4-methyl-2-(p-fluorophenyl)pyrimidine | 76128-67-1

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 4-methyl-2-(p-fluorophenyl)pyrimidine
• 英文别名: 4-Methyl-2-(4-fluorophenyl)pyrimidine；2-(4-fluorophenyl)-4-methylpyrimidine
• CAS: 76128-67-1
• 化学式: C₁₁H₉FN₂
• 分子量: 188.204
• InChiKey: VBJIQJBILYYFQY-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.4
• 重原子数：
  14
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.09
• 拓扑面积：
  25.8
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  4-氟苄脒盐酸盐 、 4-chloro-3-buten-2-one 在 sodium hydroxide 作用下， 反应 5.0h， 以68%的产率得到4-methyl-2-(p-fluorophenyl)pyrimidine
  参考文献：
  名称：

  Reactivity constants of 4-substituted 2-pyrimidyl groups

  摘要：

  DOI：

  10.1007/bf00950569

文献信息

• Aminopiperidines as Dipeptidyl Peptidase-IV Inhibitors for the Treatment or Prevention of Diabetes
  申请人：Cox M. Jason

  公开号：US20080076773A1

  公开（公告）日：2008-03-27

  The present invention is directed to novel substituted aminopiperidines which are inhibitors of the dipeptidyl peptidase-IV enzyme (“DPP-IV inhibitors”) and which are useful in the treatment or prevention of diseases in which the dipeptidyl peptidase-IV enzyme is involved, such as diabetes and particularly Type 2 diabetes. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which the dipeptidyl peptidase-IV enzyme is involved.

  本发明涉及一种新型的取代氨基哌啶，它是二肽基肽酶-IV酶（“DPP-IV酶”）的抑制剂，并且在治疗或预防DPP-IV酶参与的疾病，如糖尿病，尤其是2型糖尿病方面具有用处。本发明还涉及包含这些化合物的制药组合物，以及使用这些化合物和组合物在预防或治疗DPP-IV酶参与的这些疾病方面的用途。
• US7884104B2
  申请人：——

  公开号：US7884104B2

  公开（公告）日：2011-02-08
• [EN] IMIDAZO-PYRIMIDINE DERIVATIVES AS LIGANDS FOR GABA RECEPTORS<br/>[FR] DERIVES D'IMIDAZO-PYRIMIDINE EN TANT QUE LIGANDS POUR RECEPTEURS GABA
  申请人：MERCK SHARP & DOHME

  公开号：WO2002076983A1

  公开（公告）日：2002-10-03

  A class of imidazo[1,2-α]pyrimidine derivatives, substituted at the 3-position by an optionally substituted five-membered or six-membered heteroaromatic ring, are selective ligands for GABAA receptors, in particular having good affinity for the α2 and/or α3 and/or α5 subunit thereof, and are accordingly of benefit in the treatment and/or prevention of adverse conditions of the central nervous system, including anxiety, convulsions and cognitive disorders.
• Reactivity constants of 4-substituted 2-pyrimidyl groups
  作者：S. G. Baram、O. P. Shkurko、V. P. Mamaev

  DOI：10.1007/bf00950569

  日期：1980.8