3-[(4-Methylsulfonylphenyl)methyl]-7,8,12,13-tetraoxaspiro[5.7]tridecane | 1023309-49-0

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 3-[(4-Methylsulfonylphenyl)methyl]-7,8,12,13-tetraoxaspiro[5.7]tridecane
• CAS: 1023309-49-0
• 化学式: C₁₇H₂₄O₆S
• 分子量: 356.44
• InChiKey: XIUIJBYYOVJZRB-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.8
• 重原子数：
  24
• 可旋转键数：
  3
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.65
• 拓扑面积：
  79.4
• 氢给体数：
  0
• 氢受体数：
  6

反应信息

• 作为产物：
  描述：

  1-((4,4-dihydroperoxycyclohexyl)methyl)-4-(methylsulfonyl)benzene 、 1,3-二碘丙烷 在 silver(l) oxide 作用下， 以 乙酸乙酯 为溶剂， 以32%的产率得到3-[(4-Methylsulfonylphenyl)methyl]-7,8,12,13-tetraoxaspiro[5.7]tridecane
  参考文献：
  名称：

  An efficient route into synthetically challenging bridged achiral 1,2,4,5-tetraoxanes with antimalarial activity

  摘要：

  Here we present an efficient route into synthetically challenging bridged 1,2,4,5-tetraoxanes. The key to the success of this route is the use of H2O2 and catalytic I-2 to form the gem-dihydroperoxide followed by a Ag2O mediated alkylation using 1,3-diiodopropane. Using this methodology a range of bridged tetraoxanes which display good in vitro antimalarial activity were synthesized. (C) 2008 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2008.01.053

文献信息

• An efficient route into synthetically challenging bridged achiral 1,2,4,5-tetraoxanes with antimalarial activity
  作者：Gemma L. Ellis、Richard Amewu、Charlotte Hall、Karen Rimmer、Steven A. Ward、Paul M. O’Neill

  DOI：10.1016/j.bmcl.2008.01.053

  日期：2008.3

  Here we present an efficient route into synthetically challenging bridged 1,2,4,5-tetraoxanes. The key to the success of this route is the use of H2O2 and catalytic I-2 to form the gem-dihydroperoxide followed by a Ag2O mediated alkylation using 1,3-diiodopropane. Using this methodology a range of bridged tetraoxanes which display good in vitro antimalarial activity were synthesized. (C) 2008 Elsevier Ltd. All rights reserved.