18'-Hydroxyspiro[2-benzofuran-3,14'-9,21-dioxapentacyclo[11.8.0.02,10.04,8.015,20]henicosa-1(13),2(10),3,11,15(20),16,18-heptaene]-1,5'-dione | 1227854-93-4

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并吡喃
• 英文名称: 18'-Hydroxyspiro[2-benzofuran-3,14'-9,21-dioxapentacyclo[11.8.0.02,10.04,8.015,20]henicosa-1(13),2(10),3,11,15(20),16,18-heptaene]-1,5'-dione
• 英文别名: 18'-hydroxyspiro[2-benzofuran-3,14'-9,21-dioxapentacyclo[11.8.0.02,10.04,8.015,20]henicosa-1(13),2(10),3,11,15(20),16,18-heptaene]-1,5'-dione
• CAS: 1227854-93-4
• 化学式: C₂₆H₁₆O₆
• 分子量: 424.409
• InChiKey: KDSJWOZBFZXPKA-UHFFFAOYSA-N

物化性质

• 沸点：
  709.9±60.0 °C(Predicted)
• 密度：
  1.59±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  3.7
• 重原子数：
  32
• 可旋转键数：
  0
• 环数：
  7.0
• sp3杂化的碳原子比例：
  0.15
• 拓扑面积：
  82.1
• 氢给体数：
  1
• 氢受体数：
  6

反应信息

• 作为反应物：
  描述：

  L-高半胱氨酸 、 18'-Hydroxyspiro[2-benzofuran-3,14'-9,21-dioxapentacyclo[11.8.0.02,10.04,8.015,20]henicosa-1(13),2(10),3,11,15(20),16,18-heptaene]-1,5'-dione 以 乙腈 为溶剂， 生成
  参考文献：
  名称：

  A thiol-specific fluorescent probe and its application for bioimaging

  摘要：

  一种基于荧光素的荧光探针对硫醇表现出优异的选择性和灵敏度，并描述了其在生物成像中的应用。

  DOI：

  10.1039/b925453f
• 作为产物：
  描述：

  fluorescein monoaldehyde 、 2-环戊烯酮 在 咪唑 作用下， 以 四氢呋喃 、 水 为溶剂， 反应 72.0h， 以21%的产率得到18'-Hydroxyspiro[2-benzofuran-3,14'-9,21-dioxapentacyclo[11.8.0.02,10.04,8.015,20]henicosa-1(13),2(10),3,11,15(20),16,18-heptaene]-1,5'-dione
  参考文献：
  名称：

  A thiol-specific fluorescent probe and its application for bioimaging

  摘要：

  一种基于荧光素的荧光探针对硫醇表现出优异的选择性和灵敏度，并描述了其在生物成像中的应用。

  DOI：

  10.1039/b925453f

文献信息

• Diagnostic devices with modifiable hydrophobic surfaces
  申请人：Siemens Healthcare Diagnostics Inc.

  公开号：US10449536B2

  公开（公告）日：2019-10-22

  A diagnostic device 10 for screening for a target analyte in a sample is provided. The diagnostic device 10 comprises a substrate 12 and a hydrophobic material 20 disposed on the substrate. The hydrophobic material 20 is selected to be converted from the hydrophobic material 20 to a hydrophilic material 22 upon contact with a conversion component within or derived from a sample introduced to the device 10.

  提供了一种用于筛查样品中目标分析物的诊断装置 10。诊断设备 10 包括基底 12 和基底上的疏水材料 20。疏水材料 20 被选择为在与引入装置 10 的样品内或样品中的转换成分接触时，从疏水材料 20 转换为亲水材料 22。
• 细胞及生物体内生物硫醇检测与特异性快速标记巯基蛋白质的荧光探针、制备方法及应用
  申请人：南京工业大学

  公开号：CN114853779A

  公开（公告）日：2022-08-05

  本发明公开了一种细胞内生物硫醇检测与特异性快速标记巯基蛋白质的荧光探针，该探针是可以高选择性和高灵敏度检测生物硫醇的免洗荧光探针，同时还可以对巯基蛋白质进行快速标记。本发明的探针是具有如式I结构所示的3'‑(二乙氨基)‑6'‑羟基‑3‑环内酯‑氧杂蒽环衍生物或3',6'‑2羟基‑3‑环内酯‑氧杂蒽环衍生物： 其中R为OH或N(CH3)2。
• Colorimetric and fluorometric assays for acetylcholinesterase and its inhibitors screening based on a fluorescein derivate
  作者：Bihui Wang、Huilin Wang、Fang Wang、Guodong Zhou、Yong Wang、Srinivasulu Kambam、Xiaoqiang Chen

  DOI：10.1016/j.bmcl.2013.12.019

  日期：2014.1

  A fluorescein-based sensor was developed for the AChE activity assay and the inhibitor screening. The sensor provided the dual assay methods for the screening of AChE activity in the presence or absence of inhibitor. The colorimetric and fluorometric assays were based on the following processes: (1) owing to the hydrolysis of acetylthiocholine in the presence of AChE, the fluorescein-based probe can rapidly induce 1,4-addition of the hydrolysis product thiocholine to alpha,beta-unsaturated ketone in the compound 1, resulting in strong fluorescence and absorption changes; (2) in the presence of the corresponding inhibitor, the fluorescence enhancement or the absorption change would be inhibited in that the formation of thiocholine was hindered. Crown Copyright (C) 2013 Published by Elsevier Ltd. All rights reserved.
• DIAGNOSTIC DEVICES WITH MODIFIABLE HYDROPHOBIC SURFACES
  申请人：Siemens Healthcare Diagnostics Inc.

  公开号：US20170246627A1

  公开（公告）日：2017-08-31

  A diagnostic device 10 for screening for a target analyte in a sample is provided. The diagnostic device 10 comprises a substrate 12 and a hydrophobic material 20 disposed on the substrate. The hydrophobic material 20 is selected to be converted from the hydrophobic material 20 to a hydrophilic material 22 upon contact with a conversion component within or derived from a sample introduced to the device 10.
• [EN] DIAGNOSTIC DEVICES WITH MODIFIABLE HYDROPHOBIC SURFACES<br/>[FR] DISPOSITIFS DE DIAGNOSTIC À SURFACES HYDROPHOBES MODIFIABLES
  申请人：SIEMENS HEALTHCARE DIAGNOSTICS

  公开号：WO2016036658A1

  公开（公告）日：2016-03-10

  A diagnostic device 10 for screening for a target analyte in a sample is provided. The diagnostic device 10 comprises a substrate 12 and a hydrophobic material 20 disposed on the substrate. The hydrophobic material 20 is selected to be converted from the hydrophobic material 20 to a hydrophilic material 22 upon contact with a conversion component within or derived from a sample introduced to the device 10.