1-[2-[2-[2-[2-(2-hydroxyethoxy)ethoxy]ethoxy]ethoxy]ethoxy]anthraquinone | 701250-18-2

• 分子结构分类: 有机化合物 - 苯类化合物 - 蒽
• 英文名称: 1-[2-[2-[2-[2-(2-hydroxyethoxy)ethoxy]ethoxy]ethoxy]ethoxy]anthraquinone
• 英文别名: 1-[2-[2-[2-[2-(2-hydroxyethoxy)ethoxy]ethoxy]ethoxy]ethoxy]-9,10-anthraquinone；1-[2-[2-[2-[2-(2-Hydroxyethoxy)ethoxy]ethoxy]ethoxy]ethoxy]anthracene-9,10-dione
• CAS: 701250-18-2
• 化学式: C₂₄H₂₈O₈
• 分子量: 444.482
• InChiKey: YXOFGRIABXLZAC-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2
• 重原子数：
  32
• 可旋转键数：
  15
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.42
• 拓扑面积：
  101
• 氢给体数：
  1
• 氢受体数：
  8

反应信息

• 作为产物：
  描述：

  羟丙基淀粉磷酸酯 、 1-氯蒽醌 在 potassium carbonate 作用下， 反应 3.0h， 生成 1-[2-[2-[2-[2-(2-hydroxyethoxy)ethoxy]ethoxy]ethoxy]ethoxy]anthraquinone
  参考文献：
  名称：

  Synthesis of Water-Soluble 9,10-Anthraquinone Analogues with Potent Cyanobactericidal Activity toward the Musty-Odor Cyanobacterium Oscillatoria perornata

  摘要：

  A series of water-soluble 9,10-anthraquinone analogues were prepared and evaluated for their selective toxicity toward Oscillatoria perornata, which grows in catfish production ponds and causes,"musty" off-flavor in channel catfish (Ictalurus punctatus). Water-soluble mono- and dicationic salts were prepared by conjugating various small amines directly or through a methylene or ethylene bridge to the 9,10-anthraquinone nucleus. One of the dicationicsalts, 2-[N-(1'-methyl-4'-N,N-diethylaminobutyl)aminometyl]anthraquinone diphosphate, exhibited very high water solubility and potent selective toxicity toward O. perornata. However, the tendency of this compound to potentially bind to suspended sediments may be the reason for its limitations in controlling O. perornata in catfish production ponds. The monocationic salt, 2-[N-(1'-methylethyl)]aminomethyl]anthraquinone monophosphate, showed good solubility and high selective toxicity toward O. perornata. Neutral water-soluble analogues prepared by conjugating terta- or pentaethylene glycol directly or by a methylene bridge to the 9,10-anthraquinone nucleus had less activity than the parent compound.

  DOI：

  10.1021/jf072836s

文献信息

• Novel selective algaecides for control of cyanochloronta
  申请人：——

  公开号：US20040116536A1

  公开（公告）日：2004-06-17

  We have now discovered that certain 9,10-anthraquinone derivatives we developed possess potent activity against O. perornata while possessing a sufficiently high level of solubility in water to make their activity against O. perornata viable. These compounds possess a high level of activity against O. perornata yet are relatively non-toxic to green algae and fishes. The compounds also possess a relatively short half-life. The compounds represent a new means to providing compounds possessing a high degree of selective activity against blue-green algae while being physiologically tolerated by catfish and green algae. The compounds provide a means for controlling blue-green algae in managed bodies of water that are destined for public use or consumption.

  我们现在发现，我们开发的某些9,10-蒽醌衍生物具有对O. perornata的强效活性，同时具有足够高的水溶性，使它们对O. perornata的活性变得可行。这些化合物具有对O. perornata的高活性，但相对于绿藻和鱼类来说毒性较小。这些化合物也具有相对较短的半衰期。这些化合物代表了一种新的手段，提供了一种高度选择性对抗蓝藻的化合物，同时被鲶鱼和绿藻生理耐受。这些化合物提供了一种控制管理水体中蓝藻的手段，这些水体将用于公共使用或消费。
• US6949250B2
  申请人：——

  公开号：US6949250B2

  公开（公告）日：2005-09-27
• [EN] NOVEL SELECTIVE ALGAECIDES FOR CONTROL OF CYANOCHLORONTA<br/>[FR] NOUVEAUX ALGICIDES SELECTIFS DESTINES A LA LUTTE CONTRE LA CYANOCHLORONTA
  申请人：US AGRICULTURE

  公开号：WO2004060061A1

  公开（公告）日：2004-07-22

  Certain newly developed 9, 10-anthraquinone derivatives possess potent activity against O. perornata while possessing a sufficiently high level of solubility in water to make their activity against O. perornata viable. These compounds possess a high level of activity against O. perornata yet are relatively non-toxic to green algae and fishes. The compounds also possess a relatively short half-life. The compounds represent a new means to providing compounds possessing a high degree of selective activity against blue-green algae while being physiologically tolerated by catfish and green algae. The compounds provide a means for controlling blue-green algae in managed bodies of water that are destined for public use or consumption.
• Synthesis of Water-Soluble 9,10-Anthraquinone Analogues with Potent Cyanobactericidal Activity toward the Musty-Odor Cyanobacterium Oscillatoria perornata
  作者：N. P. Dhammika Nanayakkara、Kevin K. Schrader

  DOI：10.1021/jf072836s

  日期：2008.2

  A series of water-soluble 9,10-anthraquinone analogues were prepared and evaluated for their selective toxicity toward Oscillatoria perornata, which grows in catfish production ponds and causes,"musty" off-flavor in channel catfish (Ictalurus punctatus). Water-soluble mono- and dicationic salts were prepared by conjugating various small amines directly or through a methylene or ethylene bridge to the 9,10-anthraquinone nucleus. One of the dicationicsalts, 2-[N-(1'-methyl-4'-N,N-diethylaminobutyl)aminometyl]anthraquinone diphosphate, exhibited very high water solubility and potent selective toxicity toward O. perornata. However, the tendency of this compound to potentially bind to suspended sediments may be the reason for its limitations in controlling O. perornata in catfish production ponds. The monocationic salt, 2-[N-(1'-methylethyl)]aminomethyl]anthraquinone monophosphate, showed good solubility and high selective toxicity toward O. perornata. Neutral water-soluble analogues prepared by conjugating terta- or pentaethylene glycol directly or by a methylene bridge to the 9,10-anthraquinone nucleus had less activity than the parent compound.