(4E,6E)-1,10-dichloro-4,6-decadiene | 57404-73-6

• 分子结构分类: 有机化合物 - 有机卤素化合物 - 有机氯化物
• 英文名称: (4E,6E)-1,10-dichloro-4,6-decadiene
• 英文别名: 1,10-Dichlor-(4E,6E)-4,6-decadien；1,10-Dichlor-(4E,6E)-4,6-dodecadien；1,10-dichloro-deca-4t,6t-diene；(4E,6E)-1,10-dichlorodeca-4,6-diene
• CAS: 57404-73-6
• 化学式: C₁₀H₁₆Cl₂
• 分子量: 207.143
• InChiKey: FOZQIFDTJACRAS-ZPUQHVIOSA-N

物化性质

• 沸点：
  285.1±15.0 °C(Predicted)
• 密度：
  1.017±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  4
• 重原子数：
  12
• 可旋转键数：
  7
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.6
• 拓扑面积：
  0
• 氢给体数：
  0
• 氢受体数：
  0

反应信息

• 作为反应物：
  描述：

  (4E,6E)-1,10-dichloro-4,6-decadiene 在 sodium hydroxide 、 草酰氯 、 四丁基碘化铵 、 potassium carbonate 、 三乙胺 、 N,N-二甲基甲酰胺 作用下， 以 四氢呋喃 、 乙醇 、 苯 为溶剂， 反应 43.0h， 生成
  参考文献：
  名称：

  ACAT inhibitors derived from hetero-Diels-Alder cycloadducts of thioaldehydes

  摘要：

  Acyl-CoA:cholesterol acyltransferase (ACAT) is the enzyme largely responsible for intracellular cholesterol esterification. A systemic inhibitor of ACAT is believed to be able to slow or even reverse the atherosclerotic process. Towards that goal, a series of cyclic sulfides, derived from the hetero-Diels-Alder reaction of thioaldehydes with 1,3-dienes, and bearing carboxamide substituents, were prepared and evaluated for in vitro (in several tissues and species) and ex vivo ACAT inhibition. Minor changes in subsequent structure were found to have a significant effect in optimization of the biological activity of this series of compounds. Copyright (C) 1996 The DuPont Merck Pharmaceutical Company.

  DOI：

  10.1016/0968-0896(96)00143-5
• 作为产物：
  描述：

  5-氯戊炔 生成 (4E,6E)-1,10-dichloro-4,6-decadiene
  参考文献：
  名称：

  Stereospecific synthesis of symmetrical conjugated dienes with alkenylcopper intermediates from alkenyldialkylboranes

  摘要：

  DOI：

  10.1021/jo01291a045

文献信息

• Stereospecific synthesis of symmetrical conjugated dienes with alkenylcopper intermediates from alkenyldialkylboranes
  作者：James B. Campbell、Herbert C. Brown

  DOI：10.1021/jo01291a045

  日期：1980.2
• Reaction of alkenylboranes with methylcopper. A convenient new procedure for the synthesis of symmetrical (E,E)-1,3-dienes
  作者：Yoshinori Yamamoto、Hidetaka Yatagai、Kazuhiro Maruyama、Akio Sonoda、Shunichi Murahashi

  DOI：10.1021/ja00459a021

  日期：1977.8
• MOLANDER G. A.; ZINKE P. W., ORGANOMETALLICS, 5,(1986) N 10, 2161-2162
  作者：MOLANDER G. A.、 ZINKE P. W.

  DOI：——

  日期：——
• ACAT inhibitors derived from hetero-Diels-Alder cycloadducts of thioaldehydes
  作者：Richard G. Wilde、Jeffrey T. Billheimer、Sandie J. Germain、Elizabeth A. Hausner、Paul C. Meunier、Deborah A. Munzer、Janet K. Stoltenborg、Peter J. Gillies、Deborah L. Burcham、Shiew-Mai Huang、John D. Klaczkiewicz、Soo S. Ko、Ruth R. Wexler

  DOI：10.1016/0968-0896(96)00143-5

  日期：1996.9

  Acyl-CoA:cholesterol acyltransferase (ACAT) is the enzyme largely responsible for intracellular cholesterol esterification. A systemic inhibitor of ACAT is believed to be able to slow or even reverse the atherosclerotic process. Towards that goal, a series of cyclic sulfides, derived from the hetero-Diels-Alder reaction of thioaldehydes with 1,3-dienes, and bearing carboxamide substituents, were prepared and evaluated for in vitro (in several tissues and species) and ex vivo ACAT inhibition. Minor changes in subsequent structure were found to have a significant effect in optimization of the biological activity of this series of compounds. Copyright (C) 1996 The DuPont Merck Pharmaceutical Company.