diethyl 2-(9-fluorenyl)malonate | 76765-79-2

• 分子结构分类: 有机化合物 - 苯类化合物 - 芴
• 英文名称: diethyl 2-(9-fluorenyl)malonate
• 英文别名: Diethyl 2-(9H-fluoren-9-yl)malonate；diethyl 2-(9H-fluoren-9-yl)propanedioate
• CAS: 76765-79-2
• 化学式: C₂₀H₂₀O₄
• 分子量: 324.376
• InChiKey: ZXUJOWGOAYXFAA-UHFFFAOYSA-N

物化性质

• 熔点：
  70-71 °C
• 沸点：
  437.9±20.0 °C(Predicted)
• 密度：
  1.186±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  4
• 重原子数：
  24
• 可旋转键数：
  7
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.3
• 拓扑面积：
  52.6
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  diethyl 2-(9-fluorenyl)malonate 生成 9-芴乙酸
  参考文献：
  名称：

  CORNEA F.; IONESCU D.; ZGLOBIU M.; BOTEZ G.; DOBRE V.; NICULESCU-DUVAZ I., REV. ROUM. CHIM., 1980, 25, NO 5, 701-711

  摘要：

  DOI：
• 作为产物：
  描述：

  9-羟基芴 在 乙醇 、 苯 作用下， 生成 diethyl 2-(9-fluorenyl)malonate
  参考文献：
  名称：

  The Synthesis of 2-, 4- and 9-Fluoreneacetic Acid

  摘要：

  DOI：

  10.1021/ja01867a025

文献信息

• Cyclic compounds useful in the treatment of dyslipidaemia, atherosclerosis and diabetes, pharamaceutical compositions and preparation process
  申请人：Merck Patentgesellschaft

  公开号：US06528538B1

  公开（公告）日：2003-03-04

  The present invention relates to cyclic compounds which are of the class of compounds of formula I wherein X and Y represent an oxygen atom and to processes for preparing such compounds. The compounds are useful in the treatment of dyslipidemia, atherosclerosis, and diabetes.

  本发明涉及一类化合物，其为式I化合物，其中X和Y代表氧原子，以及制备此类化合物的方法。这些化合物在治疗血脂异常、动脉粥样硬化和糖尿病方面有用。
• Determination of Thermodynamic Affinities of Various Polar Olefins as Hydride, Hydrogen Atom, and Electron Acceptors in Acetonitrile
  作者：Ying Cao、Song-Chen Zhang、Min Zhang、Guang-Bin Shen、Xiao-Qing Zhu

  DOI：10.1021/jo4010926

  日期：2013.7.19

  thermodynamic affinities of the hydrogen adducts of the polar olefins (XH•) obtaining electrons in acetonitrile were determined using titration calorimetry and electrochemical methods. The pure C═C π-bond heterolytic and homolytic dissociation energies of the polar olefins (X) in acetonitrile and the pure C═C π-bond homolytic dissociation energies of the radical anions of the polar olefins (X•–) in acetonitrile

  合成了一系列具有各种典型结构（X）的69种极性烯烃，并获得了氢化物阴离子，氢原子和电子的极性烯烃的热力学亲和力（以摩尔焓变或标准氧化还原电势定义）。利用滴定热法和电化学法测定了极性烯烃（X •–）的质子和氢原子的自由基阴离子的热力学亲和力和极性烯烃（XH •）的电子在乙腈中的电子的热力学亲和力。方法。极性烯烃的纯C═Cπ键杂化和均解离能（X）和乙腈中极性烯烃（X •–）的自由基阴离子的纯C═Cπ键均解离能。使用Hammett线性自由能关系研究了远程取代基对极性烯烃及其相关反应中间体的六个热力学亲和力的影响；结果表明，哈米特线性自由能关系在六个化学和电化学过程中均成立。这项工作中公开的信息不仅可以弥补烯烃作为一类非常重要的有机不饱和化合物的化学热力学的空白，而且可以极大地促进烯烃化学和应用的快速发展。
• Turn-off Fluorescence Chemosensor for Iron with Bis(2-aminoethyl)-2-(9-fluorenyl)malonamide Functionlized SBA-15
  作者：Marzieh Yadavi、Alireza Badiei

  DOI：10.1007/s10895-013-1321-8

  日期：2014.3

  An bis(2-aminoethyl)-2-(9-fluorenyl)malonamide as fluorophore ligand was immobilized onto mesoporous silica type SBA-15 via post synthesis grafting. The obtained material was characterized by small and wide angle X-ray diffraction, N2 adsorption–desorption, Fourier transform infrared spectroscopy, Raman spectroscopy and thermogravimetric analysis that indicate the successful immobilization of the ligand on the surface of mesoporous silica. The sensing ability of the obtained material was studied by addition of the cations Fe3+, Mg2+, Cr3+, Co2+, Ni2+, Cu2+, Hg2+ and Zn2+ to water suspensions of the assayed solid. Of all the cations tested addition of Fe3+ ion to a suspension of this material resulted in the largest decrease in the fluorescence intensity. Turn-off photoluminescence of this material was remarkably observed for iron ions in comparing of the other cations. A good linearity between the fluorescence intensity of this material and the concentration of Fe3+ ion is constructed, which enables it as a fluorescence chemosensor for detecting the Fe3+ ion with a suitable detection limit of 1.35 × 10−5. It can be introduced as a novel fluorescent sensor in aqueous solution for a lot of practical applications in chemical, environmental and biological systems.

  一种双(2-氨基乙基)-2-(9-芴基)马隆酰胺作为荧光探针配体，通过后合成接枝法固定到介孔硅材料SBA-15上。所获得的材料通过小角和宽角X射线衍射、氮气吸附-脱附、傅里叶变换红外光谱、拉曼光谱和热重分析进行表征，结果表明配体成功固定在介孔硅的表面。通过将Fe³⁺、Mg²⁺、Cr³⁺、Co²⁺、Ni²⁺、Cu²⁺、Hg²⁺和Zn²⁺等阳离子添加到被检测固体的水悬浊液中，研究了所获得材料的传感能力。在所有测试的阳离子中，向该材料悬浊液中添加Fe³⁺离子导致荧光强度下降最大。与其他阳离子相比，该材料对铁离子的关闭光致光发光表现出显著的效果。该材料的荧光强度与Fe³⁺离子的浓度之间建立了良好的线性关系，使其成为检测Fe³⁺离子的荧光化学传感器，具有适合的检测限为1.35 × 10⁻⁵。它可以作为一种新型荧光传感器在水溶液中应用于许多实际的化学、环境和生物系统中。
• New Fluorenyl-Substituted Dioxotetraamine Ligands and Their Copper(II) Complexes − Crystal Structure and Fluorescent Sensing Properties in Aqueous Solution
  作者：Li-Jian Jiang、Qin-Hui Luo、Qing-Xiang Li、Meng-Chang Shen、Hong-Wen Hu

  DOI：10.1002/1099-0682(200203)2002:3<664::aid-ejic664>3.0.co;2-n

  日期：2002.3

  10-tetraazadecane-5,6-dione (L2) along with their copper(II) complexes have been synthesized. Their properties were examined by ES-MS and CV in aqueous solution and the crystal structure of the copper(II) complex of L1 has also been determined. The recognition of the transition metal ions (Cu2+, Ni2+, etc.) by receptors has been studied in aqueous solutions using pH-potentiometric and fluorimetric titrations

  由芴基和二氧四氮杂单元组成的两个新配体，即 2,10-diamino-6-(9H-fluoren-9-yl)-4,8-​​diazaundecane-5,7-dione (L1) 和 1-(9H -fluoren-9-yl)-1,4,7,10-tetraazadecane-5,6-dione (L2) 及其铜 (II) 配合物已被合成。在水溶液中通过 ES-MS 和 CV 检查它们的性质，并且还确定了 L1 的铜 (II) 配合物的晶体结构。已经使用 pH 电位滴定和荧光滴定在水溶液中研究了受体对过渡金属离子（Cu2+、Ni2+ 等）的识别。结果表明，Cu2+或Ni2+离子与L1结合导致芴基荧光猝灭，相反L2荧光增强。讨论了这些机制。
• [EN] CYCLIC COMPOUNDS USEFUL IN THE TREATMENT OF DYSLIPIDAEMIA, ATHEROSCLEROSIS AND DIABETES, PHARMACEUTICAL COMPOSITIONS AND PREPARATION PROCESS<br/>[FR] COMPOSES CYCLIQUES UTILES DANS LE TRAITEMENT DE DYSLIPIDEMIE, D'ATHEROSCLEROSE ET DE DIABETES, COMPOSITIONS PAHARMACEUTIQUES ET PROCEDES DE PREPARATION ASSOCIES
  申请人：MERCK PATENT GMBH

  公开号：WO2000004011A1

  公开（公告）日：2000-01-27

  The present invention relates to cyclic compounds which can be used in the treatment of dyslipidaemia, atherosclerosis and diabetes, to processes for preparing these compounds. The compounds of the invention correspond to formula (I) wherein the radicals X, Y, R, R1, R2, R3, R4, R5, R6, R7 have meanings as given in claim 1.

  本发明涉及可用于治疗血脂异常、动脉粥样硬化和糖尿病的环状化合物，以及制备这些化合物的过程。本发明的化合物对应于式（I），其中基团X，Y，R，R1，R2，R3，R4，R5，R6，R7的含义如权利要求书1所述。