2-[(9-氧代-9H-芴-2-基)氨基甲酰]苯甲酸 | 5411-64-3

• 分子结构分类: 有机化合物 - 苯类化合物 - 芴
• 中文名称: 2-[(9-氧代-9H-芴-2-基)氨基甲酰]苯甲酸
• 英文名称: 2-((9-oxo-9H-fluoren-2-yl)carbamoyl)benzoic acid
• 英文别名: NSC12404；N-(9-oxo-fluoren-2-yl)-phthalamic acid；N-(9-Oxo-fluoren-2-yl)-phthalamidsaeure；2-(9-oxo-9H-fluoren-2-ylcarbamoyl)benzoic acid；2-[(9-oxofluoren-2-yl)carbamoyl]benzoic acid
• CAS: 5411-64-3
• 化学式: C₂₁H₁₃NO₄
• 分子量: 343.339
• InChiKey: AFLSVPDXCXLNDA-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4
• 重原子数：
  26
• 可旋转键数：
  3
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  83.5
• 氢给体数：
  2
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  2-[(9-氧代-9H-芴-2-基)氨基甲酰]苯甲酸 在 溶剂黄146 作用下， 生成 N-(9-oxo-fluoren-2-yl)-phthalimide
  参考文献：
  名称：

  DERIVATIVES OF FLUORENE. I. N-SUBSTITUTED 2-AMINOFLUORENE AND 2-AMINOFLUORENONE¹

  摘要：

  DOI：

  10.1021/jo01365a011

文献信息

• LPA2 Receptor-Specific Benzoic Acid Derivatives
  申请人：University of Tennessee Research Foundation

  公开号：US20140057936A1

  公开（公告）日：2014-02-27

  Disclosed are compounds effective for inhibiting cellular apoptosis and for protecting cells and tissues from the apoptotic effects of chemotherapeutic agents and/or ionizing radiation. Compounds of the invention act as agonists of the LPA 2 receptor. Compounds of the invention comprise non-lipid benzoic acid derivatives.

  本发明揭示了一种有效抑制细胞凋亡并保护细胞和组织免受化疗药物和/或电离辐射凋亡影响的化合物。本发明的化合物作为LPA2受体的激动剂。本发明的化合物包括非脂肪苯甲酸衍生物。
• LPA2 RECEPTOR-SPECIFIC BENZOIC ACID DERIVATIVES
  申请人：University of Tennessee Research Foundation

  公开号：US20140206714A1

  公开（公告）日：2014-07-24

  Disclosed are compounds effective for inhibiting cellular apoptosis and for protecting cells and tissues from the apoptotic effects of chemotherapeutic agents and/or ionizing radiation. Compounds of the invention act as agonists of the LPA 2 receptor. Compounds of the invention comprise non-lipid benzoic acid derivatives. Further disclosed is a pharmacophore of LPA 2 receptor.

  本发明涉及有效抑制细胞凋亡并保护细胞和组织免受化疗药物和/或电离辐射的凋亡作用的化合物。本发明的化合物作为LPA2受体的激动剂。本发明的化合物包括非脂肪苯甲酸衍生物。此外，本发明还揭示了LPA2受体的药效团。
• US9056835B2
  申请人：——

  公开号：US9056835B2

  公开（公告）日：2015-06-16
• [EN] LPA2 RECEPTOR-SPECIFIC BENZOIC ACID DERIVATIVES<br/>[FR] DÉRIVÉS DE L'ACIDE BENZOÏQUE SPÉCIFIQUES AU RÉCEPTEUR LPA2
  申请人：UNIV TENNESSEE RES FOUNDATION

  公开号：WO2014036038A1

  公开（公告）日：2014-03-06

  Disclosed are compounds effective for inhibiting cellular apoptosis and for protecting cells and tissues from the apoptotic effects of chemotherapeutic agents and/or ionizing radiation. Compounds of the invention act as agonists of the LPA2 receptor. Compounds of the invention comprise non-lipid benzoic acid derivatives.
• [EN] MODULATION OF DENDRITIC CELL FUNCTION BY THE PHOSPHOLIPID MESSENGER LPA<br/>[FR] MODULATION DE LA FONCTION DES CELLULES DENDRITIQUES PAR LE MESSAGER DES PHOSPHOLIPIDES LPA
  申请人：UNIV CORNELL

  公开号：WO2021034414A2

  公开（公告）日：2021-02-25

  Described herein are compositions and methods that include use of PERK inhibitors, inhibitors of enzymes that can synthesize lysophosphatidic acid (LPA), inhibitors of LPA signaling, such as LPA receptor antagonists, deletion/mutation knockout/knockdown) or PERK or LPA receptors, or combinations thereof. Such compositions and methods can increase production of interferon by dendritic cells in subjects suffering from cancer and improve the survival of those subjects.