的不对称双烷氧基硅烷的合成。该方法是对我们先前报道的两步程序的改进，该程序使用了在中性非质子条件下易于获得的催化剂（乙酸铑二聚体和五羰基锰锰）。在短时间内获得了良好至中等产量的产品。在该两步合成中，可以有效地制备具有可以进一步官能化的基团的不对称双烷氧基硅烷，而无需分离中间体。