5-cyclohexylthio-4-(3-methylbutyl)-5H-furan-2-one | 1330664-30-6

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二氢呋喃
• 英文名称: 5-cyclohexylthio-4-(3-methylbutyl)-5H-furan-2-one
• 英文别名: 2-cyclohexylsulfanyl-3-(3-methylbutyl)-2H-furan-5-one
• CAS: 1330664-30-6
• 化学式: C₁₅H₂₄O₂S
• 分子量: 268.42
• InChiKey: HMOSGBOCLUMBHI-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.5
• 重原子数：
  18
• 可旋转键数：
  5
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.8
• 拓扑面积：
  51.6
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  环己硫醇 、 5-甲基-1-已炔 、 一氧化碳 在 dicobalt octacarbonyl 作用下， 以 乙腈 为溶剂， 140.0 ℃ 、4.0 MPa 条件下， 反应 17.0h， 以68%的产率得到5-cyclohexylthio-4-(3-methylbutyl)-5H-furan-2-one
  参考文献：
  名称：

  Cobalt-Catalyzed Thiolative Lactonization of Alkynes with Double CO Incorporation

  摘要：

  When the Co-2(CO)(8)-catalyzed reaction of alkynes with thiols is conducted under the pressure of carbon monoxide, a novel thiolative lactonization with simultaneous introduction of two carbon monoxide molecules into the carbon carbon triple bonds takes place successfully to afford alpha,beta-unsaturated gamma-thio-gamma-lactones with excellent regioselectivity.

  DOI：

  10.1021/om200248f

文献信息

• Cobalt-Catalyzed Thiolative Lactonization of Alkynes with Double CO Incorporation
  作者：Yoshihiro Higuchi、Shingo Atobe、Michiru Tanaka、Ikuyo Kamiya、Takuya Yamamoto、Akihiro Nomoto、Motohiro Sonoda、Akiya Ogawa

  DOI：10.1021/om200248f

  日期：2011.9.12

  When the Co-2(CO)(8)-catalyzed reaction of alkynes with thiols is conducted under the pressure of carbon monoxide, a novel thiolative lactonization with simultaneous introduction of two carbon monoxide molecules into the carbon carbon triple bonds takes place successfully to afford alpha,beta-unsaturated gamma-thio-gamma-lactones with excellent regioselectivity.