2-[(3-苯氧基苯甲酰基)氨基]乙烷磺酸 | 69519-14-8

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 中文名称: 2-[(3-苯氧基苯甲酰基)氨基]乙烷磺酸
• 英文名称: N-(3-Phenoxybenzoyl)taurine
• 英文别名: 2-[(3-phenoxybenzoyl)amino]ethanesulfonic acid
• CAS: 69519-14-8
• 化学式: C₁₅H₁₅NO₅S
• 分子量: 321.3
• InChiKey: GJNBCGLRQJUPBW-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.6
• 重原子数：
  22
• 可旋转键数：
  6
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.13
• 拓扑面积：
  101
• 氢给体数：
  2
• 氢受体数：
  5

文献信息

• Geminal diphenyl derivatives and their use in immunoassays
  申请人：SYNTEX (U.S.A.) INC.

  公开号：EP0375439A2

  公开（公告）日：1990-06-27

  Methods are disclosed for inactivating interfering binding proteins in a immunoassay for a member of a specific binding pair (sbp). The method comprises including in an assay medium containing a sample suspected of containing an sbp member and an interfering binding protein an effective amount of a water soluble compound having two substituted or unsubstituted phenyl groups linked to a common atom. When the sbp member or its sbp partner has two phenyl groups linked to a common atom, the compound has a number of groups other than hydrogen attached to the phenyl groups and the atom that differs by at least two from the number of such groups on the sbp member. When the sbp member or its sbp partner has two phenyl groups linked to a common atom and the binding protein is not an antibody, the compound has only one group other than hydrogen attached to a phenyl group or the common atom. The methods have particular application in avoiding cross-reactivity of non-analyte materials in a sample with immunochemical reagents used in such assay. The methods have application also in disrupting complexes between an analyte to be determined and other materials so that one can accurately determine the amount of an analyte in a sample.

  本发明公开了在特异性结合对（sbp）成员的免疫测定中灭活干扰结合蛋白的方法。该方法包括在含有疑似含有 sbp 成员和干扰结合蛋白的样品的检测介质中加入有效量的水溶性化合物，该化合物具有两个与一个共同原子相连的取代或未取代的苯基。当 sbp 成员或其 sbp 伙伴有两个苯基与一个共同原子相连时，该化合物中连接到苯基和原子上的除氢以外的基团数目与 sbp 成员上的此类基团数目相差至少两个。当 sbp 成员或其 sbp 伙伴有两个苯基与一个公共原子相连，且结合蛋白不是抗体时，化合物除氢外只有一个基团与苯基或公共原子相连。这些方法特别适用于避免样品中的非分析物与用于此类检测的免疫化学试剂产生交叉反应。这些方法还可用于破坏待测定的分析物与其它物质之间的复合物，从而准确测定样品中分析物的含量。
• US5063165A
  申请人：——

  公开号：US5063165A

  公开（公告）日：1991-11-05
• US5256575A
  申请人：——

  公开号：US5256575A

  公开（公告）日：1993-10-26
• US5378636A
  申请人：——

  公开号：US5378636A

  公开（公告）日：1995-01-03