4-chloro-3-fluoro-2-methylbenzoic acid | 157652-29-4

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 4-chloro-3-fluoro-2-methylbenzoic acid
• CAS: 157652-29-4
• 化学式: C₈H₆ClFO₂
• 分子量: 188.586
• InChiKey: UBVRMICSRMVWNX-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.5
• 重原子数：
  12
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.12
• 拓扑面积：
  37.3
• 氢给体数：
  1
• 氢受体数：
  3

文献信息

• BENZOIC ACID DERIVATIVE MDM2 INHIBITOR FOR THE TREATMENT OF CANCER
  申请人：AMGEN INC.

  公开号：US20140243372A1

  公开（公告）日：2014-08-28

  The present invention provides a MDM2 inhibitor compound, or a pharmaceutically acceptable salt thereof, which compound is useful as a therapeutic agent, particularly for the treatment of cancers. The present invention also relates to pharmaceutical compositions that contains the MDM2 inhibitor.

  本发明提供了一种MDM2抑制剂化合物，或其药用可接受的盐，该化合物可作为治疗剂，特别是用于癌症治疗。本发明还涉及含有MDM2抑制剂的药物组合物。
• 3-cyclopropyl-4-(3-amino-2-methylbenzoyl)pyrazoles and their use as herbicides
  申请人：Schmitt Monika

  公开号：US20060128568A1

  公开（公告）日：2006-06-15

  What is described are 3-cyclopropyl-4-(3-amino-2-methylbenzoyl)pyrazoles of the formula (I) and their use as herbicides. In this formula (I), R 1 , R 2 , R 3 , R 4 and R 5 are various radicals.

  所描述的是式(I)的3-环丙基-4-(3-氨基-2-甲基苯甲酰)吡唑醇，以及它们作为除草剂的用途。在这个式(I)中，R1、R2、R3、R4和R5是各种基团。
• 4-Benzoyl isoxazoles and their use as herbicides
  申请人：RHONE POULENC AGRICULTURE LTD.

  公开号：EP0609798A1

  公开（公告）日：1994-08-10

  The invention relates to 4-benzoylisoxazole derivatives of formula (I): wherein: R represents the hydrogen atom or a group -CO₂R⁴; R¹ represents alkyl, haloalkyl or optionally substituted cycloalkyl; R² represents halogen, optionally halogenated alkyl, alkenyl or alkynyl, alkyl substituted by one or more groups -OR⁵; or a group selected from nitro, cyano, -CO₂R⁵, -S(O)pR⁶, -O(CH₂)mOR⁵, -COR⁵, -NR⁶¹R⁶², -N(R⁸)SO₂R⁷, -OR⁵, -OSO₂R⁷ and -(CR⁹R¹⁰)t-S(O)qR⁷; R³ represents -S(O)qR⁷; X represents -(CR⁹R¹⁰)t-; n represents zero or an integer from one to four; R⁴ represents alkyl or haloalkyl R⁵ represents optionally halogenated alkyl, alkenyl or alkynyl; R⁶, R⁶¹ and R⁶², which may be the same or different, each represents alkyl, haloalkyl or optionally substituted phenyl; R⁷ represents optionally halogenated alkyl, alkenyl or alkynyl, or optionally subtituted phenyl or benzyl; R⁸ represents hydrogen or optionally halogenated alkyl, alkenyl or alkynyl; R⁹ and R¹⁰, which may be the same or different, each represents hydrogen, alkyl, haloalkyl or optionally substituted phenyl p represents zero, one or two; q represents zero, one or two; m represents 1, 2 or 3; t represents an integer from one to four;    or an agriculturally acceptable salt thereof; and to their use as herbicides.

  本发明涉及式（I）的 4-苯甲酰异噁唑衍生物： 其中 R 代表氢原子或基团 -CO₂R⁴ ； R¹ 代表烷基、卤代烷基或任选取代的环烷基； R² 代表卤素、任选卤代的烷基、烯基或炔基、被一个或多个基团 -OR⁵ 取代的烷基；或选自硝基、氰基、-CO₂R⁵、-S(O)pR⁶、-O(CH₂)mOR⁵、-COR⁵、-NR⁶¹R⁶²、-N(R⁸)SO₂R⁷、-OR⁵、-OSO₂R⁷和-(CR⁹R¹⁰)t-S(O)qR⁷的基团； R³ 代表-S(O)qR⁷； X 代表-(CR⁹R¹⁰)t-； n 代表零或一至四的整数； R⁴ 代表烷基或卤代烷基 R⁵ 代表任选卤代烷基、烯基或炔基； R⁶、R⁶¹ 和 R⁶² 可以相同或不同，各自代表烷基、卤代烷基或任选取代的苯基； R⁷ 代表任选卤代烷基、烯基或炔基，或任选取代的苯基或苄基； R⁸ 代表氢或任选卤代的烷基、烯基或炔基； R⁹ 和 R¹⁰ 可以相同或不同，各自代表氢、烷基、卤代烷基或任选取代的苯基 p 代表零、一个或两个 q 代表零、一个或两个 m 代表 1、2 或 3； t 代表一至四的整数； 或其农业上可接受的盐；以及它们作为除草剂的用途。
• Combination therapy including an MDM2 inhibitor and one or more additional pharmaceutically active agents for the treatment of cancers
  申请人：AMGEN INC.

  公开号：US10881648B2

  公开（公告）日：2021-01-05

  The present invention provides combination therapy that includes an MDM2 inhibitor and one or more additional pharmaceutically active agents, particularly for the treatment of cancers. The invention also relates to pharmaceutical compositions that contain an MDM2 inhibitor and one or more additional pharmaceutically active agents for the treatment of cancers.

  本发明提供了包括MDM2抑制剂和一种或多种额外的药学活性剂的组合疗法，特别是用于治疗癌症的组合疗法。 本发明还涉及用于治疗癌症的包含 MDM2 抑制剂和一种或多种额外药学活性剂的药物组合物。
• 4-BENZOYLISOXAZOLE DERIVATIVES AND THEIR USE AS HERBICIDES
  申请人：RHONE POULENC AGRICULTURE LTD.

  公开号：EP0759911A1

  公开（公告）日：1997-03-05