(E)-cyclohexyl(oct-1-enyl)sulfane | 1332526-11-0

• 分子结构分类: 有机化合物 - 有机硫化合物 - 硫醚类
• 英文名称: (E)-cyclohexyl(oct-1-enyl)sulfane
• 英文别名: [(E)-oct-1-enyl]sulfanylcyclohexane
• CAS: 1332526-11-0
• 化学式: C₁₄H₂₆S
• 分子量: 226.426
• InChiKey: LDJXQBKWBBDGPE-JLHYYAGUSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6
• 重原子数：
  15
• 可旋转键数：
  7
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.86
• 拓扑面积：
  25.3
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为产物：
  描述：

  环己硫醇 、 反式-1-碘-1-辛烯 在 copper(I) oxide 、 potassium hydroxide 作用下， 以 1,4-二氧六环 为溶剂， 反应 12.0h， 以92%的产率得到(E)-cyclohexyl(oct-1-enyl)sulfane
  参考文献：
  名称：

  Efficient Copper-Catalyzed S-Vinylation of Thiols with Vinyl Halides

  摘要：

  The synthesis of vinyl sulfides through the coupling reaction of thiols with vinyl iodides, bromides, and chlorides is described. The thiols can couple with aryl iodides in the presence of only 0.5 mol % Cu2O without the need for an ancillary ligand. In the presence of 5 mol % of Cu2O and 10 mol % 1,10-phenanthroline as the ligand, the more challenging alkyl vinyl bromides can also be coupled with thiols, giving the vinyl sulfides in good to excellent yields.

  DOI：

  10.1021/ol2020863

文献信息

• Efficient Copper-Catalyzed S-Vinylation of Thiols with Vinyl Halides
  作者：Hsin-Lun Kao、Chin-Fa Lee

  DOI：10.1021/ol2020863

  日期：2011.10.7

  The synthesis of vinyl sulfides through the coupling reaction of thiols with vinyl iodides, bromides, and chlorides is described. The thiols can couple with aryl iodides in the presence of only 0.5 mol % Cu2O without the need for an ancillary ligand. In the presence of 5 mol % of Cu2O and 10 mol % 1,10-phenanthroline as the ligand, the more challenging alkyl vinyl bromides can also be coupled with thiols, giving the vinyl sulfides in good to excellent yields.