1,3,3-trimethylspiropiperidine-2,3'-[3H]-naphth-[2,1-b]-1,4-oxazine | 111204-13-8

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并恶嗪类
• 英文名称: 1,3,3-trimethylspiropiperidine-2,3'-[3H]-naphth-[2,1-b]-1,4-oxazine
• 英文别名: 1',3',3'-Trimethylspiro[naphtho[2,1-B][1,4]oxazine-3,2'-piperidine]；1',3',3'-trimethylspiro[benzo[f][1,4]benzoxazine-3,2'-piperidine]
• CAS: 111204-13-8
• 化学式: C₁₉H₂₂N₂O
• 分子量: 294.396
• InChiKey: GTQAWIAIAGTGEA-UHFFFAOYSA-N

物化性质

• 熔点：
  104-105 °C
• 沸点：
  453.7±45.0 °C(Predicted)
• 密度：
  1.15±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  4.1
• 重原子数：
  22
• 可旋转键数：
  0
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.42
• 拓扑面积：
  24.8
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  1-氨基-2-萘酚 、 1,3,3-Trimethyl-2-methylene-piperidine 在 碳酸氢钠 、 magnesium sulfate 作用下， 以 二甲基亚砜 、 甲苯 为溶剂， 反应 4.0h， 以28%的产率得到1,3,3-trimethylspiropiperidine-2,3'-[3H]-naphth-[2,1-b]-1,4-oxazine
  参考文献：
  名称：

  Synthesis of photochromic spirooxazines from 1-amino-2-naphthols

  摘要：

  A synthetic access to photochromic spirooxazines is developed through the condensation of methylene-substituted azaheterocycles on 1-amino-2-naphthols in presence of an oxidizing agent. Compared to usual preparation of this kind of compounds (via 1-nitroso-2-naphthols), yields are generally good and approaches to Further spiroheterocyclic oxazines are possible. (C) 1997 Elsevier Science Ltd.

  DOI：

  10.1016/s0040-4020(97)00640-6

文献信息

• A New Photochromic Spiro[3<i>H</i>-1,4-oxazine]
  作者：Susumu Kawauchi、Haruo Yoshida、Naoko Yamashina、Manabu Ohira、Shigeru Saeda、Masahiro Irie

  DOI：10.1246/bcsj.63.267

  日期：1990.1

  A new photochromic spiro[3H-1,4-oxazine] 4 is described. The absorption spectra of 4 have been examined and compared with those of spiro[indoline-naphthoxazine] 1. The colored form of 4 has the absorption maximum shorter than that of 1. Compound 4 showed excellent light fatigue-resistant property.

  本文描述了一种新的光致变色螺[3H-1,4-恶嗪] 4。研究了 4 的吸收光谱，并与螺[吲哚啉-萘恶嗪] 1 的吸收光谱进行了比较。4 的有色形式比 1 的吸收最大值短。
• Spiropiperidinenaphthoxazine compound
  申请人：Showa Denko Kabushiki Kaisha

  公开号：US04772700A1

  公开（公告）日：1988-09-20

  A spiropiperidine-naphthoxazine compound represented by the following general formula (I) is valuable as a photochromic compound: ##STR1## wherein (a) R.sub.1 represents a C1-C18 alkyl group, C7-C15 aralkyl group which may be substituted, a C1-C10 alkenyl group or a C6-C15 aryl group which may be substituted, (b) R.sub.2 through R.sub.9 represent a group R.sub.1 defined above, a hydrogen atom, or a C5-C10 alicyclic ring or a norbonyl or adamantyl group, which is bonded between groups present on one skeleton carbon atom or between groups on adjacent skeleton carbon atoms (at the ortho-position), (c) R.sub. 10 represents a C1-C18 alkyl group, a C7-C15 aralkyl group which may be substituted or a C1-C10 alkenyl group, and (d) R.sub.11 through R.sub.16 represent a hydrogen atom, a C1-C9 alkyl group, a C1-C5 alkoxyl group, a halogen atom, a nitro group or a cyano group.

  一种由以下一般式（I）表示的螺环哌啶-萘氧噁啉化合物作为光变化化合物具有很大价值：##STR1## 其中（a）R.sub.1代表C1-C18烷基，C7-C15芳基烷基，可能被取代，C1-C10烯基或C6-C15芳基，可能被取代，（b）R.sub.2到R.sub.9代表上述定义的R.sub.1基团，氢原子，或者一个C5-C10脂环或一个环庚烷基或金刚烷基基团，其在一个骨架碳原子上或在相邻骨架碳原子之间（在邻位）连接，（c）R.sub.10代表C1-C18烷基，C7-C15芳基烷基，可能被取代，或C1-C10烯基，以及（d）R.sub.11到R.sub.16代表氢原子，C1-C9烷基，C1-C5烷氧基，卤素原子，硝基基团或氰基团。
• Peptide-based multimeric targeted contrast agents
  申请人：Zhang Zhaoda

  公开号：US20060039861A1

  公开（公告）日：2006-02-23

  Peptides and peptide-targeted multimeric contrast agents are described, as well as methods of making and using the contrast agents.

  本文描述了肽和肽靶向多聚对比剂，以及制备和使用对比剂的方法。
• SPIROPIPERIDINENAPHTOXAZINE COMPOUNDS
  申请人：SHOWA DENKO KABUSHIKI KAISHA

  公开号：EP0250599A1

  公开（公告）日：1988-01-07

  Spiropiperidinenaphtoxazine compounds represented by general formula (I) are useful as photochromic compounds, wherein (a) R1 represents a C1-18alkyl group, an optionally substituted C7-15 aralkyl group, a C1-10 alkenyl group, or an optionally substituted C6-15 aryl group; (b) R2 to R9 are the same as defined for R1, or each represents a hydrogen atom or is bound to each other to form a C5-10 alicyclic ring, norbornyl or adamantyl on the same skeletal carbon atom or between adjacent (o-position) skeletal carbon atoms; (c) Rio represents a hydrogen atom, a C1-18 alkyl group, a C7-15 aralkyl group which may be optionally substituted, or a C1-10 alkenyl group; and (d) R11 to R16 each represents a hydrogen atom, a C1-9 alkyl, C1-5 alkoxy, halogen, nitro or cyano group.

  通式(I)代表的哌啶基萘并噁嗪化合物可用作光致变色化合物，其中 (a) R1 代表 C1-18 烷基、任选取代的 C7-15 芳烷基、C1-10 烯基或任选取代的 C6-15 芳基；(b) R2 至 R9 与 R1 的定义相同，或各自代表一个氢原子，或相互结合在同一骨架碳原子上或相邻（邻位）骨架碳原子之间形成一个 C5-10 脂环、降冰片烷基或金刚烷基；(c) Rio 代表氢原子、C1-18 烷基、可任选取代的 C7-15 芳烷基或 C1-10 烯基；以及 (d) R11 至 R16 各自代表氢原子、C1-9 烷基、C1-5 烷氧基、卤素、硝基或氰基。
• MATSUOKA, SINGO;TANAKA, TAKASI;KITA, YASUTSUGU
  作者：MATSUOKA, SINGO、TANAKA, TAKASI、KITA, YASUTSUGU

  DOI：——

  日期：——